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Cardiovascular and metabolic drugs

Compactin diol lactone

Also known as (4R,6R)-6-[2-[(1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one, (4R,6R)-4-hydroxy-6-{2-[(1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}oxan-2-one, (4R,6R)-4-hydroxy-6-(2-((1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one

CAS 58889-19-3Formula C18H26O4Molar mass 306.40 g/mol
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Compactin diol lactone chemical structure, C18H26O4, CAS 58889-19-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
58889-19-3
Formula
C18H26O4
Molar mass
306.40 g/mol
HS code
293220
Category
Cardiovascular and metabolic drugs

What is Compactin diol lactone?

Plain description, key identifiers and synonyms

Compactin diol lactone is a carbobicyclic compound that is ML-236C substituted by a hydroxy group at position 8S. It is a fungal metabolite isolated from Penicillium citrinum and exhibits anticholesteremic activity. It has a role as an antiatherosclerotic agent, an antimicrobial agent, an EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor, an antilipemic drug, an anticholesteremic drug and a fungal metabolite. It is a member of hexahydronaphthalenes, a polyketide, a secondary alcohol, a carbobicyclic compound and a member of 2-pyranones. It is functionally related to a ML-236C.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,6R)-6-[2-[(1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one
CAS number
58889-19-3 CAS number cross-checked
Molecular formula
C18H26O4
InChIKey
WWSNTLOVYSRDEL-DZSDEGEFSA-N
InChI
InChI=1S/C18H26O4/c1-11-5-6-12-3-2-4-16(20)18(12)15(11)8-7-14-9-13(19)10-17(21)22-14/h3,5-6,11,13-16,18-20H,2,4,7-10H2,1H3/t11-,13+,14+,15-,16-,18-/m0/s1
Canonical SMILES
CC1C=CC2=CCCC(O)C2C1CCC1CC(O)CC(=O)O1
Isomeric SMILES
C[C@H]1C=CC2=CCC[C@@H]([C@@H]2[C@H]1CC[C@@H]3C[C@H](CC(=O)O3)O)O

Synonyms

  • (4R,6R)-6-[2-[(1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one
  • (4R,6R)-4-hydroxy-6-{2-[(1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}oxan-2-one
  • (4R,6R)-4-hydroxy-6-(2-((1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one
  • (4R,6R)-4-hydroxy-6-{2-[(1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}tetrahydro-2H-pyran-2-one
  • desmethylmonacolin J
  • Antibiotic ML 236A
  • 2H-Pyran-2-one, 6-(2-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2-methyl-1-naphthalenyl)ethyl)tetrahydro-4-hydroxy-, (1S-(1-alpha(4S*,6S*),2-alpha,8-beta,8a-alpha))-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
306.40 g/molcalc.
Exact mass
306.1831 Dacalc.
LogP (octanol/water)
2.35calc.
Topological polar surface area
66.76 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.72calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCC(CCC2CC=CC3=CCCCC32)O1

O=C1CCCC(CCC2CC=CC3=CCCCC32)O1

3 rings, 19 atoms.

80 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Compactin diol lactone suppliers

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Compactin diol lactone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antiatherosclerotic agent
  • anticholesteremic drug
  • antilipemic drug
  • antimicrobial agent
  • cardiovascular drug
  • enzyme inhibitor
  • eukaryotic metabolite
  • fungal metabolite
  • metabolite
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Compactin diol lactone is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Compactin diol lactone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Compactin diol lactone, based on the data on this page

What is Compactin diol lactone?

Compactin diol lactone is a carbobicyclic compound that is ML-236C substituted by a hydroxy group at position 8S. It is a fungal metabolite isolated from Penicillium citrinum and exhibits anticholesteremic activity.

What is the CAS number of Compactin diol lactone?

The CAS registry number of Compactin diol lactone is 58889-19-3.

What is the molecular formula and weight of Compactin diol lactone?

The molecular formula of Compactin diol lactone is C18H26O4 and its molar mass is 306.40 g/mol.

What is Compactin diol lactone used for?

Known uses and roles of Compactin diol lactone include cardiovascular drugs in pharmaceuticals, antiatherosclerotic agent, anticholesteremic drug, antilipemic drug, antimicrobial agent and 6 more.

Is Compactin diol lactone hazardous?

No GHS hazard classification for Compactin diol lactone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Compactin diol lactone?

Compactin diol lactone is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Compactin diol lactone?

Post a free request on CompoundList and suppliers of Compactin diol lactone will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Compactin diol lactone?

Suppliers quote Compactin diol lactone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Compactin diol lactone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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