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Nucleosides and nucleotides

Ribavirin

Also known as Tribavirin, Rebetol, Virazole

CAS 36791-04-5Formula C8H12N4O5Molar mass 244.21 g/molEC 636-825-3
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 112 suppliers listed Drug substance
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Ribavirin chemical structure, C8H12N4O5, CAS 36791-04-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless
Melting point
166 to 168
Solubility
Water-soluble
HS code
293499
Category
Nucleosides and nucleotides
Illustrative photo, a white jumbo bulk bag of powder in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Ribavirin?

Plain description, key identifiers and synonyms

Ribavirin is a 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses. It has a role as an anticoronaviral agent, an antiviral agent, an antimetabolite, an antiinfective agent and an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor. It is a primary carboxamide, a monocarboxylic acid amide, an aromatic amide and a 1-ribosyltriazole. It is functionally related to a 1,2,4-triazole-3-carboxamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
CAS number
36791-04-5 CAS number cross-checkedOther or deprecated CAS: 252269-50-4, 66510-90-5
EC number
636-825-3
Molecular formula
C8H12N4O5
UNII
49717AWG6K
MDL number
MFCD00058564
InChIKey
IWUCXVSUMQZMFG-AFCXAGJDSA-N
InChI
InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
SMILES
C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N

Synonyms

  • Tribavirin
  • Rebetol
  • Virazole
  • Copegus
  • Ribamidil
  • Ribavirine
  • Vilona
  • Viramid
  • Ribasphere
  • RTCA
  • Ribavirina
  • Varazid
  • Ribavirinum
  • Cotronak
  • 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
  • Virazid
  • Ribavirin Mylan
  • Ribavirin Teva
  • 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
  • Ribavirin BioPartners
  • SCH 18908
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
  • Ribavirin Teva Pharma B.V.
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
  • ribofluranosyl carboxamide
Show all 36 synonyms
  • 1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl-
  • Ribovirin
  • Viramide
  • Ribavarin
  • ICN 1229
  • Ribapak
  • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1,2,4-triazole-3-carboxamide
  • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1H-1,2,4-triazole-3-carboxamide
  • 1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide
  • 1-beta-d-ribofuranosyl-1h-1,2, 4-triazole-3-carboxamide
  • Ribamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorlessexp.
Odour
Odorlessexp.
Taste
Tastelessexp.
Melting point
166 to 168exp.
Solubility
Water-solubleexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
244.21 g/molcalc.
Exact mass
244.0808 Dacalc.
LogP (octanol/water)
-3.01calc.
Topological polar surface area
143.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
3calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.63calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ncn(C2CCCO2)n1

c1ncn(C2CCCO2)n1

2 rings, 10 atoms.

61 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H341Suspected of causing genetic defects.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (20)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ribavirin suppliers

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All 112 suppliers
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Where suppliers are based

112 suppliers in 20 countries

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Ribavirin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antiviral.

Indicated for the aerosol treatment of carefully selected hospitalized infants and young children with severe lower respiratory tract infection due to respiratory syncytial virus.

Antimetabolites, Antiviral Agents.

Broad spectrum of activity against many RNA and DNA viruses, both in vitro and in vivo.

Pharmacological actions

  • Antimetabolites
  • Antiviral Agents

Roles

  • DNA polymerase inhibitor
  • anti-HBV agent
  • anti-HIV agent
  • anticoronaviral agent
  • antidepressant
  • antifibrotic agent
  • antiinfective agent
  • antimetabolite
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • central nervous system drug
  • enzyme inhibitor
  • hepatoprotective agent
  • hypoglycemic agent
  • pharmaceutical
  • protective agent
  • psychotropic drug

Pharmacology

Ribavirin is a Nucleoside Analog Antiviral.

How it is made

Synthesis: Acid-catalyzed fusion of methyl 1,2,4-triazole-3-carboxylate and 1,2,3,5-tetra-O-acetyl--d-ribofuranose or 1-O-acetyl-2,3,5-tri-O-benzoyl--d-ribofuranose yields blocked methyl ester nucleosides. Ribavirin is obtained after treatment of the blocked nucleoside with methanolic NH3.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ribavirin is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Ribavirin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ribavirin, based on the data on this page

What is Ribavirin?

Ribavirin is a 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses.

What is the CAS number of Ribavirin?

The CAS registry number of Ribavirin is 36791-04-5. Other or deprecated CAS numbers: 252269-50-4, 66510-90-5.

What is the molecular formula and weight of Ribavirin?

The molecular formula of Ribavirin is C8H12N4O5 and its molar mass is 244.21 g/mol.

What is Ribavirin used for?

Therapeutic category: Antiviral. Indicated for the aerosol treatment of carefully selected hospitalized infants and young children with severe lower respiratory tract infection due to respiratory syncytial virus. Antimetabolites, Antiviral Agents.

Is Ribavirin hazardous?

Ribavirin carries the GHS signal word "Danger". Main hazards: may cause an allergic skin reaction, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ribavirin?

Ribavirin is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ribavirin?

CompoundList lists 112 suppliers of Ribavirin in United States, China, India, Germany and 16 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ribavirin in India?

7 suppliers in India list Ribavirin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ribavirin?

Suppliers quote Ribavirin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ribavirin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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