CompoundList
Sign in
Alcohol and glycol solvents

1,4-Butanediol

Also known as Butane-1,4-diol, Tetramethylene glycol, 1,4-Butylene glycol

CAS 110-63-4Formula C4H10O2Molar mass 90.12 g/molEC 203-786-5
GHS signal word: Warning. Pictograms: Harmful or irritant Controlled, licensed buyers only
Request as a licensed buyer Safety data
1,4-Butanediol chemical structure, C4H10O2, CAS 110-63-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless, oily liquid
Melting point
20.4 °C
Boiling point
229.5 °C
Density
1.0171 g/cm³ at 20 °C
Flash point
134 °C
HS code
290539
Category
Alcohol and glycol solvents

What is 1,4-Butanediol?

Plain description, key identifiers and synonyms

Butane-1,4-diol is a butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16C) with a high boiling point (230C), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF). It has a role as a protic solvent, a prodrug and a neurotoxin. It is a glycol and a butanediol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
butane-1,4-diol
CAS number
110-63-4 CAS number cross-checkedOther or deprecated CAS: 28324-25-6
EC numbers
203-786-5, 615-930-8
Molecular formula
C4H10O2
UNII
7XOO2LE6G3
MDL number
MFCD00002968
INCI name
1,4-BUTANEDIOL
InChIKey
WERYXYBDKMZEQL-UHFFFAOYSA-N
InChI
InChI=1S/C4H10O2/c5-3-1-2-4-6/h5-6H,1-4H2
SMILES (canonical and isomeric)
C(CCO)CO

Synonyms

  • Butane-1,4-diol
  • Tetramethylene glycol
  • 1,4-Butylene glycol
  • 1,4-Dihydroxybutane
  • 1,4-Tetramethylene glycol
  • Sucol B
  • Tetramethylene 1,4-diol
  • DIOL 14B
  • 1,4-BD
  • Agrisynth B1D
  • HO(CH2)4OH
  • 1,4-Dihdyroxybutane
  • HOCH2CH2CH2CH2OH
  • 1,4-butane-d8-diol
  • BDO
  • Polifurit
  • Teracol
  • Terathane
  • 4-hydroxybutanol
  • 1,4butanediol
  • 1.4-butanediol
  • Dabco BDO
  • 1,4-butandiol
  • 1,4-butane diol
  • 1,4-butane-diol
Show all 38 synonyms
  • butane 1,4-diol
  • butane diol-1,4
  • butane-1-4-diol
  • Teracol 30
  • 1,4- butandiol
  • Butan-1.4-diol
  • Terathane 2900
  • Teracol 650
  • 1.4 - butanediol
  • 1,4 butylene glycol
  • Hiprene MC 532
  • Teracol 1000
  • Teracol 2000

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless, oily liquidexp.
Odour
Almost odorlessexp.
Melting point
20.4 °Cexp.
Boiling point
229.5 °Cexp.
Density
1.0171 g/cm³ at 20 °Cexp.
Flash point
134 °Cexp.
Autoignition temperature
350 °Cexp.
Solubility
In water, 1.0 × 10⁺⁶ mg/L at 20 °C /miscible/exp.
Vapour pressure
0.0105 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
90.12 g/molcalc.
Exact mass
90.0681 Dacalc.
LogP (octanol/water)
-0.25calc.
Topological polar surface area
40.46 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
6calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
110NFPA 704 rating

Hazard statements

  • H302Harmful if swallowed.
  • H336May cause drowsiness or dizziness.
Precautionary statements (11)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

1,4-Butanediol suppliers

Controlled substance, listings of documented suppliers only, in the documented ranking

Drug precursor

1,4-Butanediol is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Licensed buyers only, every enquiry is reviewed by our compliance team.

Reference: INCB special surveillance list

Our policy on controlled substances
No documented supplier lists it yet

Licensed buyers can post a request for 1,4-Butanediol with their licence. Our compliance team reviews it before suppliers see it.

Request as a licensed buyer

1,4-Butanediol price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

1,4-Butanediol is a versatile intermediate for the chemical industry. The most important area of application is the production of polyurethanes and poly(butylene terephthalate). Among the polyurethanes produced from 1,4-butanediol, cellular and compact elastomers are of prime importance.

Industrial solvent, intermediate in organic synthesis, polymer feedstock.

