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Impurities and reference standards

Hydroxycodeinone

Also known as 14-Hydroxycodeinone, Codeinone, 14-hydroxy-, 14beta-Hydroxycodeinone

CAS 508-54-3Formula C18H19NO4Molar mass 313.35 g/molEC 208-085-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe)
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Hydroxycodeinone chemical structure, C18H19NO4, CAS 508-54-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
508-54-3
Formula
C18H19NO4
Molar mass
313.35 g/mol
EC number
208-085-8
HS code
293499
Category
Impurities and reference standards

What is Hydroxycodeinone?

Plain description, key identifiers and synonyms

hydroxycodeinone has been reported in Papaver bracteatum.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
CAS number
508-54-3
EC number
208-085-8
Molecular formula
C18H19NO4
UNII
91138F771G
InChIKey
YYCRAERBSFHMPL-XFKAJCMBSA-N
InChI
InChI=1S/C18H19NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-6,13,16,21H,7-9H2,1-2H3/t13-,16+,17+,18-/m1/s1
Canonical SMILES
COc1ccc2c3c1OC1C(=O)C=CC4(O)C(C2)N(C)CCC314
Isomeric SMILES
CN1CC[C@]23[C@@H]4C(=O)C=C[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O

Synonyms

  • 14-Hydroxycodeinone
  • Codeinone, 14-hydroxy-
  • 14beta-Hydroxycodeinone
  • (5alpha)-7,8-Didehydro-4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
  • Morphinan-6-one, 7,8-didehydro-4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5-alpha)-
  • (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinolin-7-one
  • (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
  • 14-hydroxycodeinone /OD/ 7,8-didehydro-4,5 alpha-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
  • 14-Hydroxy Codeinone
  • 7,8-Didehydro-4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one (14-Hydroxycodeinone)
  • Oxycodone Hydrochloride EP Impurity D
  • Oxycodone impurity D CRS
  • Codeine Phosphate Hemihydrate EP Impurity K
  • Codeine monohydrate impurity k
  • Oxycodone hydrochloride impurity d
  • Codeine hydrochloride dihydrate impurity k
  • Codeine phosphate hemihydrate impurity k
  • (5.Alpha.)-7,8-didehydro-4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
  • 14-Hydroxy-3-methoxy-17-methyl-5alpha-7,8-didehydro-4,5-epoxymorphinan-6-one
  • (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,3,4,4a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
  • Morphinan-6-one, 7,8-didehydro-4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5-.alpha.)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
313.35 g/molcalc.
Exact mass
313.1314 Dacalc.
LogP (octanol/water)
0.82calc.
Topological polar surface area
59 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
23calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C3Cc4cccc5c4C2(CCN3)C1O5

O=C1C=CC2C3Cc4cccc5c4C2(CCN3)C1O5

5 rings, 19 atoms.

29 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300 + H310 + H330Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.
  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H330Fatal if inhaled.
Precautionary statements (18)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hydroxycodeinone suppliers

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Hydroxycodeinone price

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hydroxycodeinone is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Hydroxycodeinone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hydroxycodeinone, based on the data on this page

What is Hydroxycodeinone?

hydroxycodeinone has been reported in Papaver bracteatum.

What is the CAS number of Hydroxycodeinone?

The CAS registry number of Hydroxycodeinone is 508-54-3.

What is the molecular formula and weight of Hydroxycodeinone?

The molecular formula of Hydroxycodeinone is C18H19NO4 and its molar mass is 313.35 g/mol.

Is Hydroxycodeinone hazardous?

Hydroxycodeinone carries the GHS signal word "Danger". Main hazards: fatal if swallowed. fatal in contact with skin. fatal if inhaled, fatal if swallowed, fatal in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hydroxycodeinone?

Hydroxycodeinone is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hydroxycodeinone?

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What is the price of Hydroxycodeinone?

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Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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