Devazepide (CAS 103420-77-5): price, suppliers and safety

What is Devazepide?

Plain description, key identifiers and synonyms

Devazepide is an indolecarboxamide obtained by formal condensation of the carboxy group of indole-2-carboxylic acid with the exocyclic amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one. A cholecystokinin antagonist used for treatment of gastrointestinal disorders. It has a role as an antineoplastic agent, a gastrointestinal drug, an apoptosis inducer and a cholecystokinin antagonist. It is a 1,4-benzodiazepinone and an indolecarboxamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
CAS number: 103420-77-5 CAS number cross-checked
EC number: 683-026-0
Molecular formula: C₂₅H₂₀N₄O₂
UNII: JE6P7QY7NH
MDL number: MFCD00864500
InChIKey: NFHRQQKPEBFUJK-HSZRJFAPSA-N
InChI: InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1
Canonical SMILES: CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21
Isomeric SMILES: CN1C2=CC=CC=C2C(=N[C@@H](C1=O)NC(=O)C3=CC4=CC=CC=C4N3)C5=CC=CC=C5

Synonyms

Devazepida
Devazepidum
MK 329
(S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide
3(S)-(-)-1,3-Dihydro-3-(2-indolecarbonylamino)-1-methyl-5-phenyl-2H-(1,4)benzodiazepin-2-one
N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
1H-Indole-2-carboxamide, N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, (S)-
N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-1H-indole-2-carboxamide
N-(1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl)-1H-indole-2-carboxamide
N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
(S)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-indole-2-carboxamide
Devacade
Devazepide (Standard)
Devazepide (USAN/INN)
CCK antagonist synthetic 17
CCK antagonist synthetic 18
1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide
PDSP1_000936
PDSP2_000922
Devazepide, >=98% (HPLC), powder
(R)-1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide: 0.1C4H10O
(S)-1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide
(Z)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-indole-2-carboxamide
1H-Indole-2-carboxylic acid ((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide
1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide (L-364,718 ((S)-devazepide)

Show all 30 synonyms

1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide (MK-329, L-364,718)
1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide(Devazepide or (R) L364718)
1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide(devazepide)
1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide(L-364718)
1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide: 0.1C4H10O. 0.15CH2Cl2

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	408.46 g/molcalc.
Exact mass	408.1586 Dacalc.
LogP (octanol/water)	3.74calc.
Topological polar surface area	77.56 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	3calc.
Rotatable bonds	3calc.
Heavy atoms	31calc.
Rings	5calc.
Aromatic rings	4calc.
Fraction sp3 carbons	0.08calc.
Formal charge	0calc.
Stereocentres	1calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1

5 rings, 30 atoms.

35 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Danger

Acute toxicity (severe)

Hazard statements

H300Fatal if swallowed.

Precautionary statements (7)

P264Wash skin thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301 + P316If swallowed: Get emergency medical help immediately.
P321Specific treatment (see supplemental first aid instructions on the label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Devazepide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 9 suppliers

Verified only9 of 9 offers

AHH Chemical co.,ltd
China, ChangzhouUnclaimed profile
DevazepideGrade, purity and minimum order on request
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BioCrick
China, ChengduUnclaimed profile
DevazepideGrade, purity and minimum order on request
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Biosynce Pharmatech
China, ChengduUnclaimed profile
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Combi-Blocks, Inc.
United States, San DiegoUnclaimed profile
DevazepideGrade, purity and minimum order on request
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DC Chemicals
China, PudongUnclaimed profile
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DempoChem
Netherlands, RotterdamUnclaimed profile
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Fluorochem
United Kingdom, HadfieldUnclaimed profile
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Glixx Labs, Inc
United States, HopkintonUnclaimed profile
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SynHet - Synthetic Heterocycles
Lithuania, KaunasUnclaimed profile
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 5 countries

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Devazepide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Hormones and steroids in pharmaceuticals

Pharmacological actions

Hormone Antagonists

Roles

antagonist
antineoplastic agent
apoptosis inducer
cholecystokinin antagonist
gastrointestinal drug
hormone antagonist
hormone receptor modulator
pharmaceutical
receptor modulator

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Devazepide is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024

$16.2B

−64.4% vs 2023, imports $15.4B

2019 to 2024

Top exporters

Ireland37.0%
France * partner reported15.6%
Spain11.3%

Top importers

Germany27.8%
Ireland18.9%
Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Devazepide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

N-[5-(2-Fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide chemical structure, C25H19FN4O2, CAS 103343-58-4

5-Fluoro-N-[5-(2-fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide chemical structure, C25H18F2N4O2, CAS 2624122-73-0

6-Fluoro-N-[5-(2-fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide chemical structure, C25H18F2N4O2, CAS 2624122-08-1

5,6-Difluoro-N-[5-(2-fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide chemical structure, C25H17F3N4O2, CAS 2624119-05-5

5-Chloro-N-[5-(2-fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide chemical structure, C25H18ClFN4O2, CAS 2624118-54-1

N-[5-(2-Fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-5-methyl-1H-indole-2-carboxamide chemical structure, C26H21FN4O2, CAS 2624122-04-7

N-[5-(2-Fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-6-methyl-1H-indole-2-carboxamide chemical structure, C26H21FN4O2, CAS 2624121-54-4

6-Chloro-N-[5-(2-fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide chemical structure, C25H18ClFN4O2, CAS 2624115-04-2

N-[5-(2-Fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-pyrrolo[2,3-c]pyridine-2-carboxamide chemical structure, C24H18FN5O2, CAS 2624121-81-7

4-Fluoro-N-[5-(2-fluorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide chemical structure, C25H18F2N4O2, CAS 2624116-02-3

