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Murcko scaffold

Tetrahydroprotoberberine scaffold

97 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
18
Chemicals
97
With full pages
34
Scaffold SMILES

c1ccc2c(c1)CC1c3ccccc3CCN1C2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Tetrahydroprotoberberine page
Murcko scaffold c1ccc2c(c1)CC1c3ccccc3CCN1C2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 97 chemicals

3,9-Dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino(2,1-b)isoquinoline-2,10-diol chemical structure, C19H21NO4, CAS 16562-14-4
3,9-Dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino(2,1-b)isoquinoline-2,10-diol
CAS 16562-14-4C19H21NO4
Rotundine chemical structure, C21H25NO4, CAS 2934-97-6
Rotundine
CAS 2934-97-6C21H25NO4
Capauridin chemical structure, C21H25NO5, CAS 478-15-9
Capauridin
CAS 478-15-9C21H25NO5
3,9,10-Trimethoxy-6,8,13,13A-tetrahydro-5H-isoquinolino(2,1-B)isoquinolin-2-ol chemical structure, C20H23NO4, CAS 6487-33-8
3,9,10-Trimethoxy-6,8,13,13A-tetrahydro-5H-isoquinolino(2,1-B)isoquinolin-2-ol
CAS 6487-33-8C20H23NO4
5,8,13,13a-Tetrahydro-2,3,10,11-tetramethoxy-6H-dibenzo(a,g)quinolizine chemical structure, C21H25NO4, CAS 13407-95-9
5,8,13,13a-Tetrahydro-2,3,10,11-tetramethoxy-6H-dibenzo(a,g)quinolizine
CAS 13407-95-9C21H25NO4
Berbine, 2,3,9,10-tetramethoxy-, hydrochloride chemical structure, C21H26ClNO4, CAS 2506-20-9
Berbine, 2,3,9,10-tetramethoxy-, hydrochloride
CAS 2506-20-9C21H26ClNO4
Scoulerine chemical structure, C19H21NO4, CAS 605-34-5
Scoulerine
CAS 605-34-5C19H21NO4
Cyclanoline chloride chemical structure, C20H24ClNO4, CAS 17472-50-3
Cyclanoline chloride
CAS 17472-50-3C20H24ClNO4
13a-beta-Berbinium, 3,9-dihydroxy-2,10-dimethoxy-7-methyl-, chloride chemical structure, C20H24ClNO4, CAS 32410-26-7
13a-beta-Berbinium, 3,9-dihydroxy-2,10-dimethoxy-7-methyl-, chloride
CAS 32410-26-7C20H24ClNO4
Phellodendrine chloride chemical structure, C20H24ClNO4, CAS 104112-82-5
Phellodendrine chloride
CAS 104112-82-5C20H24ClNO4
(-)-Tetrahydropalmatine chemical structure, C21H25NO4, CAS 483-14-7
(-)-Tetrahydropalmatine
CAS 483-14-7C21H25NO4
(-)-Capaurine chemical structure, C21H25NO5, CAS 478-14-8
(-)-Capaurine
CAS 478-14-8C21H25NO5
(+)-Corydaline chemical structure, C22H27NO4, CAS 518-69-4
(+)-Corydaline
CAS 518-69-4C22H27NO4
Tetrahydroprotoberberine chemical structure, C17H17N, CAS 483-49-8
Tetrahydroprotoberberine
CAS 483-49-8C17H17N
Clarkeanidine chemical structure, C19H21NO4, CAS 99615-99-3
Clarkeanidine
CAS 99615-99-3C19H21NO4
Yuanhunine chemical structure, C21H25NO4, CAS 104387-15-7
Yuanhunine
CAS 104387-15-7C21H25NO4
IS 35 chemical structure, C20H23NO5, CAS 86414-28-0
IS 35
CAS 86414-28-0C20H23NO5
(-)-Corydalmine chemical structure, C20H23NO4, CAS 30413-84-4
(-)-Corydalmine
CAS 30413-84-4C20H23NO4
(13aS)-5,8,13,13a-Tetrahydro-6H-dibenzo(a,g)quinolizine chemical structure, C17H17N, CAS 131-10-2
(13aS)-5,8,13,13a-Tetrahydro-6H-dibenzo(a,g)quinolizine
CAS 131-10-2C17H17N
Spinosine chemical structure, C19H21NO4, CAS 175274-51-8
Spinosine
CAS 175274-51-8C19H21NO4
Artavenustine chemical structure, C18H19NO4, CAS 88668-27-3
Artavenustine
CAS 88668-27-3C18H19NO4
Pessoine chemical structure, C18H19NO4, CAS 88668-29-5
Pessoine
CAS 88668-29-5C18H19NO4
Tetrahydrojateorrhizine chemical structure, C20H23NO4, CAS 27313-86-6
Tetrahydrojateorrhizine
CAS 27313-86-6C20H23NO4
Govanine chemical structure, C20H23NO4, CAS 59444-66-5
Govanine
CAS 59444-66-5C20H23NO4