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Flavonoids and polyphenols

Amentoflavone

Also known as Didemethyl-ginkgetin, 3',8''-Biapigenin, Tridemethylsciadopitysin

CAS 1617-53-4Formula C30H18O10Molar mass 538.46 g/mol
11 suppliers listed
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Amentoflavone chemical structure, C30H18O10, CAS 1617-53-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1617-53-4
Formula
C30H18O10
Molar mass
538.46 g/mol
HS code
293299
Category
Flavonoids and polyphenols

What is Amentoflavone?

Plain description, key identifiers and synonyms

Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. It has a role as an antiviral agent, an angiogenesis inhibitor, a P450 inhibitor, a cathepsin B inhibitor and a plant metabolite. It is a hydroxyflavone, a ring assembly and a biflavonoid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
CAS number
1617-53-4 CAS number cross-checked
Molecular formula
C30H18O10
UNII
9I1VC79L77
MDL number
MFCD00017470, MFCD20275041
INCI name
AMENTOFLAVONE
InChIKey
YUSWMAULDXZHPY-UHFFFAOYSA-N
InChI
InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
SMILES (canonical and isomeric)
C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O

Synonyms

  • Didemethyl-ginkgetin
  • 3',8''-Biapigenin
  • Tridemethylsciadopitysin
  • 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
  • 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
  • 4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
  • 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • 8-(5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
  • Amenthoflavone
  • 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
  • 8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
  • I3',ii8-biapigenin
  • Ginkgetin, didemethyl-
  • med.21724, Compound 138
  • 8-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
  • AMentotaxus biflavone
  • Apigenin Impurity 3
  • 3'8''-biapigenin
  • Amentoflavone (Standard)
  • Amentoflavone, analytical standard
  • hydroxyphenyl)-5,7-dihydroxy-2-
  • Amentoflavone, >=99.0% (HPLC)
  • 3',8-Bi[4',5,7-trihydroxyflavone]
  • 4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydr
Show all 30 synonyms
  • 4',5,7-Trihydroxyflavone(3'->8)-4',5,7-trihydroxyflavone
  • (4',5,7-Trihydroxyflavone)-(3'-8)-(4',5,7-trihydroxyflavone)
  • 3''',8-Biflavone, 4',4''',5,5'',7,7''-hexahydroxy
  • 4',4''',5,5'',7,7''-Hexahydroxy-3''',8-biflavone, 8CI
  • 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
538.46 g/molcalc.
Exact mass
538.09 Dacalc.
LogP (octanol/water)
5.13calc.
Topological polar surface area
181.8 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
3calc.
Heavy atoms
40calc.
Rings
6calc.
Aromatic rings
6calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2cccc(-c3cccc4c(=O)cc(-c5ccccc5)oc34)c2)oc2ccccc12

O=c1cc(-c2cccc(-c3cccc4c(=O)cc(-c5ccccc5)oc34)c2)oc2ccccc12

6 rings, 34 atoms.

20 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Amentoflavone suppliers

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All 11 suppliers
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Where suppliers are based

11 suppliers in 3 countries

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Amentoflavone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name AMENTOFLAVONE(antioxidant, bleaching)

Pharmacological actions

  • Cytochrome P-450 CYP2C9 Inhibitors
  • Cytochrome P-450 CYP3A Inhibitors

Roles

  • P450 inhibitor
  • angiogenesis inhibitor
  • antimicrobial agent
  • antiviral agent
  • cathepsin B inhibitor
  • cysteine protease inhibitor
  • enzyme inhibitor
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite
  • protease inhibitor

Functional uses

  • Antioxidant
  • Bleaching agent

Cosmetic functions

  • Antioxidant
  • Bleaching

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Amentoflavone is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Amentoflavone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Amentoflavone, based on the data on this page

What is Amentoflavone?

Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum.

What is the CAS number of Amentoflavone?

The CAS registry number of Amentoflavone is 1617-53-4.

What is the molecular formula and weight of Amentoflavone?

The molecular formula of Amentoflavone is C30H18O10 and its molar mass is 538.46 g/mol.

What is Amentoflavone used for?

Known uses and roles of Amentoflavone include antioxidants in cosmetics and personal care, skin conditioning agents in cosmetics and personal care, p450 inhibitor, angiogenesis inhibitor, antimicrobial agent and 14 more.

Is Amentoflavone hazardous?

No GHS hazard classification for Amentoflavone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Amentoflavone?

Amentoflavone is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Amentoflavone?

CompoundList lists 11 suppliers of Amentoflavone in China, Israel and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Amentoflavone?

Suppliers quote Amentoflavone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Amentoflavone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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