Same formula isomers

Different compounds that share this molecular formula

All isomers

Tinodasertib chemical structure, C25H20N4O2, CAS 1464151-33-4

Tinodasertib1464151-33-4C₂₅H₂₀N₄O₂1 supplier

3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-phenylquinazolin-4-one chemical structure, C25H20N4O2, CAS 132088-35-8

3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-phenylquinazolin-4-one132088-35-8C₂₅H₂₀N₄O₂

Ssr161421 chemical structure, C25H20N4O2, CAS 477706-73-3

Ssr161421477706-73-3C₂₅H₂₀N₄O₂

N-(5-(6-Methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)-2-naphthamide chemical structure, C25H20N4O2, CAS 946217-46-5

N-(5-(6-Methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)-2-naphthamide946217-46-5C₂₅H₂₀N₄O₂

7-Methoxy-4-(pyridin-3-yl)-6-[2-(quinolin-2-yl)ethoxy]quinazoline chemical structure, C25H20N4O2, CAS 1006890-01-2

7-Methoxy-4-(pyridin-3-yl)-6-[2-(quinolin-2-yl)ethoxy]quinazoline1006890-01-2C₂₅H₂₀N₄O₂

N-Benzyl-2-(3-(5-phenyl-1,3,4-oxadiazol-2-yl)-1H-indol-1-yl)acetamide chemical structure, C25H20N4O2, CAS 1021106-30-8

N-Benzyl-2-(3-(5-phenyl-1,3,4-oxadiazol-2-yl)-1H-indol-1-yl)acetamide1021106-30-8C₂₅H₂₀N₄O₂

AMPK activator 11 chemical structure, C25H20N4O2, CAS 2948304-00-3

AMPK activator 112948304-00-3C₂₅H₂₀N₄O₂

3-Ethoxy-N-(2-naphthalen-1-ylbenzotriazol-5-yl)benzamide chemical structure, C25H20N4O2, CAS 292064-49-4

3-Ethoxy-N-(2-naphthalen-1-ylbenzotriazol-5-yl)benzamide292064-49-4C₂₅H₂₀N₄O₂

(3-Methoxyphenyl)(3-phenyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone chemical structure, C25H20N4O2, CAS 946361-38-2

(3-Methoxyphenyl)(3-phenyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone946361-38-2C₂₅H₂₀N₄O₂

6-Amino-4-(2-methoxynaphthalen-1-yl)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C25H20N4O2, CAS 371141-65-0

6-Amino-4-(2-methoxynaphthalen-1-yl)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-5-carbonitrile371141-65-0C₂₅H₂₀N₄O₂

5-(4-Methoxyphenyl)-6-(4-methylphenyl)-1-phenylpyrazolo[3,4-d]pyrimidin-4-one chemical structure, C25H20N4O2, CAS 425648-46-0

5-(4-Methoxyphenyl)-6-(4-methylphenyl)-1-phenylpyrazolo[3,4-d]pyrimidin-4-one425648-46-0C₂₅H₂₀N₄O₂

$11-(3-Methoxyphenyl)-9-phenyl-8-oxa-12,13,15,17-tetraazatetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-1(10),2(7),3,5,13,15-hexaene chemical structure, C25H20N4O2, CAS 868147-86-8$

11-(3-Methoxyphenyl)-9-phenyl-8-oxa-12,13,15,17-tetraazatetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-1(10),2(7),3,5,13,15-hexaene868147-86-8C₂₅H₂₀N₄O₂

Frequently asked questions

Quick answers about Devazepide, based on the data on this page

What is Devazepide?

Devazepide is an indolecarboxamide obtained by formal condensation of the carboxy group of indole-2-carboxylic acid with the exocyclic amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one. A cholecystokinin antagonist used for treatment of gastrointestinal disorders.

What is the CAS number of Devazepide?

The CAS registry number of Devazepide is 103420-77-5.

What is the molecular formula and weight of Devazepide?

The molecular formula of Devazepide is C25H20N4O2 and its molar mass is 408.46 g/mol.

What is Devazepide used for?

Known uses and roles of Devazepide include hormones and steroids in pharmaceuticals, antagonist, antineoplastic agent, apoptosis inducer, cholecystokinin antagonist and 6 more.

Is Devazepide hazardous?

Devazepide carries the GHS signal word "Danger". Main hazards: fatal if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Devazepide?

Devazepide is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Devazepide?

CompoundList lists 9 suppliers of Devazepide in China, United States, United Kingdom, Lithuania and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Devazepide?

Suppliers quote Devazepide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Devazepide

Devazepide

Key facts

What is Devazepide?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Devazepide suppliers

Where suppliers are based

Send one request to many suppliers

Devazepide price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Regulatory status

HS code and trade data

Global trade

Frequently asked questions

What is Devazepide?

What is the CAS number of Devazepide?

What is the molecular formula and weight of Devazepide?

What is Devazepide used for?

Is Devazepide hazardous?

What is the HS code of Devazepide?

Where can I buy Devazepide?

What is the price of Devazepide?

Guides for buyers

Get quotes for Devazepide

Key facts

What is Devazepide?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Devazepide suppliers

Where suppliers are based

Send one request to many suppliers

Devazepide price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Regulatory status

HS code and trade data

Global trade

Related chemicals

Similar structures

Same formula isomers

Frequently asked questions

What is Devazepide?

What is the CAS number of Devazepide?

What is the molecular formula and weight of Devazepide?

What is Devazepide used for?

Is Devazepide hazardous?

What is the HS code of Devazepide?

Where can I buy Devazepide?

What is the price of Devazepide?

Guides for buyers

Get quotes for Devazepide