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Ethers, epoxides and acetals

Triglyme

Also known as 2,5,8,11-Tetraoxadodecane, Triethylene glycol dimethyl ether, 1,2-Bis(2-methoxyethoxy)ethane

CAS 112-49-2Formula C8H18O4Molar mass 178.23 g/molEC 203-977-3
GHS signal word: Danger. Pictograms: Serious health hazard 10 suppliers listed
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Triglyme chemical structure, C8H18O4, CAS 112-49-2
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Liquid
Melting point
-45 °C
Boiling point
216 °C
Density
Relative density (water = 1): 0.99
Flash point
111 °C
HS code
290919
Category
Ethers, epoxides and acetals
Illustrative photo, closed blue jerry cans in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Triglyme?

Plain description, key identifiers and synonyms

Triglyme is a polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms. It has a role as a solvent.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane
CAS number
112-49-2 CAS number cross-checked
EC number
203-977-3
Molecular formula
C8H18O4
UNII
32YXG88KK0
MDL number
MFCD00008504
InChIKey
YFNKIDBQEZZDLK-UHFFFAOYSA-N
InChI
InChI=1S/C8H18O4/c1-9-3-5-11-7-8-12-6-4-10-2/h3-8H2,1-2H3
SMILES (canonical and isomeric)
COCCOCCOCCOC

Synonyms

  • 2,5,8,11-Tetraoxadodecane
  • Triethylene glycol dimethyl ether
  • 1,2-Bis(2-methoxyethoxy)ethane
  • Glyme 4
  • Ansul ether 161
  • Glyme-3
  • 1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane
  • Tegdime
  • Tegdme
  • Dimethyl ether of triethylene glycol
  • Ethane, 1,2-bis(2-methoxyethoxy)-
  • 1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)ethane
  • Methyltriglyme
  • Hisolve mtm
  • 1-Methoxy-2-[2-(2-methoxy-ethoxy]-ethane
  • triethylene glycol dimethylether
  • triethyleneglycol dimethyl ether
  • Triethylene glycol dimethyl ether (stabilized with BHT)
  • Glyme-4
  • Glycol, triethylene-, dimethyl ether
  • Dimethyltriglycol
  • 2,8,11-Tetraoxadodecane
  • 1,2-Bis(methoxyethoxy)ethane
  • Ethane,2-bis(2-methoxyethoxy)-
  • (CH3O(CH2)2OCH2)2
Show all 29 synonyms
  • Triethylene glycol dimethyl ether, ReagentPlus(R), 99%
  • Triethylene glycol dimethyl ether 100 microg/mL in Acetonitrile
  • Triethylene glycol dimethyl ether, analytical reference material
  • Triethylene glycol dimethyl ether Solution in Methanol, 1000ug/mL

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Liquidexp.
Melting point
-45 °Cexp.
Boiling point
216 °Cexp.
Density
Relative density (water = 1): 0.99exp.
Flash point
111 °Cexp.
Autoignition temperature
630 °Cexp.
Solubility
Solubility in water: miscibleexp.
Vapour pressure
Vapor pressure, kPa at 20 °C: 0.12exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
178.23 g/molcalc.
Exact mass
178.1205 Dacalc.
LogP (octanol/water)
0.31calc.
Topological polar surface area
36.92 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
9calc.
Heavy atoms
12calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H360DfMay damage the unborn child. Suspected of damaging fertility.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Triglyme suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 10 suppliers
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Where suppliers are based

10 suppliers in 4 countries

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Triglyme price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • solvent

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 603-176-00-2

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: 1,2-Bis(2-methoxyethoxy)ethane, Triethylene glycol dimethyl ether, (TEGDME), triglyme, Ref no: 1147, Annex ref: II/1147

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Significant new use rule

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Triglyme is traded under.

HS 2909.19Indicative HS code

Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…

World exports in 2024
$10.2B
−8.7% vs 2023, imports $10.4B
2019 to 2024
Top exporters
  1. United States32.0%
  2. China22.3%
  3. Saudi Arabia12.9%
Top importers
  1. Singapore16.5%
  2. Mexico14.8%
  3. Japan14.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Triglyme is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Triglyme, based on the data on this page

What is Triglyme?

Triglyme is a polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms. It has a role as a solvent.

What is the CAS number of Triglyme?

The CAS registry number of Triglyme is 112-49-2.

What is the molecular formula and weight of Triglyme?

The molecular formula of Triglyme is C8H18O4 and its molar mass is 178.23 g/mol.

What is Triglyme used for?

Known uses and roles of Triglyme include building blocks in research and laboratory and solvent.

Is Triglyme hazardous?

Triglyme carries the GHS signal word "Danger". Main hazards: may damage the unborn child. suspected of damaging fertility. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Triglyme?

Triglyme is usually classified under HS code 290919 (Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Triglyme?

CompoundList lists 10 suppliers of Triglyme in China, Germany, India and Japan. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Triglyme in India?

1 supplier in India list Triglyme on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Triglyme?

Suppliers quote Triglyme on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Triglyme

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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