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Screening compounds

Apitolisib

Also known as GNE 390, RG 7422, Gne-390

CAS 1032754-93-0Formula C23H30N8O3SMolar mass 498.61 g/mol
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Apitolisib chemical structure, C23H30N8O3S, CAS 1032754-93-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1032754-93-0
Formula
C23H30N8O3S
Molar mass
498.61 g/mol
HS code
293499
Category
Screening compounds

What is Apitolisib?

Plain description, key identifiers and synonyms

Apitolisib is an orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Apitolisib inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy, mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-1-[4-[[2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
CAS number
1032754-93-0 CAS number cross-checked
Molecular formula
C23H30N8O3S
UNII
1C854K1MIJ
MDL number
MFCD20274520
InChIKey
YOVVNQKCSKSHKT-HNNXBMFYSA-N
InChI
InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
Canonical SMILES
Cc1c(CN2CCN(C(=O)C(C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12
Isomeric SMILES
CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O

Synonyms

  • GNE 390
  • RG 7422
  • Gne-390
  • (2s)-1-(4-{[2-(2-Aminopyrimidin-5-Yl)-7-Methyl-4-(Morpholin-4-Yl)thieno[3,2-D]pyrimidin-6-Yl]methyl}piperazin-1-Yl)-2-Hydroxypropan-1-One
  • (2S)-1-[4-[[2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
  • apitolisibum
  • (2S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
  • (2S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
  • GDC-0980 (RG7422)
  • (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
  • GDC 0980
  • GDC-0980 (Apitolisib)
  • Apitolisib (USAN/INN)
  • Apitolisib (GDC-0980)
  • GDC-0980,CAS:1032754-93-0
  • GNE 390, GDC 0980, RG 7422
  • 1-Propanone, 1-(4-((2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)thieno(3,2-d)pyrimidin-6-yl)methyl)-1-piperazinyl)-2-hydroxy-, (2S)-
  • 1-Propanone, 1-[4-[[2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-2-hydroxy-, (2S)-
  • Apitolisib(GDC-0980)?
  • GDC-0980,RG7422
  • US12324807, Compound Apitolisib
  • Sdccgsbi-0654434.p001
  • Apitolisib (GDC-0980, RG7422)
  • (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperaz
  • (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one.
Show all 30 synonyms
  • CAS:1032754-93-0, GDC-0980
  • (2S)-1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno(3,2-d)pyrimidin-6-yl)methyl(piperazin-1-yl)-2-hydroxypropan-1-one
  • (2S)-1-[4-[[2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholino-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxy-propan-1-one
  • (S)-1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno(3,2-d)pyrimidin-6-yl)methyl)piperazi
  • (S)-1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
498.61 g/molcalc.
Exact mass
498.2162 Dacalc.
LogP (octanol/water)
0.9calc.
Topological polar surface area
133.8 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
11calc.
Rotatable bonds
5calc.
Heavy atoms
35calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ncc(-c2nc(N3CCOCC3)c3sc(CN4CCNCC4)cc3n2)cn1

c1ncc(-c2nc(N3CCOCC3)c3sc(CN4CCNCC4)cc3n2)cn1

5 rings, 28 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Apitolisib suppliers

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Where suppliers are based

4 suppliers in 2 countries

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Apitolisib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Apitolisib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Apitolisib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Apitolisib, based on the data on this page

What is Apitolisib?

Apitolisib is an orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity.

What is the CAS number of Apitolisib?

The CAS registry number of Apitolisib is 1032754-93-0.

What is the molecular formula and weight of Apitolisib?

The molecular formula of Apitolisib is C23H30N8O3S and its molar mass is 498.61 g/mol.

What is Apitolisib used for?

Known uses and roles of Apitolisib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Apitolisib hazardous?

No GHS hazard classification for Apitolisib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Apitolisib?

Apitolisib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Apitolisib?

CompoundList lists 4 suppliers of Apitolisib in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Apitolisib?

Suppliers quote Apitolisib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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