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Steroids and sterols

6beta-Hydroxycortisone

Also known as Hydroxycortisone, 6beta-, 6b-Hydroxycortisone, Pregn-4-ene-3,11,20-trione, 6,17,21-trihydroxy-, (6beta)-

CAS 16355-28-5Formula C21H28O6Molar mass 376.45 g/mol
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6beta-Hydroxycortisone chemical structure, C21H28O6, CAS 16355-28-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
16355-28-5
Formula
C21H28O6
Molar mass
376.45 g/mol
HS code
291440
Category
Steroids and sterols

What is 6beta-Hydroxycortisone?

Plain description, key identifiers and synonyms

6beta-hydroxycortisone is a C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6beta-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. It has a role as a probe and a human metabolite. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, a 6beta-hydroxy steroid, a 20-oxo steroid, an 11-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid. It is functionally related to a cortisone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6R,8S,9S,10R,13S,14S,17R)-6,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
CAS number
16355-28-5
Molecular formula
C21H28O6
UNII
Z40D3IQ900
MDL number
MFCD00057669
InChIKey
BCHHPSBWEQCAPG-WTCKOWDJSA-N
InChI
InChI=1S/C21H28O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15,18,22,24,27H,3-6,8-10H2,1-2H3/t12-,13-,15+,18+,19-,20-,21-/m0/s1
Canonical SMILES
CC12CCC(=O)C=C1C(O)CC1C2C(=O)CC2(C)C1CCC2(O)C(=O)CO
Isomeric SMILES
C[C@]12CCC(=O)C=C1[C@@H](C[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O

Synonyms

  • Hydroxycortisone, 6beta-
  • 6b-Hydroxycortisone
  • Pregn-4-ene-3,11,20-trione, 6,17,21-trihydroxy-, (6beta)-
  • Corticosterone, 11-dehydro-6beta,17-dihydroxy-
  • 6beta,17alpha,21-Trihydroxy-4-pregnene-3,11,20-trione
  • 6beta,17,21-trihydroxypregn-4-ene-3,11,20-trione
  • 6|A-Hydroxycortisone
  • 4-pregnene-6beta,17alpha,21-triol-3,11,20-trione
  • 6beta-17alpha,21-trihydroxypregn-4-ene-3,11,20-trione
  • Pregn-4-ene-3,11,20-trione, 6,17,21-trihydroxy-, (6.beta.)-
  • (6R,8S,9S,10R,13S,14S,17R)-6,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
376.45 g/molcalc.
Exact mass
376.1886 Dacalc.
LogP (octanol/water)
0.96calc.
Topological polar surface area
111.9 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
2calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.76calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CC(=O)C3C2CC1

O=C1C=C2CCC3C4CCCC4CC(=O)C3C2CC1

4 rings, 19 atoms.

106 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

6beta-Hydroxycortisone suppliers

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6beta-Hydroxycortisone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • probe

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 6beta-Hydroxycortisone is traded under.

HS 2914.40Indicative HS code

Ketone-alcohols and ketone-aldehydes

World exports in 2024
$199M
+2.5% vs 2023, imports $247M
2019 to 2024
Top exporters
  1. China29.5%
  2. Germany14.4%
  3. Netherlands12.7%
Top importers
  1. United States37.2%
  2. Netherlands8.5%
  3. Germany6.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 6beta-Hydroxycortisone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 6beta-Hydroxycortisone, based on the data on this page

What is 6beta-Hydroxycortisone?

6beta-hydroxycortisone is a C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6beta-position.

What is the CAS number of 6beta-Hydroxycortisone?

The CAS registry number of 6beta-Hydroxycortisone is 16355-28-5.

What is the molecular formula and weight of 6beta-Hydroxycortisone?

The molecular formula of 6beta-Hydroxycortisone is C21H28O6 and its molar mass is 376.45 g/mol.

What is 6beta-Hydroxycortisone used for?

Known uses and roles of 6beta-Hydroxycortisone include animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite, metabolite and 1 more.

Is 6beta-Hydroxycortisone hazardous?

No GHS hazard classification for 6beta-Hydroxycortisone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of 6beta-Hydroxycortisone?

6beta-Hydroxycortisone is usually classified under HS code 291440 (Ketone-alcohols and ketone-aldehydes). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 6beta-Hydroxycortisone?

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What is the price of 6beta-Hydroxycortisone?

Suppliers quote 6beta-Hydroxycortisone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 6beta-Hydroxycortisone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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