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Aromatic building blocks

Amonafide

Also known as Nafidimide, Benzisoquinolinedione, Amonafida

CAS 69408-81-7Formula C16H17N3O2Molar mass 283.33 g/mol
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Amonafide chemical structure, C16H17N3O2, CAS 69408-81-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
69408-81-7
Formula
C16H17N3O2
Molar mass
283.33 g/mol
Solubility
H <1 (mg/mL)
HS code
292519
Category
Aromatic building blocks

What is Amonafide?

Plain description, key identifiers and synonyms

5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione is a member of isoquinolines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione
CAS number
69408-81-7 CAS number cross-checked
Molecular formula
C16H17N3O2
UNII
1Q8D39N37L
MDL number
MFCD00866438
InChIKey
UPALIKSFLSVKIS-UHFFFAOYSA-N
InChI
InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
SMILES (canonical and isomeric)
CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N

Synonyms

  • Nafidimide
  • Benzisoquinolinedione
  • Amonafida
  • Amonafidum
  • 3-Amino-N-(2-(dimethylamino)ethyl)naphthalimide
  • 1H-Benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)-
  • 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
  • 5-amino-2-(2-(dimethylamino)ethyl)-1H-benz(de)isoquinoline-1,3(2H)-dione
  • MFA 142
  • 5-amino-2-(2-dimethylaminoethyl)benzo(de)isoquinolin-1,3-dione
  • 1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)
  • 11-amino-3-(2-(dimethylamino)ethyl)-3-azatricyclo(7.3.1.0?,13)trideca-1(13),5,7,9,11-pentaene-2,4-dione
  • Quinamed
  • 5-Aminomitonafide
  • 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione
  • M-FA 142
  • FA 142
  • 5-amino-2-(2-(dimethylamino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
  • Amonifide
  • Amonafide (USAN)
  • 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
  • Naphthalimide, 3-amino-N-(2-(dimethylamino)ethyl)-
  • 5-Amino-2-(2-dimethylamino-ethyl)-benzo[de]isoquinoline-1,3-dione
  • Amonofide
  • BIDA
Show all 30 synonyms
  • 3-Amino-N-(2-(dimethylamino)ethyl)-1,8-naphthalindicarboximid
  • 1H-Benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(dimethylamino)ethyl-
  • 5-amino-2-(2-dimethylaminoethyl)benzo[de]isoquinoline-1,3-dione
  • 5-amino-2-(2-dimethylaminoethyl)ben
  • 1H-Benz[de]isoquinoline-1, 5-amino-2-[2-(dimethylamino)ethyl]-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
H <1 (mg/mL)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
283.33 g/molcalc.
Exact mass
283.1321 Dacalc.
LogP (octanol/water)
1.58calc.
Topological polar surface area
66.64 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NC(=O)c2cccc3cccc1c23

O=C1NC(=O)c2cccc3cccc1c23

3 rings, 15 atoms, the Naphthalimide ring system.

306 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Amonafide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 2 countries

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Amonafide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Antiviral Agents
  • Enzyme Inhibitors
  • Intercalating Agents

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Amonafide is an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Amonafide is traded under.

HS 2925.19Indicative HS code

Imides and their derivatives, salts thereof, other

World exports in 2024
$295M
+11.7% vs 2023, imports $348M
2019 to 2024
Top exporters
  1. China29.7%
  2. Japan22.7%
  3. United Kingdom10.0%
Top importers
  1. United States12.7%
  2. Brazil12.6%
  3. China10.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Amonafide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Amonafide, based on the data on this page

What is Amonafide?

5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione is a member of isoquinolines.

What is the CAS number of Amonafide?

The CAS registry number of Amonafide is 69408-81-7.

What is the molecular formula and weight of Amonafide?

The molecular formula of Amonafide is C16H17N3O2 and its molar mass is 283.33 g/mol.

What is Amonafide used for?

Known uses and roles of Amonafide include building blocks in research and laboratory, screening compounds in research and laboratory, biochemical and pharmacological tools in research and laboratory, antineoplastic agent, pharmaceutical and 4 more.

Is Amonafide hazardous?

No GHS hazard classification for Amonafide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Amonafide?

Amonafide is usually classified under HS code 292519 (Imides and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Amonafide?

CompoundList lists 3 suppliers of Amonafide in China and Australia. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Amonafide?

Suppliers quote Amonafide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Amonafide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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