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Heterocyclic building blocks

Cyclizine

Also known as Nautazine, Ciclizina, Neo-devomit

CAS 82-92-8Formula C18H22N2Molar mass 266.39 g/molEC 201-445-5
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 18 suppliers listed
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Cyclizine chemical structure, C18H22N2, CAS 82-92-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from petroleum ether
Melting point
105.5 to 107.5
Solubility
SOL IN ALCOHOL & CHLOROFORM, SLIGHTLY SOL IN WATER
HS code
293359
Category
Heterocyclic building blocks
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Cyclizine?

Plain description, key identifiers and synonyms

Cyclizine is an N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. It has a role as a central nervous system depressant, a local anaesthetic, a H1-receptor antagonist, a cholinergic antagonist and an antiemetic.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-benzhydryl-4-methylpiperazine
CAS number
82-92-8 CAS number cross-checked
EC numbers
201-445-5, 919-673-5
Molecular formula
C18H22N2
UNII
QRW9FCR9P2
MDL number
MFCD00023293
InChIKey
UVKZSORBKUEBAZ-UHFFFAOYSA-N
InChI
InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
SMILES (canonical and isomeric)
CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

Synonyms

  • Nautazine
  • Ciclizina
  • Neo-devomit
  • 1-(Diphenylmethyl)-4-methylpiperazine
  • Compound 47-83
  • Cyclizinum
  • N-Benzhydryl-N'-methylpiperazine
  • N-Methyl-N'-benzhydrylpiperazine
  • (N-Benzhydryl)(N'-methyl)diethylenediamine
  • Wellcome prepn 47-83
  • 1-Benzhydryl-4-methylpiperazin
  • Piperazine, 1-(diphenylmethyl)-4-methyl-
  • BW 47-83
  • (+-)-1-diphenylmethyl-4-methylpiperazine
  • 5-23-01-00232 (Beilstein Handbook Reference)
  • 1-Benzhydryl-4-methylpiperazine
  • Marezine
  • Wellcome preparation 47-83
  • Wellcome prepn. 47-83
  • Cyclizine chloride
  • Cyclizine (INN)
  • 1-benzhydryl-4-methyl-piperazine
  • N-Methyl-N'-benzyhydrylpiperazine
  • 1-Diphenylmethyl-4-methylpiperazine
  • Emoquil
Show all 31 synonyms
  • Wellcome
  • Ne-devomit
  • Cyclizine Base
  • Cyclizine?
  • Emoquil (Salt/Mix)
  • Marzine (Salt/Mix)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from petroleum etherexp.
Odour
PRACTICALLY ODORLESSexp.
Melting point
105.5 to 107.5exp.
Solubility
SOL IN ALCOHOL & CHLOROFORM, SLIGHTLY SOL IN WATERexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
266.39 g/molcalc.
Exact mass
266.1783 Dacalc.
LogP (octanol/water)
3.02calc.
Topological polar surface area
6.48 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C(c2ccccc2)N2CCNCC2)cc1

c1ccc(C(c2ccccc2)N2CCNCC2)cc1

3 rings, 19 atoms, the Benzhydrylpiperazine ring system.

353 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cyclizine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 18 suppliers
18 of 18 offers
  • Siegfried Barbera S.L.
    Spain, Barbera Del Valles ManufacturerUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • Qingdao Pana-Life Biochem Co., Ltd.
    China, Qingdao ManufacturerUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • Scada
    Pakistan ManufacturerUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • Pro Test
    Poland, Warszawa ManufacturerUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • Opulent Pharma
    India ManufacturerUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • AChemBlock
    United States, HaywardUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • Acmec Biochemical
    China, ShanghaiUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • Bic Biotech
    China, NanjingUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • Chemenu. Inc.
    China, ShanghaiUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View
  • ChemShuttle
    United States, BurlingameUnclaimed profile
    CyclizineGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

18 suppliers in 7 countries

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Cyclizine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antiemetics
  • Histamine H1 Antagonists

Roles

  • H1-receptor antagonist
  • anaesthetic
  • antagonist
  • antiemetic
  • central nervous system depressant
  • central nervous system drug
  • cholinergic antagonist
  • cholinergic drug
  • histamine antagonist
  • histaminergic drug
  • local anaesthetic
  • neurotransmitter agent
  • pharmaceutical

How it is made

By action of benzhydryl chloride on n-methyl piperazine: baltzyl et al, j org chem (14) 775, 1949, us patent 2,630,435 (1953 to burroughs wellcome).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Cyclizine (INN) and its salts, Ref no: 159, Annex ref: II/159

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cyclizine is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cyclizine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cyclizine, based on the data on this page

What is Cyclizine?

Cyclizine is an N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. It has a role as a central nervous system depressant, a local anaesthetic, a H1-receptor antagonist, a cholinergic antagonist and an antiemetic.

What is the CAS number of Cyclizine?

The CAS registry number of Cyclizine is 82-92-8.

What is the molecular formula and weight of Cyclizine?

The molecular formula of Cyclizine is C18H22N2 and its molar mass is 266.39 g/mol.

What is Cyclizine used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Cyclizine hazardous?

Cyclizine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cyclizine?

Cyclizine is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cyclizine?

CompoundList lists 18 suppliers of Cyclizine in China, United States, Spain, Hong Kong and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cyclizine in India?

1 supplier in India list Cyclizine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cyclizine?

Suppliers quote Cyclizine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cyclizine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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