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Analgesics and anti-inflammatories

Crisaborole

Also known as Eucrisa, AN 2728, Staquis

CAS 906673-24-3Formula C14H10BNO3Molar mass 251.05 g/molEC 696-120-1
GHS signal word: Warning. Pictograms: Harmful or irritant 89 suppliers listed Drug substance
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Crisaborole chemical structure, C14H10BNO3, CAS 906673-24-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
906673-24-3
Formula
C14H10BNO3
Molar mass
251.05 g/mol
EC number
696-120-1
HS code
293190
Category
Analgesics and anti-inflammatories

What is Crisaborole?

Plain description, key identifiers and synonyms

Crisaborole is a member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults. It has a role as a non-steroidal anti-inflammatory drug, an antipsoriatic and a phosphodiesterase IV inhibitor. It is a nitrile, an aromatic ether and a benzoxaborole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile
CAS number
906673-24-3 CAS number cross-checkedOther or deprecated CAS: 1073669-75-6
EC number
696-120-1
Molecular formula
C14H10BNO3
UNII
Q2R47HGR7P
MDL number
MFCD17169940
InChIKey
USZAGAREISWJDP-UHFFFAOYSA-N
InChI
InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
SMILES (canonical and isomeric)
B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O

Synonyms

  • Eucrisa
  • AN 2728
  • Staquis
  • crisaborol
  • Crisaborole topical ointment 2%
  • 4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile
  • 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
  • 4-((1-Hydroxy-1,3-dihydrobenzo(c)(1,2)oxaborol-6-yl)oxy)benzonitrile
  • Benzonitrile, 4-((1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy)-
  • crisaborolum
  • 4-((1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy)benzonitrile
  • 4-((1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy)benzonitrile
  • 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
  • 5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole
  • Crisaborole (AN2728)
  • 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile
  • 4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzonitrile
  • 4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzonitrile
  • 4-[(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy]benzonitrile
  • Eucrisa (TN)
  • Crisaborole (Standard)
  • Crisaborole (USAN/INN)
  • Crisaborole(AN-2728)?
  • Crisaborole, >=98% (HPLC)
  • compound 5b
Show all 27 synonyms
  • 5-(4-cyanophenoxy)-1-hydroxy-2,1-benzoxaborole
  • 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrileAN 2728

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
251.05 g/molcalc.
Exact mass
251.0754 Dacalc.
LogP (octanol/water)
1.57calc.
Topological polar surface area
62.48 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
19calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, B1OCc2cc(Oc3ccccc3)ccc21

B1OCc2cc(Oc3ccccc3)ccc21

3 rings, 16 atoms.

31 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (13)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Crisaborole suppliers

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All 89 suppliers
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Where suppliers are based

89 suppliers in 13 countries

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Crisaborole price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • antipsoriatic
  • antirheumatic drug
  • dermatologic drug
  • enzyme inhibitor
  • non-steroidal anti-inflammatory drug
  • pharmaceutical
  • phosphodiesterase IV inhibitor

Pharmacology

Crisaborole is a Phosphodiesterase 4 Inhibitor. The mechanism of action of crisaborole is as a Phosphodiesterase 4 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Crisaborole is traded under.

HS 2931.90Indicative HS code

Organo-inorganic compounds, other than tetramethyl lead, tetraethyl lead, tributyltin compounds…

World exports in 2024
$3.97B
+5.3% vs 2023, imports $3.93B
2019 to 2024
Top exporters
  1. China28.3%
  2. United States15.6%
  3. Germany15.1%
Top importers
  1. United States14.6%
  2. China13.0%
  3. South Korea8.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Crisaborole is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Crisaborole, based on the data on this page

What is Crisaborole?

Crisaborole is a member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults.

What is the CAS number of Crisaborole?

The CAS registry number of Crisaborole is 906673-24-3. Other or deprecated CAS numbers: 1073669-75-6.

What is the molecular formula and weight of Crisaborole?

The molecular formula of Crisaborole is C14H10BNO3 and its molar mass is 251.05 g/mol.

What is Crisaborole used for?

Known uses and roles of Crisaborole include anti-inflammatories in pharmaceuticals, building blocks in research and laboratory, anti-inflammatory agent, anti-inflammatory drug, antipsoriatic and 6 more.

Is Crisaborole hazardous?

Crisaborole carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Crisaborole?

Crisaborole is usually classified under HS code 293190 (X. ORGANO-INORGANIC COMPOUNDS, HETEROCYCLIC COMPOUNDS, NUCLEIC ACIDS AND THEIR SALTS…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Crisaborole?

CompoundList lists 89 suppliers of Crisaborole in China, India, United States, Italy and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Crisaborole in India?

13 suppliers in India list Crisaborole on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Crisaborole?

Suppliers quote Crisaborole on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Crisaborole

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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