Humectant, intermediate for plasticizers, pharmaceuticals, cross-linking agent in polyurethane elastomers, manufacture of tetrahydrofuran, terephthalate plastics.

Industrial uses: Intermediate, Hardener, Surface modifier, Plasticizer, Monomers, Wrinkle resisting agent, Solvent.

Consumer uses: Hardener, Intermediate.

Cosmetic ingredient, INCI name 1,4-BUTANEDIOL(solvent)

Roles

  • Bronsted acid
  • acid
  • aetiopathogenetic role
  • donor
  • neurotoxin
  • pharmaceutical
  • poison
  • polar solvent
  • pro-agent
  • prodrug
  • protic solvent
  • solvent

Functional uses

  • Binder
  • Plasticizer
  • Processing aids not otherwise specified
  • Solvent

Cosmetic functions

  • Solvent

How it is made

From acetylene and formaldehyde by high-pressure synthesis

1,4-Butanediol is made on a large industrial scale by continuous hydrogenation of the 2-butyne-1,4-diol over modified nickel catalysts. The one-stage flow process is carried out at 80 - 160 °C and 300 bar. An aqueous solution of 2-butyne-1,4-diol (30 - 50%), together with carbon monoxide-free hydrogen and recycled reaction mixture, which acts as medium for dissipation of heat, is lead over a reduced nickel - copper - manganese catalysts on silica gel strands.

Read more

The initial temperature in the reactor is 80 °C, the temperature must not exceed 170 °C. In order to obtain a better distribution of the liquid, hydrogen is also circulated. The raw product contains methanol, propanol, and butanol as byproducts as well as traces of 2-methyl-1,4-butanediol, hydroxybutyraldehyde, acetals, and triols. The reactor effluent is worked up to pure 1,4-butanediol by fractional distillation.

Mitsubishi uses a three-step process: (1) the catalytic reaction of butadiene and acetic acid yields 1,4-diacetoxy-2-butene, (2) subsequent hydrogenation gives 1,4-diacetoxybutane, and (3) hydrolysis leads to 1,4-butanediol.

Regulatory status

Inventories, regulations and trade controls that list this substance

Drug precursor

1,4-Butanediol is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Licensed buyers only, every enquiry is reviewed by our compliance team.

Reference: INCB special surveillance list

Our policy on controlled substances

Health and food

  • EU cosmetic ingredient inventory

Controls

  • Drug precursor (UN 1988 Convention)

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 1,4-Butanediol is traded under.

HS 2905.39Indicative HS code

Diols, other

World exports in 2024
$1.92B
−3.5% vs 2023, imports $2B
2019 to 2024
Top exporters
  1. China22.3%
  2. United States17.9%
  3. Germany16.1%
Top importers
  1. Germany12.0%
  2. China11.3%
  3. South Korea10.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 1,4-Butanediol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 1,4-Butanediol, based on the data on this page

What is 1,4-Butanediol?

Butane-1,4-diol is a butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p.

What is the CAS number of 1,4-Butanediol?

The CAS registry number of 1,4-Butanediol is 110-63-4. Other or deprecated CAS numbers: 28324-25-6.

What is the molecular formula and weight of 1,4-Butanediol?

The molecular formula of 1,4-Butanediol is C4H10O2 and its molar mass is 90.12 g/mol.

What is 1,4-Butanediol used for?

1,4-Butanediol is a versatile intermediate for the chemical industry. The most important area of application is the production of polyurethanes and poly(butylene terephthalate). Among the polyurethanes produced from 1,4-butanediol, cellular and compact elastomers are of prime importance.

Is 1,4-Butanediol hazardous?

1,4-Butanediol carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause drowsiness or dizziness. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 1,4-Butanediol?

1,4-Butanediol is usually classified under HS code 290539 (Diols, other). This is indicative, confirm it with your customs broker before shipping.

Can I buy 1,4-Butanediol on CompoundList?

1,4-Butanediol is a controlled substance. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed by our compliance team before suppliers see it.

Guides for buyers

Practical guides that help when you source, ship or handle 1,4-Butanediol

Request as a licensed buyer

Upload your licence with the request. Our compliance team reviews it before the documented suppliers see it.
Request as a licensed buyer
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of 1,4-Butanediol with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/1-4-butanediol-110-63-4" title="1,4-Butanediol structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Alcohol and glycol solvents or HS code 290539

Price on request
Free quotes, contact stays private
Licensed request