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Oncology and immunology drugs

Dactinomycin

Also known as actinomycin D, Actinomycin C1, Cosmegen

CAS 50-76-0Formula C62H86N12O16Molar mass 1,255.44 g/molEC 200-063-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 53 suppliers listed Drug substance
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Dactinomycin chemical structure, C62H86N12O16, CAS 50-76-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Bright red crystalline powder
Melting point
241.7 to 242.8
Solubility
1 gram dissolves in about 8 mL of alcohol and 25 mL of water at 10 °C. 1 gram dissolves…
HS code
294190
Category
Oncology and immunology drugs
UN number
UN 2811
Illustrative photo, red pigment powder in a glass jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Dactinomycin?

Plain description, key identifiers and synonyms

Actinomycin D is an actinomycin. It has a role as a mutagen.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
CAS number
50-76-0 CAS number cross-checked
EC numbers
200-063-6, 215-757-4
Molecular formula
C62H86N12O16
UNII
1CC1JFE158
MDL number
MFCD00005033
InChIKey
RJURFGZVJUQBHK-IIXSONLDSA-N
InChI
InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
Canonical SMILES
Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O
Isomeric SMILES
C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C

Synonyms

  • actinomycin D
  • Actinomycin C1
  • Cosmegen
  • Actinomycin IV
  • Meractinomycin
  • Oncostatin K
  • Actinomycin I1
  • Actinomycin X1
  • Dactinomicina
  • Dactinomycine
  • Dactinomycinum
  • Cosmegen Lyovac
  • Lyovac-Cosmegen
  • Chounghwamycin B
  • ActD
  • Dilactone actinomycin D acid
  • Actinomycin-d
  • Actinomycin I
  • Dactinomycin D
  • Actinomycin X 1
  • Actinomycin A IV
  • Actinomycin D (Dactinomycin)
  • Lyovac cosmegen
  • Actinomycin Aiv
  • GNF-Pf-2290
Show all 35 synonyms
  • Dilactone actinomycindioic D acid
  • HBF 386
  • Actinomycindioic D acid, dilactone
  • LyovacCosmegen
  • 3H-Phenoxazine, actinomycin D deriv.
  • Lyovac, Cosmegen
  • Actinomycin-(thr-val-pro-sar-meval)
  • 2-bis(Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl))-1,9 dimethyl-4,6 3H-phenoxazinone-3
  • 1H-Pyrrolo(2,1-i)(1,4,7,10,13)oxatetraazacyclohexadecine, cyclic peptide deriv.
  • ACT D

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Bright red crystalline powderexp.
Melting point
241.7 to 242.8exp.
Solubility
1 gram dissolves in about 8 mL of alcohol and 25 mL of water at 10 °C. 1 gram dissolves in 1000 mL of water at 37 °C and about 1666 mL of ether.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,255.44 g/molcalc.
Exact mass
1,254.6285 Dacalc.
LogP (octanol/water)
0.73calc.
Topological polar surface area
360 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
18calc.
Rotatable bonds
8calc.
Heavy atoms
90calc.
Rings
7calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
10calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CNC(=O)C2CCCN2C(=O)CNC(=O)C(NC(=O)c2cc(=O)cc3oc4cccc(C(=O)NC5COC(=O)CNC(=O)CNC(=O)C6CCCN6C(=O)CNC5=O)c4nc2-3)COC(=O)CN1

O=C1CNC(=O)C2CCCN2C(=O)CNC(=O)C(NC(=O)c2cc(=O)cc3oc4cccc(C(=O)NC5COC(=O)CNC(=O)CNC(=O)C6CCCN6C(=O)CNC5=O)c4nc2-3)COC(=O)CN1

7 rings, 69 atoms.

41 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H350May cause cancer.
  • H360May damage fertility or the unborn child.
Precautionary statements (10)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dactinomycin suppliers

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All 53 suppliers
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Where suppliers are based

53 suppliers in 14 countries

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Dactinomycin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antineoplastic.

Veterinary medication:.

Pharmacological actions

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Nucleic Acid Synthesis Inhibitors
  • Protein Synthesis Inhibitors

Roles

  • aetiopathogenetic role
  • antineoplastic agent
  • genotoxin
  • mutagen
  • pharmaceutical

Pharmacology

Dactinomycin is an Actinomycin. The mechanism of action of dactinomycin is as a Nucleic Acid Synthesis Inhibitor and Protein Synthesis Inhibitor.

How it is made

Dactinomycin is elaborated during the culture of Streptomyces antibioticus. After extracting from the fermentation broth, it is purified through chromatographic and crystallization processes.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dactinomycin is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dactinomycin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dactinomycin, based on the data on this page

What is Dactinomycin?

Actinomycin D is an actinomycin. It has a role as a mutagen.

What is the CAS number of Dactinomycin?

The CAS registry number of Dactinomycin is 50-76-0.

What is the molecular formula and weight of Dactinomycin?

The molecular formula of Dactinomycin is C62H86N12O16 and its molar mass is 1,255.44 g/mol.

What is Dactinomycin used for?

Therapeutic category: Antineoplastic. Veterinary medication:.

Is Dactinomycin hazardous?

Dactinomycin carries the GHS signal word "Danger". Main hazards: fatal if swallowed, may cause cancer, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dactinomycin?

Dactinomycin is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dactinomycin?

CompoundList lists 53 suppliers of Dactinomycin in United States, China, Germany, Spain and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dactinomycin in India?

3 suppliers in India list Dactinomycin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dactinomycin?

Suppliers quote Dactinomycin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dactinomycin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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