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Deferoxamine

Also known as Desferrioxamine B, Desferrioxamine, Deferrioxamine

Deferoxamine chemical structure, C25H48N6O8, CAS 70-51-9
2D chemical structure

Key facts

What buyers check first

CAS number
70-51-9
Formula
C25H48N6O8
Molar mass
560.69 g/mol
Melting point
138 to 140
HS code
292800
Category
Aliphatic and alicyclic building blocks

What is Deferoxamine?

Plain description, key identifiers and synonyms

Desferrioxamine B is an acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N1-(5-aminopentyl)-N1-hydroxy-N4-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator. It has a role as a ferroptosis inhibitor, a siderophore, an iron chelator and a bacterial metabolite. It is a conjugate base of a desferrioxamine B(1+). It is a conjugate acid of a desferrioxamine B(3-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide
CAS number
70-51-9 CAS number cross-checked
EC number
200-738-5
Molecular formula
C25H48N6O8
UNII
J06Y7MXW4D
MDL number
MFCD00242585
InChIKey
UBQYURCVBFRUQT-UHFFFAOYSA-N
InChI
InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)
SMILES (canonical and isomeric)
CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O

Synonyms

  • Desferrioxamine B
  • Desferrioxamine
  • Deferrioxamine
  • Deferoxamine B
  • Deferrioxamine B
  • Deferoxamin
  • Deferoxaminum
  • Desferin
  • DFOM
  • Desferan
  • Desferex
  • Desferral
  • Desferrin
  • N-Benzoylferrioxamine B
  • Deferoxamina
  • DFOA
  • Ferrioxamine B, N-benzoyl-
  • Desferoxamine b
  • Dfo-b
  • N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide
  • 3,9,14,20,25-Pentaazatriacontane-2,10,13,21,24-pentone, 30-amino-3,14,25-trihydroxy-
  • 30-Amino-3,14,25-trihydroxy-3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-pentaone
  • Butanediamide, N'-(5-((4-((5-(acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)hydroxyamino)pentyl)-N-(5-aminopentyl)-N-hydroxy-
  • 1-Amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(N-acetyl hydroxylamino)-6,11,17,22-tetraazaheptaeicosane
  • N-(5-(3-((5-Aminopentyl)hydroxycarbamoyl)propionamido)pentyl)-3-((5-(N-hydroxyacetamido)pentyl)carbamoyl)propionohydroxamic acid
Show all 38 synonyms
  • N-(5-aminopentyl)-N-hydroxy-N'-[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl]butanediamide
  • Propionohydroxamic acid, N-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido)pentyl)-3-((5-(N-hydroxyacetamido)pentyl)carbamoyl)-
  • Butanediamide, N'-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-
  • Deferoximine
  • Desferioximine
  • Desferroxamine
  • N-(5-((4-(5-(acetyl(hydroxy)amino)pentylamino)-4-oxobutanoyl)-hydroxyamino)pentyl)-N'-(5-aminopentyl)-N'-hydroxybutanediamide
  • N-(5-aminopentyl)-N-hydroxy-N'-(5-(N-hydroxy-3-((5-(N-hydroxyacetamido)pentyl)carbamoyl)propanamido)pentyl)butanediamide
  • N-[5-(3-[(5-Aminopentyl)hydroxycarbamoyl]propionamido)pentyl]-3-([5-(N-hydroxyacetamido)pentyl]carbamoyl)propionohydroxamic acid
  • N-[5-{3-[(5-Aminopentyl)hydroxycarbamoyl]propionamido}pentyl]-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propionohydroxamic acid
  • Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-
  • 1-amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,22-tetraazaheptaeicosane
  • N'-(5-((4-((5-(Acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)hydroxyamino)pentyl)-N-(5-aminopentyl)-N-hydroxybutanediamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
138 to 140exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
560.69 g/molcalc.
Exact mass
560.3534 Dacalc.
LogP (octanol/water)
0.92calc.
Topological polar surface area
205.8 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
23calc.
Heavy atoms
39calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Deferoxamine suppliers

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52 suppliers in 11 countries

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Deferoxamine price

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Siderophores

Roles

  • anti-anaemic agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • bacterial metabolite
  • biophysical role
  • chelator
  • cofactor
  • ferroptosis inhibitor
  • ionophore
  • iron chelator
  • iron ionophore
  • iron(3+) chelator
  • ligand
  • membrane transport modulator
  • metabolite
  • pharmaceutical
  • prokaryotic metabolite
  • siderophore

Pharmacology

Deferoxamine is an Iron Chelator. The mechanism of action of deferoxamine is as an Iron Chelating Activity.

How it is made

Natural product forming iron complexes, isolated from streptomyces pilosus, ettlinger et al, isolation: bickel et al, helv chim acta 43, 2118 (1960). Prepn from ferrioxamine b & structure: bickel et al, helv chim acta 43, 2129 (1960).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Deferoxamine is traded under.

HS 2928.00Indicative HS code

Organic derivatives of hydrazine or of hydroxylamine

World exports in 2024
$1.38B
−9.0% vs 2023, imports $1.52B
2019 to 2024
Top exporters
  1. Switzerland * partner reported44.0%
  2. China18.4%
  3. Italy9.4%
Top importers
  1. Brazil21.8%
  2. United States12.8%
  3. Italy10.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Deferoxamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Deferoxamine, based on the data on this page

What is Deferoxamine?

Desferrioxamine B is an acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N1-(5-aminopentyl)-N1-…

What is the CAS number of Deferoxamine?

The CAS registry number of Deferoxamine is 70-51-9.

What is the molecular formula and weight of Deferoxamine?

The molecular formula of Deferoxamine is C25H48N6O8 and its molar mass is 560.69 g/mol.

What is Deferoxamine used for?

Known uses and roles of Deferoxamine include building blocks in research and laboratory, anti-anaemic agent, antimicrobial agent, antineoplastic agent, antiviral agent and 16 more.

Is Deferoxamine hazardous?

Deferoxamine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Deferoxamine?

Deferoxamine is usually classified under HS code 292800 (Organic derivatives of hydrazine or of hydroxylamine). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Deferoxamine?

CompoundList lists 52 suppliers of Deferoxamine in United States, China, United Kingdom, Spain and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Deferoxamine?

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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