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Steroids and sterols

2-Hydroxyestriol

Also known as 2-Hydroxy-16alpha,17beta-estriol, 2,16 alpha-dihydroxyestradiol /OD/ estra-1,3,5(10)-triene-2,3,16 alpha,17 beta-tetrol, (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-2,3,16,17-tetrol

CAS 1232-80-0Formula C18H24O4Molar mass 304.39 g/molEC 634-142-5
GHS signal word: Warning. Pictograms: Serious health hazard
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2-Hydroxyestriol chemical structure, C18H24O4, CAS 1232-80-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1232-80-0
Formula
C18H24O4
Molar mass
304.39 g/mol
EC number
634-142-5
HS code
290729
Category
Steroids and sterols

What is 2-Hydroxyestriol?

Plain description, key identifiers and synonyms

2-Hydroxyestriol is a chemical substance with the molecular formula C18H24O4 and a molar mass of 304.39 g/mol. Its CAS registry number is 1232-80-0. The IUPAC name is (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-2,3,16,17-tetrol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-2,3,16,17-tetrol
CAS number
1232-80-0 CAS number cross-checked
EC number
634-142-5
Molecular formula
C18H24O4
UNII
XS3NDJ547R
InChIKey
ZUGCDOZAVASBQT-SLVREZFOSA-N
InChI
InChI=1S/C18H24O4/c1-18-5-4-10-11(13(18)8-16(21)17(18)22)3-2-9-6-14(19)15(20)7-12(9)10/h6-7,10-11,13,16-17,19-22H,2-5,8H2,1H3/t10-,11+,13-,16+,17-,18-/m0/s1
Canonical SMILES
CC12CCC3c4cc(O)c(O)cc4CCC3C1CC(O)C2O
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=CC(=C(C=C34)O)O

Synonyms

  • 2-Hydroxy-16alpha,17beta-estriol
  • 2,16 alpha-dihydroxyestradiol /OD/ estra-1,3,5(10)-triene-2,3,16 alpha,17 beta-tetrol
  • (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-2,3,16,17-tetrol
  • (16a,17ss)-Estra-1,3,5(10)-triene-2,3,16,17-tetrol, 2-Hydroxy-16a,17ss-estriol
  • Estra-1(10),2,4-triene-2,3,16alpha,17beta-tetrol
  • Estra-1,3,5(10)-triene-2,3,16alpha,17beta-tetrol
  • Estra-1,3,5(10)-triene-2,3,16,17-tetrol, (16alpha,17beta)-
  • (16alpha,17.beta.)-estra-1,3,5(10)-triene-2,3,16,17-tetrol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
304.39 g/molcalc.
Exact mass
304.1675 Dacalc.
LogP (octanol/water)
2.29calc.
Topological polar surface area
80.92 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
22calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCC1C2CCC2CCCC21

c1ccc2c(c1)CCC1C2CCC2CCCC21

4 rings, 17 atoms.

585 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H351Suspected of causing cancer.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

2-Hydroxyestriol suppliers

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2-Hydroxyestriol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 2-Hydroxyestriol is traded under.

HS 2907.29Indicative HS code

Polyphenols, phenol-alcohols, other

World exports in 2024
$535M
−27.0% vs 2023, imports $565M
2019 to 2024
Top exporters
  1. India * partner reported17.7%
  2. Germany16.5%
  3. Japan15.8%
Top importers
  1. United States13.1%
  2. Japan8.0%
  3. Belgium7.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 2-Hydroxyestriol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 2-Hydroxyestriol, based on the data on this page

What is 2-Hydroxyestriol?

2-Hydroxyestriol is a chemical substance with the molecular formula C18H24O4 and a molar mass of 304.39 g/mol. Its CAS registry number is 1232-80-0. The IUPAC name is (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-2,3,16,17-tetrol.

What is the CAS number of 2-Hydroxyestriol?

The CAS registry number of 2-Hydroxyestriol is 1232-80-0.

What is the molecular formula and weight of 2-Hydroxyestriol?

The molecular formula of 2-Hydroxyestriol is C18H24O4 and its molar mass is 304.39 g/mol.

Is 2-Hydroxyestriol hazardous?

2-Hydroxyestriol carries the GHS signal word "Warning". Main hazards: suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 2-Hydroxyestriol?

2-Hydroxyestriol is usually classified under HS code 290729 (Polyphenols, phenol-alcohols, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 2-Hydroxyestriol?

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What is the price of 2-Hydroxyestriol?

Suppliers quote 2-Hydroxyestriol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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