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Flavonoids and polyphenols

Combretol

Also known as 5-hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one, 5-Hydroxy-3,3',4',5',7-pentamethoxyflavone, 5-Hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one

CAS 5084-19-5Formula C20H20O8Molar mass 388.37 g/mol
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Combretol chemical structure, C20H20O8, CAS 5084-19-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
5084-19-5
Formula
C20H20O8
Molar mass
388.37 g/mol
HS code
293299
Category
Flavonoids and polyphenols

What is Combretol?

Plain description, key identifiers and synonyms

Combretol is a pentamethoxyflavone that is myricetin in which the hydroxy groups at positions 3, 7, 3', 4' and 5' have been replaced by methoxy groups. It has been isolated from Combretum quadrangulare. It has a role as a metabolite, an antileishmanial agent and a plant metabolite. It is a monohydroxyflavone and a pentamethoxyflavone. It is functionally related to a myricetin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one
CAS number
5084-19-5 CAS number cross-checked
Molecular formula
C20H20O8
UNII
2G3ZF4VTE5
InChIKey
SUNUQCQIFHHEOW-UHFFFAOYSA-N
InChI
InChI=1S/C20H20O8/c1-23-11-8-12(21)16-13(9-11)28-18(20(27-5)17(16)22)10-6-14(24-2)19(26-4)15(7-10)25-3/h6-9,21H,1-5H3
SMILES (canonical and isomeric)
COC1=CC(=C2C(=C1)OC(=C(C2=O)OC)C3=CC(=C(C(=C3)OC)OC)OC)O

Synonyms

  • 5-hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one
  • 5-Hydroxy-3,3',4',5',7-pentamethoxyflavone
  • 5-Hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one
  • 5-Hydroxy-3',3,4',5',7-pentamethoxyflavone
  • 3,7,3',4',5'-Penta-O-methylmyricetin
  • Flavone, 5-hydroxy-3,3',4',5',7-pentamethoxy-
  • 5-Hydroxy-3'',3,4'',5'',7-pentamethoxyflavone
  • 5-Hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one
  • 3,7,3',4',5'-pentamethylmyricetin
  • myricetin-3,7,3',4',5'-pentamethylether
  • myricetin 3,7,3',4',5'-pentamethyl ether
  • 4H-1-Benzopyran-4-one, 5-hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
388.37 g/molcalc.
Exact mass
388.1158 Dacalc.
LogP (octanol/water)
3.21calc.
Topological polar surface area
96.59 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
6calc.
Heavy atoms
28calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2ccccc12

O=c1cc(-c2ccccc2)oc2ccccc12

3 rings, 17 atoms, the Flavone ring system.

2,273 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Combretol suppliers

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Combretol price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antiinfective agent
  • antileishmanial agent
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiprotozoal drug
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Combretol is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Combretol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Combretol, based on the data on this page

What is Combretol?

Combretol is a pentamethoxyflavone that is myricetin in which the hydroxy groups at positions 3, 7, 3', 4' and 5' have been replaced by methoxy groups. It has been isolated from Combretum quadrangulare. It has a role as a metabolite, an antileishmanial agent and a plant metabolite.

What is the CAS number of Combretol?

The CAS registry number of Combretol is 5084-19-5.

What is the molecular formula and weight of Combretol?

The molecular formula of Combretol is C20H20O8 and its molar mass is 388.37 g/mol.

What is Combretol used for?

Known uses and roles of Combretol include antiinfective agent, antileishmanial agent, antimicrobial agent, antimicrobial drug, antiparasitic agent and 5 more.

Is Combretol hazardous?

No GHS hazard classification for Combretol is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Combretol?

Combretol is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Combretol?

Post a free request on CompoundList and suppliers of Combretol will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Combretol?

Suppliers quote Combretol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Combretol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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