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Screening compounds

Azd-8330

Also known as AZD 8330, 2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide, ARRY-704

CAS 869357-68-6Formula C16H17FIN3O4Molar mass 461.23 g/molEC 642-441-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 7 suppliers listed
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Azd-8330 chemical structure, C16H17FIN3O4, CAS 869357-68-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
869357-68-6
Formula
C16H17FIN3O4
Molar mass
461.23 g/mol
EC number
642-441-7
HS code
293339
Category
Screening compounds

What is Azd-8330?

Plain description, key identifiers and synonyms

2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide
CAS number
869357-68-6 CAS number cross-checkedOther or deprecated CAS: 1204531-17-8
EC number
642-441-7
Molecular formula
C16H17FIN3O4
UNII
G4990BOZ66
MDL number
MFCD18384989
InChIKey
RWEVIPRMPFNTLO-UHFFFAOYSA-N
InChI
InChI=1S/C16H17FIN3O4/c1-9-7-11(15(23)20-25-6-5-22)14(21(2)16(9)24)19-13-4-3-10(18)8-12(13)17/h3-4,7-8,19,22H,5-6H2,1-2H3,(H,20,23)
SMILES (canonical and isomeric)
CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO

Synonyms

  • AZD 8330
  • 2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  • ARRY-704
  • 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  • 2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide
  • 2-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  • 2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide
  • MEK Inhibitor AZD8330
  • ARRY-424704, ARRY-704
  • 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide
  • ARRY704
  • ARRY 424704
  • Sdccgsbi-0654391.p001
  • 2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide.
  • US11147816, AZD8330
  • AZD8330,ARRY-424704, ARRY-704
  • AZD8330(ARRY-424704, ARRY-704)
  • AZD8330(ARRY-424704, ARRY-704)?
  • 2-(2-fluoro-4-iodo-anilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-pyridine-3-carboxamide
  • 2-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  • 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxyl)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  • 3-Pyridinecarboxamide, 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
461.23 g/molcalc.
Exact mass
461.0248 Dacalc.
LogP (octanol/water)
1.83calc.
Topological polar surface area
92.59 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
25calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cccc(Nc2ccccc2)[nH]1

O=c1cccc(Nc2ccccc2)[nH]1

2 rings, 14 atoms.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (9)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Azd-8330 suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 7 suppliers
7 of 7 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

7 suppliers in 2 countries

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Azd-8330 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

MEK Inhibitor AZD8330 is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth, constitutive activation of this pathway has been implicated in many cancers.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Azd-8330 is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Azd-8330 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Azd-8330, based on the data on this page

What is Azd-8330?

2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

What is the CAS number of Azd-8330?

The CAS registry number of Azd-8330 is 869357-68-6. Other or deprecated CAS numbers: 1204531-17-8.

What is the molecular formula and weight of Azd-8330?

The molecular formula of Azd-8330 is C16H17FIN3O4 and its molar mass is 461.23 g/mol.

What is Azd-8330 used for?

Known uses and roles of Azd-8330 include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Azd-8330 hazardous?

Azd-8330 carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Azd-8330?

Azd-8330 is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Azd-8330?

CompoundList lists 7 suppliers of Azd-8330 in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Azd-8330?

Suppliers quote Azd-8330 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Azd-8330

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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