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Peptides

Dadle

Also known as DADL, [D-Ala2, D-Leu5]-enkephalin, Leucine enkephalin-2-alanine

CAS 63631-40-3Formula C29H39N5O7Molar mass 569.66 g/mol
3 suppliers listed
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Dadle chemical structure, C29H39N5O7, CAS 63631-40-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
63631-40-3
Formula
C29H39N5O7
Molar mass
569.66 g/mol
HS code
292429
Category
Peptides

What is Dadle?

Plain description, key identifiers and synonyms

DADLE is a pentapeptide comprising of L-tyrosine, D-alanine, glycine, L-phenylalanine and D-leucine residues joined in sequence by peptide linkages. It is a synthetic delta-opioid agonist that induces hibernation, promotes survival of neurons and glial cells in the CNS, and exerts neuroprotection. It has a role as an autophagy inducer, a geroprotector, an antinociceptive agent, an opioid analgesic, a mu-opioid receptor agonist, a neuroprotective agent, a delta-opioid receptor agonist and a cardioprotective agent.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
CAS number
63631-40-3
Molecular formula
C29H39N5O7
UNII
CQK2YXW6EZ, HB4QD9GL6F
MDL number
MFCD00076411
InChIKey
ZHUJMSMQIPIPTF-IBURTVSXSA-N
InChI
InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1
Canonical SMILES
CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(C)NC(=O)C(N)Cc1ccc(O)cc1)C(=O)O
Isomeric SMILES
C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N

Synonyms

  • DADL
  • [D-Ala2, D-Leu5]-enkephalin
  • Leucine enkephalin-2-alanine
  • Enkephalin-leu,ala(2)
  • 2-Alanyl-leucine enkephalin
  • 5-Leucine-2-alanine enkephalin
  • (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
  • Enkephalin, leucine-2-alanine
  • BW 180C
  • (D-Ala2, D-Leu5)-Enkephalin
  • D-Leucine, N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-
  • (2R)-2-(((2S)-2-((2-(((2R)-2-(((2S)-2-amino-3-(4-hydroxyphenyl)propanoyl)amino)propanoyl)amino)acetyl)amino)-3-phenylpropanoyl)amino)-4-methylpentanoic acid
  • Leu Enkephalin 2 Ala
  • Leu-Enkephalin-2-Ala
  • 2 Alanyl Leucine Enkephalin
  • Leucine Enkephalin 2 Alanine
  • Leucine-2-Alanine Enkephalin
  • Enkephalin, 2-Alanyl-Leucine
  • Enkephalin, Leucine 2 Alanine
  • Enkephalin-2-Alanine, Leucine
  • 5 Leucine 2 Alanine Enkephalin
  • Enkephalin, 5-Leucine-2-Alanine
  • D-Ala(2)-D-Leu(5)-Enkephalin
  • H-TYR-D-ALA-GLY-PHE-D-LEU-OH
  • (D-Ala2,D-Leu5)-Enkephalin
Show all 37 synonyms
  • Tyr-D-Ala-Gly-Phe-D-Leu
  • [D-Ala2-D-Leu5]enkephalin
  • Enkephalin-(2-d-ala, 5-d-leu)
  • L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucine
  • (D-Ala2-d-leu5)enkephalin
  • D-Ala2, D-Leu5-Enkephalin
  • (D-Ala2,D-Leu5)enkephalin
  • H-Tyr-D-Ala-Gly-Phe-D-Leu
  • DADLE-OH
  • D-Leucine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-
  • H-Y(dA)GF(dL)-OH
  • Tyr-D-Ala-Gly-Phe-D-Leu-OH

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
569.66 g/molcalc.
Exact mass
569.2849 Dacalc.
LogP (octanol/water)
0.23calc.
Topological polar surface area
200 Ųcalc.
Hydrogen bond donors
7calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
15calc.
Heavy atoms
41calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.41calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCc1ccccc1)NCC(=O)NCC(=O)NCCc1ccccc1

O=C(CCc1ccccc1)NCC(=O)NCC(=O)NCCc1ccccc1

2 rings, 27 atoms.

297 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Dadle suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 2 countries

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Dadle price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • agonist
  • analgesic
  • antinociceptive agent
  • autophagy inducer
  • cardioprotective agent
  • delta-opioid agent
  • delta-opioid receptor agonist
  • geroprotector
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neuroprotective agent
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical
  • protective agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dadle is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dadle is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dadle, based on the data on this page

What is Dadle?

DADLE is a pentapeptide comprising of L-tyrosine, D-alanine, glycine, L-phenylalanine and D-leucine residues joined in sequence by peptide linkages. It is a synthetic delta-opioid agonist that induces hibernation, promotes survival of neurons and glial cells in the CNS, and exerts neuroprotection.

What is the CAS number of Dadle?

The CAS registry number of Dadle is 63631-40-3.

What is the molecular formula and weight of Dadle?

The molecular formula of Dadle is C29H39N5O7 and its molar mass is 569.66 g/mol.

What is Dadle used for?

Known uses and roles of Dadle include agonist, analgesic, antinociceptive agent, autophagy inducer, cardioprotective agent and 12 more.

Is Dadle hazardous?

No GHS hazard classification for Dadle is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Dadle?

Dadle is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dadle?

CompoundList lists 3 suppliers of Dadle in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Dadle?

Suppliers quote Dadle on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dadle

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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