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Screening compounds

Briciclib

Also known as 2-Methoxy-5-(((2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)phenyl dihydrogen phosphate, briciclibum, (2-methoxy-5-(((E)-2-(2,4,6-trimethoxyphenyl)ethenesulfonyl)methyl)phenoxy)phosphonic acid

CAS 865783-99-9Formula C19H23O10PSMolar mass 474.42 g/mol
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Briciclib chemical structure, C19H23O10PS, CAS 865783-99-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
865783-99-9
Formula
C19H23O10PS
Molar mass
474.42 g/mol
HS code
293090
Category
Screening compounds

What is Briciclib?

Plain description, key identifiers and synonyms

Briciclib is a benzyl styryl sulfone analog, and a phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, briciclib is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. suppresses cyclin D1 accumulation in cancer cells.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] dihydrogen phosphate
CAS number
865783-99-9
Molecular formula
C19H23O10PS
UNII
WG93X96336
MDL number
MFCD22665751
InChIKey
LXENKEWVEVKKGV-BQYQJAHWSA-N
InChI
InChI=1S/C19H23O10PS/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22/h5-11H,12H2,1-4H3,(H2,20,21,22)/b8-7+
Canonical SMILES
COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(OP(=O)(O)O)c2)c(OC)c1
Isomeric SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)OP(=O)(O)O

Synonyms

  • 2-Methoxy-5-(((2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)phenyl dihydrogen phosphate
  • briciclibum
  • (2-methoxy-5-(((E)-2-(2,4,6-trimethoxyphenyl)ethenesulfonyl)methyl)phenoxy)phosphonic acid
  • (2-methoxy-5-{[(E)-2-(2,4,6-trimethoxyphenyl)ethenesulfonyl]methyl}phenoxy)phosphonic acid
  • Briciclib (ON-013105)
  • (E)-2-Methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl dihydrogen phosphate
  • Briciclib (ON-014185)
  • ON 014185
  • Phenol, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, 1-(dihydrogen phosphate)
  • [2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] dihydrogen phosphate
  • Phenol, 2-methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)-, 1-(dihydrogen phosphate)
  • (E)-2-Methoxy-5-[[(2,4,6-trimethoxystyryl)sulfonyl]methyl]phenyl Dihydrogen Phosphate
  • 865783-99-9 (free acid)
  • Briciclib (USAN/INN)
  • Briciclib, ON 014185
  • Briciclib(ON 013105,ON 014185)
  • Briciclib(ON 013105,ON 014185)?
  • (e)-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenyl dihydrogen phosphate
  • (E)-5-(((2,4,6-Trimethoxystyryl)sulfonyl)methyl)-2-methoxyphenyl dihydrogen phosphate
  • [2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonylmethyl]phenyl] dihydrogen phosphate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
474.42 g/molcalc.
Exact mass
474.075 Dacalc.
LogP (octanol/water)
2.78calc.
Topological polar surface area
137.8 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
10calc.
Heavy atoms
31calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S(=O)(C=Cc1ccccc1)Cc1ccccc1

O=S(=O)(C=Cc1ccccc1)Cc1ccccc1

2 rings, 18 atoms.

17 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Briciclib suppliers

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Briciclib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Briciclib is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Briciclib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Briciclib, based on the data on this page

What is Briciclib?

Briciclib is a benzyl styryl sulfone analog, and a phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, briciclib is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D.

What is the CAS number of Briciclib?

The CAS registry number of Briciclib is 865783-99-9.

What is the molecular formula and weight of Briciclib?

The molecular formula of Briciclib is C19H23O10PS and its molar mass is 474.42 g/mol.

What is Briciclib used for?

Known uses and roles of Briciclib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Briciclib hazardous?

No GHS hazard classification for Briciclib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Briciclib?

Briciclib is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Briciclib?

Post a free request on CompoundList and suppliers of Briciclib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Briciclib?

Suppliers quote Briciclib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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