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Impurities and reference standards

14-Hydroxycodeine

Also known as Morphinan-6,14-diol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, (4R,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,7,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol, (4R,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,7,7a,13-hexahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-4a,7-diol

CAS 4829-46-3Formula C18H21NO4Molar mass 315.37 g/molEC 689-807-2
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard
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14-Hydroxycodeine chemical structure, C18H21NO4, CAS 4829-46-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
4829-46-3
Formula
C18H21NO4
Molar mass
315.37 g/mol
EC number
689-807-2
HS code
293499
Category
Impurities and reference standards

What is 14-Hydroxycodeine?

Plain description, key identifiers and synonyms

14-hydroxycodeine has been reported in Papaver bracteatum and Streptomyces griseus.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,7,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol
CAS number
4829-46-3 CAS number cross-checked
EC number
689-807-2
Molecular formula
C18H21NO4
UNII
332OI8E5Z4
InChIKey
YPZPXTZKBNWUTF-QMVVXIJUSA-N
InChI
InChI=1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-6,11,13,16,20-21H,7-9H2,1-2H3/t11-,13+,16-,17-,18+/m0/s1
Canonical SMILES
COc1ccc2c3c1OC1C(O)C=CC4(O)C(C2)N(C)CCC314
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H](C=C[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O)O

Synonyms

  • Morphinan-6,14-diol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-
  • (4R,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,7,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol
  • (4R,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,7,7a,13-hexahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-4a,7-diol
  • Codeine Impurity F
  • 14-Hydroxycodene
  • 14beta-hydroxycodeine
  • 14-Hydroxycodeine (1mg/ml in Acetonitrile)
  • 14-Hydroxycodeine (1 mg/ml in Acetonitrile)
  • Codeine monohydrate impurity f
  • Codeine hydrochloride dihydrate impurity f
  • Codeine phosphate hemihydrate impurity f
  • Codeine phosphate sesquihydrate impurity f
  • 3-Methoxy-17-methyl-5alpha-7,8-didehydro-4,5-epoxymorphinan-6alpha,14-diol
  • 4,5alpha-epoxy-3-methoxy-17-methyl-7,8-didehydromorphinan-6alpha,14-diol
  • (5alpha,6.alpha.)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6,14-diol
  • 7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha,14-diol (14-Hydroxycodeine)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
315.37 g/molcalc.
Exact mass
315.1471 Dacalc.
LogP (octanol/water)
0.62calc.
Topological polar surface area
62.16 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
23calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O5

C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O5

5 rings, 18 atoms.

246 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H332Harmful if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary statements (20)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

14-Hydroxycodeine suppliers

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14-Hydroxycodeine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 14-Hydroxycodeine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 14-Hydroxycodeine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 14-Hydroxycodeine, based on the data on this page

What is 14-Hydroxycodeine?

14-hydroxycodeine has been reported in Papaver bracteatum and Streptomyces griseus.

What is the CAS number of 14-Hydroxycodeine?

The CAS registry number of 14-Hydroxycodeine is 4829-46-3.

What is the molecular formula and weight of 14-Hydroxycodeine?

The molecular formula of 14-Hydroxycodeine is C18H21NO4 and its molar mass is 315.37 g/mol.

Is 14-Hydroxycodeine hazardous?

14-Hydroxycodeine carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause an allergic skin reaction, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 14-Hydroxycodeine?

14-Hydroxycodeine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 14-Hydroxycodeine?

Post a free request on CompoundList and suppliers of 14-Hydroxycodeine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of 14-Hydroxycodeine?

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Guides for buyers

Practical guides that help when you source, ship or handle 14-Hydroxycodeine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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