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Alkaloids

(+)-Corydaline

Also known as Corydaline, (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline, 2,3,9,10-tetramethoxy-13beta-methyl-13abeta-berbine

CAS 518-69-4Formula C22H27NO4Molar mass 369.46 g/mol
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(+)-Corydaline chemical structure, C22H27NO4, CAS 518-69-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
518-69-4
Formula
C22H27NO4
Molar mass
369.46 g/mol
HS code
293979
Category
Alkaloids

What is (+)-Corydaline?

Plain description, key identifiers and synonyms

Corydaline is an isoquinoline alkaloid and a member of isoquinolines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
CAS number
518-69-4 CAS number cross-checkedOther or deprecated CAS: 6018-35-5
Molecular formula
C22H27NO4
UNII
08N392L8VX, 6MUC9717YK
MDL number
MFCD00076019
InChIKey
VRSRXLJTYQVOHC-YEJXKQKISA-N
InChI
InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1
Canonical SMILES
COc1cc2c(cc1OC)C1C(C)c3ccc(OC)c(OC)c3CN1CC2
Isomeric SMILES
C[C@@H]1[C@@H]2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC

Synonyms

  • Corydaline
  • (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
  • 2,3,9,10-tetramethoxy-13beta-methyl-13abeta-berbine
  • 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13S,13ar)-
  • (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino(2,1-b)isoquinoline
  • 2,3,9,10-Tetramethoxy-13a-methyl-13ab-berbine
  • d-Corydaline
  • (+/-)-Corydaline
  • Corydaline, (+/-)-
  • Corydaline DL-form
  • (+)Corydaline
  • (13SR,13Ars)-5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo(a,g)-quinolizine
  • 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13R,13aS)-rel-
  • 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, trans-(+/-)-
  • Berbine, 2,3,9,10-tetramethoxy-13-methyl-
  • (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline
  • (+)-Corydaline, Corydalin
  • 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13S-trans)-
  • (+)- Corydaline
  • Corydaline (Standard)
  • 5-21-06-00173 (Beilstein Handbook Reference)
  • 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13S-E)-
  • ACon0_001192
  • ACon1_000349
  • 13abeta-Berbine, 2,3,9,10-tetramethoxy-13alpha-methyl-
Show all 33 synonyms
  • 13a-beta-Berbine, 2,3,9,10-tetramethoxy-13-alpha-methyl-
  • Berbine, 2,3,9,10-tetramethoxy-13beta-methyl-, (+/-)-
  • 2,3,9,10-Tetramethoxy-13-methyl-berbin
  • 7,8,13,13alpha-tetrahydrocorydaline
  • (+)-CorydalineCorydalin, (+/-)-Corydaline, d-Corydaline
  • (12bR,13S)-3,4,10,11-tetramethoxy-13-methyl-7,8,12b,13-tetrahydro-5H-6-azatetraphene
  • (13S,13aR)-2,3,9,10-Tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline
  • (13S,13ar)-5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo(a,g)-quinolizine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
369.46 g/molcalc.
Exact mass
369.194 Dacalc.
LogP (octanol/water)
3.94calc.
Topological polar surface area
40.16 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CC1c3ccccc3CCN1C2

c1ccc2c(c1)CC1c3ccccc3CCN1C2

4 rings, 18 atoms, the Tetrahydroprotoberberine ring system.

96 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(+)-Corydaline suppliers

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All 5 suppliers
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Where suppliers are based

5 suppliers in 2 countries

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(+)-Corydaline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Enzyme Inhibitors

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (+)-Corydaline is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (+)-Corydaline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (+)-Corydaline, based on the data on this page

What is (+)-Corydaline?

Corydaline is an isoquinoline alkaloid and a member of isoquinolines.

What is the CAS number of (+)-Corydaline?

The CAS registry number of (+)-Corydaline is 518-69-4. Other or deprecated CAS numbers: 6018-35-5.

What is the molecular formula and weight of (+)-Corydaline?

The molecular formula of (+)-Corydaline is C22H27NO4 and its molar mass is 369.46 g/mol.

What is (+)-Corydaline used for?

Known uses and roles of (+)-Corydaline include biochemical and pharmacological tools in research and laboratory and enzyme inhibitors.

Is (+)-Corydaline hazardous?

No GHS hazard classification for (+)-Corydaline is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (+)-Corydaline?

(+)-Corydaline is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (+)-Corydaline?

CompoundList lists 5 suppliers of (+)-Corydaline in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (+)-Corydaline?

Suppliers quote (+)-Corydaline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (+)-Corydaline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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