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Ethers, epoxides and acetals

1,2-Dimethoxyethane

Also known as Monoglyme, Ethylene glycol dimethyl ether, Glyme

CAS 110-71-4Formula C4H10O2Molar mass 90.12 g/molEC 203-794-9
GHS signal word: Danger. Pictograms: Flammable, Harmful or irritant, Serious health hazard 77 suppliers listed
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1,2-Dimethoxyethane chemical structure, C4H10O2, CAS 110-71-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Water-white liquid
Melting point
-58 °C
Boiling point
82 to 83
Density
Relative density (water = 1): 0.86
Flash point
-2 °C
HS code
290919
Category
Ethers, epoxides and acetals
UN number
UN 2252
Illustrative photo, clear liquid in sealed glass ampoules on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is 1,2-Dimethoxyethane?

Plain description, key identifiers and synonyms

1,2-dimethoxyethane is a diether that is the 1,2-dimethyl ether of ethane-1,2-diol. It has a role as a non-polar solvent. It is functionally related to an ethylene glycol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,2-dimethoxyethane
CAS number
110-71-4 CAS number cross-checked
EC number
203-794-9
Molecular formula
C4H10O2
UNII
GXS24JF5IW
MDL number
MFCD00008502
InChIKey
XTHFKEDIFFGKHM-UHFFFAOYSA-N
InChI
InChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
SMILES (canonical and isomeric)
COCCOC

Synonyms

  • Monoglyme
  • Ethylene glycol dimethyl ether
  • Glyme
  • Dimethyl Cellosolve
  • Dimethoxyethane
  • Egdme
  • 2,5-Dioxahexane
  • Ethane, 1,2-dimethoxy-
  • Glycol dimethyl ether
  • Dimethylcellosolve
  • Hisolve MMM
  • Ethylene dimethyl ether
  • Ansul ether 121
  • DME (glycol ether)
  • Monoethylene glycol dimethyl ether
  • alpha,beta-Dimethoxyethane
  • GDME
  • 1,2-Ethanediol, dimethyl ether
  • Dimethylglycol
  • Dimethyl Glycol
  • 1,2-Dimethoxyethan
  • mono-Glyme
  • 1,2-Ethanediol dimethyl ether
  • Ethylenglycoldimethylether
  • Ethylenglykoldimethylether
Show all 37 synonyms
  • 1,2-dimethoxy-ethane
  • 1,2-Dimethylcyclohexane, ethylene glycol dimethyl ether
  • 1,2-dimethoxy ethane
  • Ethane-1,1,2,2-d4, 1,2-dimethoxy-
  • 1, 2-Dimethoxyethane
  • ASTM Method D4815/D5599 1,2-Dimethoxyethane IS
  • dimetoxyethane
  • ethyleneglycol dimethyl ether
  • Dimethoxyethan
  • 1,2dimethoxyethane
  • 1,2 dimethoxyethan
  • 1,2-dimethoxyetane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Water-white liquidexp.
Odour
SHARP ETHEREAL ODORexp.
Melting point
-58 °Cexp.
Boiling point
82 to 83exp.
Density
Relative density (water = 1): 0.86exp.
Flash point
-2 °Cexp.
Autoignition temperature
202 °Cexp.
Solubility
MISCIBLE WITH WATER, ALCOHOL, SOL IN HYDROCARBON SOLVENTSexp.
Vapour pressure
48 MM HG @ 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
90.12 g/molcalc.
Exact mass
90.0681 Dacalc.
LogP (octanol/water)
0.28calc.
Topological polar surface area
18.46 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
6calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
220NFPA 704 rating

Hazard statements

  • H225Highly flammable liquid and vapour.
  • H332Harmful if inhaled.
  • H360FDMay damage fertility. May damage the unborn child.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2252
Transport hazard class
3
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

1,2-Dimethoxyethane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 77 suppliers
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Where suppliers are based

77 suppliers in 12 countries

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1,2-Dimethoxyethane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Solvent to facilitate formation of alkali metal-hydrocarbon adducts, in reformatsky reaction with methyl gamma-bromocrotonate.

Process solvent/solubilizer.

Industrial uses: Solvent, Energy Releasers (explosives, motive propellant), Propellants, non-motive (blowing agents), Ion exchange agent.

Consumer uses: Propellants, non-motive (blowing agents), Solvent, Energy Releasers (explosives, motive propellant).

Roles

  • non-polar solvent
  • solvent

Functional uses

  • Plasticizer
  • Wetting agent (non-aqueous)

How it is made

From ethylene glycol monomethyl ether, methyl sulfate and metallic sodium, from chloromethyl methyl ether in the presence of sodium by wurtz reactions.

From ethylene glycol monomethyl ether, methyl chloride and sodium.

Ethylene glycol monomethyl ether + dimethyl sulphate (ether formation)

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 603-031-00-3

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Ethylene glycol dimethyl ether (EGDME), Ref no: 1142, Annex ref: II/1142

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Significant new use rule

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 1,2-Dimethoxyethane is traded under.

HS 2909.19Indicative HS code

Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…

World exports in 2024
$10.2B
−8.7% vs 2023, imports $10.4B
2019 to 2024
Top exporters
  1. United States32.0%
  2. China22.3%
  3. Saudi Arabia12.9%
Top importers
  1. Singapore16.5%
  2. Mexico14.8%
  3. Japan14.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 1,2-Dimethoxyethane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 1,2-Dimethoxyethane, based on the data on this page

What is 1,2-Dimethoxyethane?

1,2-dimethoxyethane is a diether that is the 1,2-dimethyl ether of ethane-1,2-diol. It has a role as a non-polar solvent. It is functionally related to an ethylene glycol.

What is the CAS number of 1,2-Dimethoxyethane?

The CAS registry number of 1,2-Dimethoxyethane is 110-71-4.

What is the molecular formula and weight of 1,2-Dimethoxyethane?

The molecular formula of 1,2-Dimethoxyethane is C4H10O2 and its molar mass is 90.12 g/mol.

What is 1,2-Dimethoxyethane used for?

Solvent to facilitate formation of alkali metal-hydrocarbon adducts, in reformatsky reaction with methyl gamma-bromocrotonate. Process solvent/solubilizer. Industrial uses: Solvent, Energy Releasers (explosives, motive propellant), Propellants, non-motive (blowing agents), Ion exchange agent.

Is 1,2-Dimethoxyethane hazardous?

1,2-Dimethoxyethane carries the GHS signal word "Danger". Main hazards: highly flammable liquid and vapour, harmful if inhaled, may damage fertility. may damage the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 1,2-Dimethoxyethane?

1,2-Dimethoxyethane is usually classified under HS code 290919 (Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 1,2-Dimethoxyethane?

CompoundList lists 77 suppliers of 1,2-Dimethoxyethane in China, United States, India, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 1,2-Dimethoxyethane in India?

12 suppliers in India list 1,2-Dimethoxyethane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 1,2-Dimethoxyethane?

Suppliers quote 1,2-Dimethoxyethane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 1,2-Dimethoxyethane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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