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Oncology and immunology drugs

Azacytidine

Also known as 5-azacytidine, Azacitidine, Ladakamycin

CAS 320-67-2Formula C8H12N4O5Molar mass 244.21 g/molEC 206-280-2
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 158 suppliers listed Drug substance
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Azacytidine chemical structure, C8H12N4O5, CAS 320-67-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from methanol
Melting point
228 to 230
Solubility
5 to 10 mg/mL at 70 °F
HS code
293499
Category
Oncology and immunology drugs
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Azacytidine?

Plain description, key identifiers and synonyms

5-azacytidine is an N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia. It has a role as an antineoplastic agent. It is a N-glycosyl-1,3,5-triazine and a nucleoside analogue. It is functionally related to a beta-D-ribose.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
CAS number
320-67-2 CAS number cross-checkedOther or deprecated CAS: 1401238-97-8
EC number
206-280-2
Molecular formula
C8H12N4O5
UNII
M801H13NRU
MDL number
MFCD00006539
InChIKey
NMUSYJAQQFHJEW-KVTDHHQDSA-N
InChI
InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
Canonical SMILES
Nc1ncn(C2OC(CO)C(O)C2O)c(=O)n1
Isomeric SMILES
C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N

Synonyms

  • 5-azacytidine
  • Azacitidine
  • Ladakamycin
  • Mylosar
  • 5-azacitidine
  • Azacitidina
  • Azacitidinum
  • Antibiotic U 18496
  • Onureg
  • 4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one
  • 4-Amino-1-beta-d-ribofuranosyl-1,3,5-triazin-2(1H)-one
  • 5-AZCR
  • 1,3,5-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-
  • 5 AZC
  • 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
  • s-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-
  • 5 Azacytidine
  • 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
  • azacitidine for
  • 4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1,2-dihydro-1,3,5-triazin-2-one
  • 4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1,3,5-triazin-2-one
  • Azacitidine azacitidine
  • 4-Amino-1-beta-D-ribofuranosyl-D-triazin-2(1H)-one
  • 5'-Azacytidine
  • Vidaza
Show all 34 synonyms
  • 5-AZAC
  • 5-aza-CR
  • 4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one
  • Azacitidinum (INN-Latin)
  • Azacitidina (INN-Spanish)
  • 5-Aza-xylo-cytidine
  • 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3,5-triazin-2-one
  • 4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
  • Vidaza (TN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from methanolexp.
Melting point
228 to 230exp.
Solubility
5 to 10 mg/mL at 70 °Fexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
244.21 g/molcalc.
Exact mass
244.0808 Dacalc.
LogP (octanol/water)
-3.17calc.
Topological polar surface area
143.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
2calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.63calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ncncn1C1CCCO1

O=c1ncncn1C1CCCO1

2 rings, 12 atoms.

41 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H350May cause cancer.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Azacytidine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 158 suppliers
30 of 30 offers

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Where suppliers are based

158 suppliers in 28 countries

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Azacytidine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Anticancer agent used to treat acute myclogenous leukemia.

Pharmacological actions

  • Antimetabolites, Antineoplastic
  • Enzyme Inhibitors

Roles

  • anti-anaemic agent
  • antibacterial agent
  • antibacterial drug
  • antifibrotic agent
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antimycobacterial drug
  • antineoplastic agent
  • antitubercular agent
  • pharmaceutical
  • protective agent
  • renoprotective agent

Pharmacology

Azacitidine is a Nucleoside Metabolic Inhibitor. The mechanism of action of azacitidine is as a Nucleic Acid Synthesis Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Azacytidine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Azacytidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Azacytidine, based on the data on this page

What is Azacytidine?

5-azacytidine is an N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia. It has a role as an antineoplastic agent.

What is the CAS number of Azacytidine?

The CAS registry number of Azacytidine is 320-67-2. Other or deprecated CAS numbers: 1401238-97-8.

What is the molecular formula and weight of Azacytidine?

The molecular formula of Azacytidine is C8H12N4O5 and its molar mass is 244.21 g/mol.

What is Azacytidine used for?

Anticancer agent used to treat acute myclogenous leukemia.

Is Azacytidine hazardous?

Azacytidine carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Azacytidine?

Azacytidine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Azacytidine?

CompoundList lists 158 suppliers of Azacytidine in China, India, United States, Germany and 24 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Azacytidine in India?

32 suppliers in India list Azacytidine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Azacytidine?

Suppliers quote Azacytidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Azacytidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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