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Heterocyclic building blocks

Avotaciclib

Also known as 2,6-Bis(2-aminopyrimidin-4-yl)pyridin-3-ol, CDK1 inhibitor BEY1107, 3-Pyridinol, 2,6-bis(2-amino-4-pyrimidinyl)-

CAS 1983983-41-0Formula C13H11N7OMolar mass 281.28 g/mol
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Avotaciclib chemical structure, C13H11N7O, CAS 1983983-41-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1983983-41-0
Formula
C13H11N7O
Molar mass
281.28 g/mol
HS code
293359
Category
Heterocyclic building blocks

What is Avotaciclib?

Plain description, key identifiers and synonyms

Avotaciclib is an orally bioavailable, cyclin dependent kinase 1 (CDK1) inhibitor, with potential antineoplastic activity. Upon administration, avotaciclib targets, binds to and inhibits the activity of CDK1. This may inhibit cancer stem cell (CSC) division, cause cell cycle arrest, and induce apoptosis. This may inhibit tumor cell proliferation. CDK1, an ATP-dependent serine/threonine kinase, plays a key role in regulating cell division, cell cycle progression and proliferation. It is frequently overexpressed in tumor cells.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol
CAS number
1983983-41-0
Molecular formula
C13H11N7O
UNII
Z6BYC0F36E
InChIKey
VFVAQKKPFOPZEA-UHFFFAOYSA-N
InChI
InChI=1S/C13H11N7O/c14-12-16-5-3-8(19-12)7-1-2-10(21)11(18-7)9-4-6-17-13(15)20-9/h1-6,21H,(H2,14,16,19)(H2,15,17,20)
SMILES (canonical and isomeric)
C1=CC(=NC(=C1O)C2=NC(=NC=C2)N)C3=NC(=NC=C3)N

Synonyms

  • 2,6-Bis(2-aminopyrimidin-4-yl)pyridin-3-ol
  • CDK1 inhibitor BEY1107
  • 3-Pyridinol, 2,6-bis(2-amino-4-pyrimidinyl)-
  • BEY-A
  • BEY 1107
  • 2,6-Bis(2-amino-4-pyrimidinyl)-3-pyridinol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
281.28 g/molcalc.
Exact mass
281.1025 Dacalc.
LogP (octanol/water)
0.87calc.
Topological polar surface area
136.7 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
2calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(-c2ccncn2)nc(-c2ccncn2)c1

c1cc(-c2ccncn2)nc(-c2ccncn2)c1

3 rings, 18 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Avotaciclib suppliers

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Avotaciclib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Avotaciclib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Avotaciclib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Avotaciclib, based on the data on this page

What is Avotaciclib?

Avotaciclib is an orally bioavailable, cyclin dependent kinase 1 (CDK1) inhibitor, with potential antineoplastic activity. Upon administration, avotaciclib targets, binds to and inhibits the activity of CDK1. This may inhibit cancer stem cell (CSC) division, cause cell cycle arrest, and induce apoptosis.

What is the CAS number of Avotaciclib?

The CAS registry number of Avotaciclib is 1983983-41-0.

What is the molecular formula and weight of Avotaciclib?

The molecular formula of Avotaciclib is C13H11N7O and its molar mass is 281.28 g/mol.

What is Avotaciclib used for?

Known uses and roles of Avotaciclib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Avotaciclib hazardous?

No GHS hazard classification for Avotaciclib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Avotaciclib?

Avotaciclib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Avotaciclib?

Post a free request on CompoundList and suppliers of Avotaciclib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Avotaciclib?

Suppliers quote Avotaciclib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Avotaciclib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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