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Impurities and reference standards

2,5-Dichlorophenol

Also known as Phenol, 2,5-dichloro-, 2,5-DCP, 2,5-dichloro-phenol

CAS 583-78-8Formula C6H4Cl2OMolar mass 163.00 g/molEC 209-520-4
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant, Hazardous to the environment 16 suppliers listed
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2,5-Dichlorophenol chemical structure, C6H4Cl2O, CAS 583-78-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Prisms from benzene and petroleum ether
Melting point
59 °C
Boiling point
211 °C
Density
Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.00
Solubility
In water, 2,000 mg/L at 25 °C
HS code
290819
Category
Impurities and reference standards
UN number
UN 2020
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is 2,5-Dichlorophenol?

Plain description, key identifiers and synonyms

2,5-dichlorophenol is a dichlorophenol with the chloro substituents at positions 2 and 5. It has a role as a human xenobiotic metabolite.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,5-dichlorophenol
CAS number
583-78-8 CAS number cross-checked
EC number
209-520-4
Molecular formula
C6H4Cl2O
UNII
3B11G9AKBA
MDL number
MFCD00002174
InChIKey
RANCECPPZPIPNO-UHFFFAOYSA-N
InChI
InChI=1S/C6H4Cl2O/c7-4-1-2-5(8)6(9)3-4/h1-3,9H
SMILES (canonical and isomeric)
C1=CC(=C(C=C1Cl)O)Cl

Synonyms

  • Phenol, 2,5-dichloro-
  • 2,5-DCP
  • 2,5-dichloro-phenol
  • 3,6-dichlorophenol
  • Phenol, 2,5-dichloro-, 2,5-Dichlorophenol, NSC 6296
  • Ketoconazole Impurity 51
  • 2,5-dichlorophenol-cp std
  • 2,5-Dichlorophenol, 98%
  • 4-06-00-00942 (Beilstein Handbook Reference)
  • Dichlorophenol, 2,5-
  • 2,5-Dichlorophenol (ACD/Name 4.0)
  • 2,5-Dichlorophenol 10 microg/mL in Methanol
  • 2,5-Dichlorophenol 100 microg/mL in Methanol
  • 2,5-Dichlorophenol Solution in Methanol, 100ug/mL
  • 2,5-Dichlorophenol, PESTANAL(R), analytical standard

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Prisms from benzene and petroleum etherexp.
Taste
Taste Threshold in water - 0.5 ug/l.exp.
Melting point
59 °Cexp.
Boiling point
211 °Cexp.
Density
Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.00exp.
Solubility
In water, 2,000 mg/L at 25 °Cexp.
Vapour pressure
0.0562 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
163.00 g/molcalc.
Exact mass
161.9639 Dacalc.
LogP (octanol/water)
2.7calc.
Topological polar surface area
20.23 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H314Causes severe skin burns and eye damage.
  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H319Causes serious eye irritation.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (24)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
  • P302 + P352If on skin: Wash with plenty of water.
  • P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P363Wash contaminated clothing before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2020
Transport hazard class
6.1
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

2,5-Dichlorophenol suppliers

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Where suppliers are based

16 suppliers in 5 countries

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2,5-Dichlorophenol price

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Uses and applications

What the substance is used for, by industry and function

Chemical intermediate for 3,6-dichloro-o-anisic acid, the herbicide dicamba.

Industrial uses: Intermediate.

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • human xenobiotic metabolite
  • mammalian metabolite
  • metabolite
  • xenobiotic metabolite

How it is made

Hydrolysis of 1,2,4-trichlorobenzene in the presence of sodium methylate, diazotization of 2,5-dichloroaniline followed by decomposition of diazonium salt with sulfuric acid

Hydrolysis of chlorobenzenes can be carried out in alkaline aqueous media, with or without the presence of copper salts. It can be done in the vapor phase at 250 - 400 °C on phosphates or on silica at 500 - 550 °C. Hydrolysis is most frequently carried out in the presence of methanolic sodium or potassium at 150 - 200 °C and 1.0 - 3.0 MPa.

Read more

(Mono-, Di-, and Trichlorophenols with Chlorine in a Meta Position)

Sulfonation of chlorobenzenes followed by the desulfonation of chlorobenzenesulfonic acids can be used to produce numerous chlorophenols. The chlorobenzenes are sulfonated by using 15 - 20% oleum at 60 - 80 °C. The subsequent desulfonation is usually carried out by using 15 - 25% aqueous sodium hydroxide solution at 180 - 220 °C and 1.5 - 3.0 MPa. (Mono-, Di-, and Trichlorophenols with Chlorine in a Meta Position)

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Section 4 test rule or order

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 2,5-Dichlorophenol is traded under.

HS 2908.19Indicative HS code

Derivatives containing only halogen substituents and their salts, other

World exports in 2024
$452M
−8.2% vs 2023, imports $435M
2019 to 2024
Top exporters
  1. Jordan * partner reported36.5%
  2. Israel29.6%
  3. China6.5%
Top importers
  1. China58.6%
  2. South Korea10.3%
  3. United States5.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 2,5-Dichlorophenol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 2,5-Dichlorophenol, based on the data on this page

What is 2,5-Dichlorophenol?

2,5-dichlorophenol is a dichlorophenol with the chloro substituents at positions 2 and 5. It has a role as a human xenobiotic metabolite.

What is the CAS number of 2,5-Dichlorophenol?

The CAS registry number of 2,5-Dichlorophenol is 583-78-8.

What is the molecular formula and weight of 2,5-Dichlorophenol?

The molecular formula of 2,5-Dichlorophenol is C6H4Cl2O and its molar mass is 163.00 g/mol.

What is 2,5-Dichlorophenol used for?

Chemical intermediate for 3,6-dichloro-o-anisic acid, the herbicide dicamba. Industrial uses: Intermediate.

Is 2,5-Dichlorophenol hazardous?

2,5-Dichlorophenol carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes severe skin burns and eye damage, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 2,5-Dichlorophenol?

2,5-Dichlorophenol is usually classified under HS code 290819 (Derivatives containing only halogen substituents and their salts, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 2,5-Dichlorophenol?

CompoundList lists 16 suppliers of 2,5-Dichlorophenol in China, United States, Canada, Germany and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 2,5-Dichlorophenol in India?

1 supplier in India list 2,5-Dichlorophenol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 2,5-Dichlorophenol?

Suppliers quote 2,5-Dichlorophenol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 2,5-Dichlorophenol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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