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Cosmetic ingredients

Diglyme

Also known as 1-Methoxy-2-(2-methoxyethoxy)ethane, Bis(2-methoxyethyl) ether, Diethylene glycol dimethyl ether

CAS 111-96-6Formula C6H14O3Molar mass 134.18 g/molEC 203-924-4
GHS signal word: Danger. Pictograms: Flammable, Serious health hazard 44 suppliers listed
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Diglyme chemical structure, C6H14O3, CAS 111-96-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid
Melting point
-68 °C
Boiling point
162 °C
Density
Sp gr: 0.9451 at 20 °C/20 °C
Flash point
67 °C
HS code
290919
Category
Cosmetic ingredients
UN number
UN 2252
Illustrative photo, clear liquid in a volumetric flask on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Diglyme?

Plain description, key identifiers and synonyms

Diglyme is a polyether that is the dimethyl ether derivative of diethylene glycol. It has a role as a xenobiotic, a solvent and an environmental contaminant. It is functionally related to a diethylene glycol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-methoxy-2-(2-methoxyethoxy)ethane
CAS number
111-96-6 CAS number cross-checkedOther or deprecated CAS: 248243-66-5
EC number
203-924-4
Molecular formula
C6H14O3
UNII
M4BH3X0MVZ
MDL number
MFCD00008503
INCI name
DIMETHOXYDIGLYCOL
InChIKey
SBZXBUIDTXKZTM-UHFFFAOYSA-N
InChI
InChI=1S/C6H14O3/c1-7-3-5-9-6-4-8-2/h3-6H2,1-2H3
SMILES (canonical and isomeric)
COCCOCCOC

Synonyms

  • 1-Methoxy-2-(2-methoxyethoxy)ethane
  • Bis(2-methoxyethyl) ether
  • Diethylene glycol dimethyl ether
  • 2,5,8-Trioxanonane
  • Dimethyl carbitol
  • Di(2-Methoxyethyl) ether
  • Bis(2-methoxyethyl)ether
  • Glyme 2
  • Dimethoxydiglycol
  • (2-Methoxyethyl) ether
  • Ether, bis(2-methoxyethyl)
  • Methyldiglyme
  • Diglycol methyl ether
  • Diethyl glycol dimethyl ether
  • Ethane, 1,1'-oxybis[2-methoxy-
  • 2-(2-Methoxyethoxy)-1-methoxyethane
  • diethylene glycol dimethylether
  • 1,1'-Oxybis(2-methoxyethane)
  • 2,2'-oxybis(1-methoxyethane)
  • Ethanol, 2,2'-oxybis-, dimethyl ether
  • Ethane, 1,1'-oxybis(2-methoxy-
  • Hisolve mdm
  • 2,2'-oxybis[1-(methyloxy)ethane]
  • 1,1'-oxybis[2-methoxyethane]
  • 2,2'-oxybis(1-(methyloxy)ethane)
Show all 38 synonyms
  • Degdme
  • DGDME
  • 2-Methoxyethyl ether
  • Glyme-2
  • diethyleneglycol dimethyl ether
  • Dimethyldiglycol
  • Diethylene Glycol Dimethyl Ether(Diglyme)
  • Dimethyldigol
  • 2-methoxyethylether
  • diethyleneglycoldimethylether
  • dimethyl digol
  • methyl diglyme
  • Dimethylcarbitol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Odour
Mild odorexp.
Melting point
-68 °Cexp.
Boiling point
162 °Cexp.
Density
Sp gr: 0.9451 at 20 °C/20 °Cexp.
Flash point
67 °Cexp.
Autoignition temperature
190 °Cexp.
Solubility
In water, miscibleexp.
Vapour pressure
Vapor pressure, kPa at 20 °C: 0.33exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
134.18 g/molcalc.
Exact mass
134.0943 Dacalc.
LogP (octanol/water)
0.3calc.
Topological polar surface area
27.69 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
9calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS08: Serious health hazard
Serious health hazard
211NFPA 704 rating

Hazard statements

  • H226Flammable liquid and vapour.
  • H360FDMay damage fertility. May damage the unborn child.
Precautionary statements (14)
  • P203Obtain, read and follow all safety instructions before use.
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P318If exposed or concerned, get medical advice.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2252
Transport hazard class
3
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Diglyme suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 44 suppliers
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Where suppliers are based

44 suppliers in 9 countries

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Diglyme price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Solvent, reaction medium for Grignard and similar syntheses.

Diethylene glycol dimethyl ether is used as a solvent in chemical reactions involving metals and organometallic compounds.

Solubilizer.

Used in production of plastics.

Industrial uses: Solvent, Intermediate, Plasticizer.

Consumer uses: Plasticizer, Monomers.

Cosmetic ingredient, INCI name DIMETHOXYDIGLYCOL(solvent)

Roles

  • environmental contaminant
  • solvent
  • xenobiotic

Functional uses

  • Solvent

Cosmetic functions

  • Solvent

How it is made

Ethylene glycol ethers are produced by reacting ethylene oxide with alcohols in the presence of either acidic or basic catalysts. Temperature, pressure, mole ratios of reactants, and catalysts are chosen to yield the desired product mix.

Diethylene glycol + dimethyl sulfate (ether formation)

Ethylene glycol monoethers are usually produced by reaction of ethylene oxide with the appropriate alcohol. A mixture of homologues is obtained ... The glycol monoethers can be converted to diethers by alkylation with common alkylating agents, such as dimethyl sulfate or alkyl halides ( Williamson synthesis). Glycol dimethyl ethers are formed by treatment of dimethyl ether with ethylene oxide. (Ethers)

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 603-139-00-0

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: bis(2-Methoxyethyl) ether (Dimethoxydiglycol), Ref no: 676, Annex ref: II/676

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Significant new use rule

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diglyme is traded under.

HS 2909.19Indicative HS code

Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…

World exports in 2024
$10.2B
−8.7% vs 2023, imports $10.4B
2019 to 2024
Top exporters
  1. United States32.0%
  2. China22.3%
  3. Saudi Arabia12.9%
Top importers
  1. Singapore16.5%
  2. Mexico14.8%
  3. Japan14.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Diglyme is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diglyme, based on the data on this page

What is Diglyme?

Diglyme is a polyether that is the dimethyl ether derivative of diethylene glycol. It has a role as a xenobiotic, a solvent and an environmental contaminant. It is functionally related to a diethylene glycol.

What is the CAS number of Diglyme?

The CAS registry number of Diglyme is 111-96-6. Other or deprecated CAS numbers: 248243-66-5.

What is the molecular formula and weight of Diglyme?

The molecular formula of Diglyme is C6H14O3 and its molar mass is 134.18 g/mol.

What is Diglyme used for?

Solvent, reaction medium for Grignard and similar syntheses. Diethylene glycol dimethyl ether is used as a solvent in chemical reactions involving metals and organometallic compounds. Solubilizer. Used in production of plastics. Industrial uses: Solvent, Intermediate, Plasticizer. Consumer uses: Plasticizer, Monomers.

Is Diglyme hazardous?

Diglyme carries the GHS signal word "Danger". Main hazards: flammable liquid and vapour, may damage fertility. may damage the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Diglyme?

Diglyme is usually classified under HS code 290919 (Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diglyme?

CompoundList lists 44 suppliers of Diglyme in China, United States, India, Germany and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diglyme in India?

4 suppliers in India list Diglyme on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diglyme?

Suppliers quote Diglyme on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diglyme

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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