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Impurities and reference standards

2-Hydroxyestrone

Also known as Catecholestrone, 2,3-Dihydroxyestra-1,3,5(10)-trien-17-one, (8R,9S,13S,14S)-2,3-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

CAS 362-06-1Formula C18H22O3Molar mass 286.37 g/molEC 636-847-3
GHS signal word: Warning. Pictograms: Serious health hazard 1 supplier listed
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2-Hydroxyestrone chemical structure, C18H22O3, CAS 362-06-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
362-06-1
Formula
C18H22O3
Molar mass
286.37 g/mol
EC number
636-847-3
HS code
291450
Category
Impurities and reference standards

What is 2-Hydroxyestrone?

Plain description, key identifiers and synonyms

2-hydroxyestrone is a 2-hydroxy steroid that is estrone substituted by a hydroxy group at position 2. It has a role as a human metabolite. It is a member of catechols and a 2-hydroxy steroid. It is functionally related to an estrone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,13S,14S)-2,3-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
CAS number
362-06-1 CAS number cross-checked
EC number
636-847-3
Molecular formula
C18H22O3
UNII
UQS3A06ILY
InChIKey
SWINWPBPEKHUOD-JPVZDGGYSA-N
InChI
InChI=1S/C18H22O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,19-20H,2-7H2,1H3/t11-,12+,14-,18-/m0/s1
Canonical SMILES
CC12CCC3c4cc(O)c(O)cc4CCC3C1CCC2=O
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=CC(=C(C=C34)O)O

Synonyms

  • Catecholestrone
  • 2,3-Dihydroxyestra-1,3,5(10)-trien-17-one
  • (8R,9S,13S,14S)-2,3-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
  • 2,3-dihydroxy-estra-1,3,5(10)-trien-17-one
  • Estra-1,3,5(1)-trien-17-one, 2,3-dihydroxy-
  • (8R,9S,13S,14S)-2,3-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta(a)phenanthren-17-one
  • Estra-1,3,5(10-trien-17-one, 2,3-dihydroxy)-
  • 2-OHE(1)
  • 1,3,5(10)-Estratrien-2,3-diol-17-one
  • 2-Hydroxy Estrone
  • Estrone Impurity 5
  • Estra-1,3,5(10)-trien-17-one, 2,3-dihydroxy-, 2,3-Dihydroxyestra-1,3,5(10)-trien-17-one, 2-Hydroxyestrone, Catecholestrone
  • Estra-1,3,5(10)-trien-17-one, 2,3-dihydroxy-
  • (3aS,3bR,9bS,11aS)-7,8-dihydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-one
  • 2-Hydroxyestrone 100 microg/mL in Acetonitrile
  • 2-Hydroxy estrone Solution in Acetonitrile, 100ug/mL
  • 2-Hydroxyestrone, (8R,9S,13S,14S)-2,3-dihydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
286.37 g/molcalc.
Exact mass
286.1569 Dacalc.
LogP (octanol/water)
3.52calc.
Topological polar surface area
57.53 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
21calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C1CCC1c3ccccc3CCC12

O=C1CCC2C1CCC1c3ccccc3CCC12

4 rings, 18 atoms.

176 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H351Suspected of causing cancer.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

2-Hydroxyestrone suppliers

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Where suppliers are based

1 supplier in 1 country

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2-Hydroxyestrone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anticarcinogenic Agents

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Pharmacology

2-Hydroxyestrone is a metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 2 by cytochrome P450 (CYP) enzymes, including CYP1A1 and 1A2, with potential anticarcinogenic activity. The mechanism of action for the antitumor activity of 2-hydroxyestrone is not known but this metabolic product has minimal estrogenic activity compared to the parent compound and other estrone metabolites. Additionally, O-methylation of this compound produces 2-methoxyestradiol (2-MeOE2), which is a potent inhibitor of both cell proliferation and angiogenesis.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 2-Hydroxyestrone is traded under.

HS 2914.50Indicative HS code

Ketone-phenols and ketones with other oxygen function

World exports in 2024
$438M
+10.9% vs 2023, imports $420M
2019 to 2024
Top exporters
  1. China50.5%
  2. India * partner reported11.6%
  3. United States11.3%
Top importers
  1. United States20.8%
  2. Germany10.0%
  3. Netherlands8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 2-Hydroxyestrone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 2-Hydroxyestrone, based on the data on this page

What is 2-Hydroxyestrone?

2-hydroxyestrone is a 2-hydroxy steroid that is estrone substituted by a hydroxy group at position 2. It has a role as a human metabolite. It is a member of catechols and a 2-hydroxy steroid. It is functionally related to an estrone.

What is the CAS number of 2-Hydroxyestrone?

The CAS registry number of 2-Hydroxyestrone is 362-06-1.

What is the molecular formula and weight of 2-Hydroxyestrone?

The molecular formula of 2-Hydroxyestrone is C18H22O3 and its molar mass is 286.37 g/mol.

What is 2-Hydroxyestrone used for?

Known uses and roles of 2-Hydroxyestrone include animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite, metabolite and 1 more.

Is 2-Hydroxyestrone hazardous?

2-Hydroxyestrone carries the GHS signal word "Warning". Main hazards: suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 2-Hydroxyestrone?

2-Hydroxyestrone is usually classified under HS code 291450 (Ketone-phenols and ketones with other oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 2-Hydroxyestrone?

CompoundList lists 1 supplier of 2-Hydroxyestrone in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 2-Hydroxyestrone?

Suppliers quote 2-Hydroxyestrone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 2-Hydroxyestrone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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