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Flavonoids and polyphenols

Luteolin

Also known as 3',4',5,7-Tetrahydroxyflavone, Digitoflavone, Luteolol

CAS 491-70-3Formula C15H10O6Molar mass 286.24 g/molEC 207-741-0
GHS signal word: Warning. Pictograms: Harmful or irritant 131 suppliers listed
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Luteolin chemical structure, C15H10O6, CAS 491-70-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
491-70-3
Formula
C15H10O6
Molar mass
286.24 g/mol
EC number
207-741-0
HS code
293299
Category
Flavonoids and polyphenols

What is Luteolin?

Plain description, key identifiers and synonyms

Luteolin is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. It has a role as an antineoplastic agent, an angiogenesis inhibitor, a radical scavenger, an immunomodulator, a vascular endothelial growth factor receptor antagonist, an anti-inflammatory agent, an apoptosis inducer, an EC 2.3.1.85 (fatty acid synthase) inhibitor, a nephroprotective agent, a plant metabolite and a c-Jun N-terminal kinase inhibitor. It is a 3'-hydroxyflavonoid and a tetrahydroxyflavone. It is a conjugate acid of a luteolin-7-olate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
CAS number
491-70-3 CAS number cross-checkedOther or deprecated CAS: 1318-21-4
EC number
207-741-0
Molecular formula
C15H10O6
UNII
KUX1ZNC9J2
MDL number
MFCD00017309
INCI name
LUTEOLIN
InChIKey
IQPNAANSBPBGFQ-UHFFFAOYSA-N
InChI
InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
SMILES (canonical and isomeric)
C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

Synonyms

  • 3',4',5,7-Tetrahydroxyflavone
  • Digitoflavone
  • Luteolol
  • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
  • Flacitran
  • Luteoline
  • Salifazide
  • Yama kariyasu
  • Weld Lake
  • 5,7,3',4'-Tetrahydroxyflavone
  • Cyanidenon-1470
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
  • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone
  • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
  • 3',4',5,7-Tetrahydroxy-Flavone
  • Cyanidenon 1470
  • Bismite
  • Luteolin (Standard)
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one
  • Flavone, 3',4',5,7-tetrahydroxy-
  • C.I. Natural Yellow 2
  • Luteoin
  • Daphneflavonol,
  • Digitoflavone,
Show all 34 synonyms
  • Lutl
  • Flavopurpol,
  • Luteolin?
  • C.I. 75590
  • 4dew
  • 4dgn
  • 4hkn
  • Luteoline(Standard)
  • DIOSMETIN_met006

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
286.24 g/molcalc.
Exact mass
286.0477 Dacalc.
LogP (octanol/water)
2.28calc.
Topological polar surface area
111.1 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
1calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2ccccc12

O=c1cc(-c2ccccc2)oc2ccccc12

3 rings, 17 atoms, the Flavone ring system.

2,273 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Luteolin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 131 suppliers
30 of 30 offers

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Where suppliers are based

131 suppliers in 18 countries

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Luteolin price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name LUTEOLIN(skin conditioning)

Roles

  • angiogenesis inhibitor
  • antagonist
  • anti-inflammatory agent
  • antineoplastic agent
  • antioxidant
  • apoptosis inducer
  • c-Jun N-terminal kinase inhibitor
  • enzyme inhibitor
  • eukaryotic metabolite
  • immunomodulator
  • metabolite
  • nephroprotective agent
  • pharmaceutical
  • plant metabolite
  • protective agent
  • protein kinase inhibitor
  • radical scavenger
  • vascular endothelial growth factor receptor antagonist

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Luteolin is a naturally-occurring flavonoid, with potential anti-oxidant, anti-inflammatory, apoptosis-inducing and chemopreventive activities. Upon administration, luteolin scavenges free radicals, protects cells from reactive oxygen species (ROS)-induced damage and induces direct cell cycle arrest and apoptosis in tumor cells. This inhibits tumor cell proliferation and suppresses metastasis.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Luteolin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Luteolin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Luteolin, based on the data on this page

What is Luteolin?

Luteolin is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.

What is the CAS number of Luteolin?

The CAS registry number of Luteolin is 491-70-3. Other or deprecated CAS numbers: 1318-21-4.

What is the molecular formula and weight of Luteolin?

The molecular formula of Luteolin is C15H10O6 and its molar mass is 286.24 g/mol.

What is Luteolin used for?

Known uses and roles of Luteolin include skin conditioning agents in cosmetics and personal care, angiogenesis inhibitor, antagonist, anti-inflammatory agent, antineoplastic agent and 16 more.

Is Luteolin hazardous?

Luteolin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Luteolin?

Luteolin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Luteolin?

CompoundList lists 131 suppliers of Luteolin in China, United States, Germany, United Kingdom and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Luteolin in India?

3 suppliers in India list Luteolin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Luteolin?

Suppliers quote Luteolin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Luteolin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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