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Murcko scaffold

Benzhydrylpiperazine scaffold

354 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
354
With full pages
72
Scaffold SMILES

c1ccc(C(c2ccccc2)N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Benzhydrylpiperazine page
Murcko scaffold c1ccc(C(c2ccccc2)N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 354 chemicals

Cetirizine chemical structure, C21H25ClN2O3, CAS 83881-51-0
Cetirizine
CAS 83881-51-0C21H25ClN2O3
Chlorcyclizine chemical structure, C18H21ClN2, CAS 82-93-9
Chlorcyclizine
CAS 82-93-9C18H21ClN2
Hydroxyzine chemical structure, C21H27ClN2O2, CAS 68-88-2
Hydroxyzine
CAS 68-88-2C21H27ClN2O2
Cyclizine chemical structure, C18H22N2, CAS 82-92-8
Cyclizine
CAS 82-92-8C18H22N2
Norchlorcyclizine chemical structure, C17H19ClN2, CAS 303-26-4
Norchlorcyclizine
CAS 303-26-4C17H19ClN2
Etodroxizine chemical structure, C23H31ClN2O3, CAS 17692-34-1
Etodroxizine
CAS 17692-34-1C23H31ClN2O3
Efletirizine chemical structure, C21H24F2N2O3, CAS 150756-35-7
Efletirizine
CAS 150756-35-7C21H24F2N2O3
Benzhydrylpiperazine chemical structure, C17H20N2, CAS 841-77-0
Benzhydrylpiperazine
CAS 841-77-0C17H20N2
Decloxizine chemical structure, C21H28N2O2, CAS 3733-63-9
Decloxizine
CAS 3733-63-9C21H28N2O2
rel-4-((R)-((2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide chemical structure, C27H37N3O2, CAS 150428-54-9
rel-4-((R)-((2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide
CAS 150428-54-9C27H37N3O2
Snc 80 chemical structure, C28H39N3O2, CAS 156727-74-1
Snc 80
CAS 156727-74-1C28H39N3O2
1-[(2-Methylphenyl)(phenyl)methyl]piperazine chemical structure, C18H22N2, CAS 24342-61-8
1-[(2-Methylphenyl)(phenyl)methyl]piperazine
CAS 24342-61-8C18H22N2
(S)-Cetirizine chemical structure, C21H25ClN2O3, CAS 130018-76-7
(S)-Cetirizine
CAS 130018-76-7C21H25ClN2O3
1-(Bis(4-fluorophenyl)methyl)piperazine chemical structure, C17H18F2N2, CAS 27469-60-9
1-(Bis(4-fluorophenyl)methyl)piperazine
CAS 27469-60-9C17H18F2N2
N-t-Butylnorchlorcyclizine chemical structure, C21H27ClN2, CAS 24342-57-2
N-t-Butylnorchlorcyclizine
CAS 24342-57-2C21H27ClN2
1-Diphenylmethyl-4-nitrosopiperazine chemical structure, C17H19N3O, CAS 1698-25-5
1-Diphenylmethyl-4-nitrosopiperazine
CAS 1698-25-5C17H19N3O
1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine 4-oxide chemical structure, C18H21ClN2O, CAS 10457-56-4
1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine 4-oxide
CAS 10457-56-4C18H21ClN2O
Aligeron chemical structure, C20H24N2, CAS 70713-45-0
Aligeron
CAS 70713-45-0C20H24N2
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-(2-(2-ethoxyethoxy)ethyl)- chemical structure, C23H31ClN2O2, CAS 95088-24-7
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-(2-(2-ethoxyethoxy)ethyl)-
CAS 95088-24-7C23H31ClN2O2
Snc 121 chemical structure, C28H41N3O2, CAS 159860-31-8
Snc 121
CAS 159860-31-8C28H41N3O2
3-[4-(Diphenylmethyl)-3-methylpiperazin-1-yl]propan-1-ol chemical structure, C21H28N2O, CAS 7150-90-5
3-[4-(Diphenylmethyl)-3-methylpiperazin-1-yl]propan-1-ol
CAS 7150-90-5C21H28N2O
4-[4-(Diphenylmethyl)-3-methylpiperazin-1-yl]butan-1-ol chemical structure, C22H30N2O, CAS 6320-25-8
4-[4-(Diphenylmethyl)-3-methylpiperazin-1-yl]butan-1-ol
CAS 6320-25-8C22H30N2O
2-{4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}acetamide chemical structure, C19H22ClN3O, CAS 6622-72-6
2-{4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}acetamide
CAS 6622-72-6C19H22ClN3O
Piperazine, 1-[(4-chlorophenyl)(4-methoxyphenyl)methyl]- chemical structure, C18H21ClN2O, CAS 142245-64-5
Piperazine, 1-[(4-chlorophenyl)(4-methoxyphenyl)methyl]-
CAS 142245-64-5C18H21ClN2O