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Central nervous system drugs

Desipramine

Also known as Norimipramine, Desmethylimipramine, Monodemethylimipramine

CAS 50-47-5Formula C18H22N2Molar mass 266.39 g/molEC 200-040-0
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 46 suppliers listed Drug substance
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Desipramine chemical structure, C18H22N2, CAS 50-47-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
50-47-5
Formula
C18H22N2
Boiling point
172 to 174
Solubility
WHITE CRYSTALLINE POWDER, ODORLESS, BITTER TASTE, MELTS WITHIN 5 DEG RANGE BETWEEN 208-2…
HS code
293399
Category
Central nervous system drugs

What is Desipramine?

Plain description, key identifiers and synonyms

Desipramine is a dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group. It has a role as an antidepressant, an adrenergic uptake inhibitor, an alpha-adrenergic antagonist, a H1-receptor antagonist, a cholinergic antagonist, a serotonin uptake inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor and a drug allergen. It is a dibenzoazepine and a secondary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
CAS number
50-47-5 CAS number cross-checked
EC number
200-040-0
Molecular formula
C18H22N2
UNII
TG537D343B
InChIKey
HCYAFALTSJYZDH-UHFFFAOYSA-N
InChI
InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
SMILES (canonical and isomeric)
CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31

Synonyms

  • Norimipramine
  • Desmethylimipramine
  • Monodemethylimipramine
  • Desipramin
  • Demethylimipramine
  • Desimipramine
  • Dimethylimipramine
  • Dezipramine
  • Desipramina
  • Methylaminopropyliminodibenzyl
  • Imipramine, demethyl-
  • desipraminum
  • Desimpramine
  • 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
  • N-(3-Methylaminopropyl)iminobibenzyl
  • Desipramine (D4)
  • 5-(gamma-Methylaminopropyl)iminodibenzyl
  • DMI 50475
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
  • N-desmethylimipramine
  • 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-
  • Pertrofran
  • Apo Desipramine
  • Nu Desipramine
  • 3-(5,6-dihydrobenzo(b)(1)benzazepin-11-yl)-N-methylpropan-1-amine
Show all 38 synonyms
  • 5H-Dibenz[b,f]azepine, 10,11-dihydro-5-[3-(methylamino)propyl]-
  • Novo Desipramine
  • PMS Desipramine
  • 3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N-methylpropan-1-amine
  • Ratio Desipramine
  • (3-(2-azatricyclo(9.4.0.0^(3,8))pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl)propyl)(methyl)amine
  • (3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)(methyl)amine
  • (3-(2-azatricyclo(9.4.0.03,8)pentadeca-1(15),3,5,7,11,13-hexaen-2-yl)propyl)(methyl)amine
  • Norpramine
  • Sertofran
  • DMI (pharmaceutical)
  • Desipramine (INN)
  • 10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenz(b,f)azepine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Boiling point
172 to 174exp.
Solubility
WHITE CRYSTALLINE POWDER, ODORLESS, BITTER TASTE, MELTS WITHIN 5 DEG RANGE BETWEEN 208-218 °C, 1 G IN CA 4 ML CHLOROFORM, 20 ML WATER, 20 ML ALC, FREELY SOL IN METHANOL, INSOL IN ETHER /HCL/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
266.39 g/molcalc.
Exact mass
266.1783 Dacalc.
LogP (octanol/water)
3.53calc.
Topological polar surface area
15.27 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCc1ccccc1N2

c1ccc2c(c1)CCc1ccccc1N2

3 rings, 15 atoms, the Iminodibenyl ring system.

268 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H336May cause drowsiness or dizziness.
  • H370Causes damage to organs.
  • H400Very toxic to aquatic life.
Precautionary statements (16)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Desipramine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 46 suppliers
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Where suppliers are based

46 suppliers in 12 countries

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Desipramine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antidepressant.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents, Tricyclic
  • Enzyme Inhibitors

Roles

  • H1-receptor antagonist
  • adrenergic agent
  • adrenergic antagonist
  • adrenergic uptake inhibitor
  • aetiopathogenetic role
  • allergen
  • alpha-adrenergic antagonist
  • alpha-adrenergic drug
  • analgesic
  • antidepressant
  • antineoplastic agent
  • cardiovascular drug
  • central nervous system drug
  • cholinergic antagonist
  • cholinergic drug
  • drug allergen
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • serotonergic drug
  • serotonin uptake inhibitor
  • vasodilator agent

Pharmacology

Desipramine is a Tricyclic Antidepressant.

How it is made

Free base & hydrochloride: british patent 908,788 (1962 to geigy)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Desipramine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Desipramine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Desipramine, based on the data on this page

What is Desipramine?

Desipramine is a dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.

What is the CAS number of Desipramine?

The CAS registry number of Desipramine is 50-47-5.

What is the molecular formula and weight of Desipramine?

The molecular formula of Desipramine is C18H22N2 and its molar mass is 266.39 g/mol.

What is Desipramine used for?

Antidepressant. Use classes: Pharmaceuticals.

Is Desipramine hazardous?

Desipramine carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause drowsiness or dizziness, causes damage to organs. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Desipramine?

Desipramine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Desipramine?

CompoundList lists 46 suppliers of Desipramine in United States, China, Germany, Hong Kong and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Desipramine in India?

2 suppliers in India list Desipramine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Desipramine?

Suppliers quote Desipramine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Desipramine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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