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Screening compounds

Dihydrocodeine bitartrate

Also known as Tuscodin, dihydrocodeine hydrogen tartrate, Dihydrocodeine acid tartrate

CAS 5965-13-9Formula C22H29NO9Molar mass 451.47 g/molEC 227-747-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 3 suppliers listed
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Dihydrocodeine bitartrate chemical structure, C22H29NO9, CAS 5965-13-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
5965-13-9
Formula
C22H29NO9
Molar mass
451.47 g/mol
EC number
227-747-7
HS code
293499
Category
Screening compounds

What is Dihydrocodeine bitartrate?

Plain description, key identifiers and synonyms

Dihydrocodeine Bitartrate is a synthetic opioid analgesic. Dihydrocodeine bitartrate mimics the actions of the endogenous opioid peptides due to its agonistic effects on the opioid receptors. Stimulation of the mu receptors produces the typical narcotic effects of analgesia, miosis, euphoria, respiratory depression, sedation, physical dependence and bradycardia. Dihydrocodeine bitartrate is twice as potent as codeine and has one third of the potency of morphine. This analgesic is used for the relief of moderate to moderately severe pain.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol, (2R,3R)-2,3-dihydroxybutanedioic acid
CAS number
5965-13-9 CAS number cross-checked
EC number
227-747-7
Molecular formula
C22H29NO9
UNII
8LXS95BSA9
InChIKey
ZGSZBVAEVPSPFM-HYTSPMEMSA-N
InChI
InChI=1S/C18H23NO3.C4H6O6/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;5-1(3(7)8)2(6)4(9)10/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-,12+,13-,17-,18-;1-,2-/m01/s1
Canonical SMILES
COc1ccc2c3c1OC1C(O)CCC4C(C2)N(C)CCC341.O=C(O)C(O)C(O)C(=O)O
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](CC4)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

Synonyms

  • Tuscodin
  • dihydrocodeine hydrogen tartrate
  • Dihydrocodeine acid tartrate
  • Codeine, dihydro-, tartrate (1:1)
  • DF 118
  • dihydrocodeine tartrate
  • Dihydrocodeine bitartrate (USP)
  • Trezix component dihydrocodeine bitartrate
  • Dihydrocodeine bitartrate cii
  • Codeine, dihydro-, Tartrate(1:1)
  • Morphinan-6-alpha-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-, Tartrate(1:1)
  • Parzone
  • Paracodeine bitartrate
  • Contugesic
  • (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol, (2R,3R)-2,3-dihydroxybutanedioic acid
  • Dihydrocodeine l-tartrate
  • Dhc plus component dihydrocodeine bitartrate
  • Synalgos-dc component dihydrocodeine bitartrate
  • Synalgos-dc-a component dihydrocodeine bitartrate
  • 4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6a-ol (+)-tartrate (salt)
  • 4,5alpha-Epoxy-6alpha-hydroxy-3-methoxy-17-methylmorphinan hydrogen (R-(R*,R*))-tartrate
  • Morphinan-6-alpha-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-, tartrate (1:1)
  • Morphinan-6alpha-ol, 4,5alpha-epoxy-3-methoxy-17-methyl-, tartrate (1:1) (salt)
  • (2R,3R)-2,3-Dihydroxybutanedioic acid--3-methoxy-17-methyl-5alpha-4,5-epoxymorphinan-6alpha-ol (1/1)
  • (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol (2R,3R)-2,3-dihydroxysuccinate
Show all 27 synonyms
  • Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6.alpha.)-2,3-dihydroxybutanedioate (1:1) (salt)
  • Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
451.47 g/molcalc.
Exact mass
451.1842 Dacalc.
LogP (octanol/water)
-0.4calc.
Topological polar surface area
157 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
4calc.
Heavy atoms
32calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.64calc.
Formal charge
0calc.
Stereocentres
7calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2c3c(c1)OC1CCCC4C(C2)NCCC314

c1cc2c3c(c1)OC1CCCC4C(C2)NCCC314

5 rings, 18 atoms.

110 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H311Toxic in contact with skin.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H331Toxic if inhaled.
  • H332Harmful if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H335May cause respiratory irritation.
Precautionary statements (30)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dihydrocodeine bitartrate suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 3 countries

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Dihydrocodeine bitartrate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dihydrocodeine bitartrate is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Dihydrocodeine bitartrate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dihydrocodeine bitartrate, based on the data on this page

What is Dihydrocodeine bitartrate?

Dihydrocodeine Bitartrate is a synthetic opioid analgesic. Dihydrocodeine bitartrate mimics the actions of the endogenous opioid peptides due to its agonistic effects on the opioid receptors.

What is the CAS number of Dihydrocodeine bitartrate?

The CAS registry number of Dihydrocodeine bitartrate is 5965-13-9.

What is the molecular formula and weight of Dihydrocodeine bitartrate?

The molecular formula of Dihydrocodeine bitartrate is C22H29NO9 and its molar mass is 451.47 g/mol.

What is Dihydrocodeine bitartrate used for?

Known uses and roles of Dihydrocodeine bitartrate include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Dihydrocodeine bitartrate hazardous?

Dihydrocodeine bitartrate carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dihydrocodeine bitartrate?

Dihydrocodeine bitartrate is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dihydrocodeine bitartrate?

CompoundList lists 3 suppliers of Dihydrocodeine bitartrate in Germany, Spain and Slovakia. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Dihydrocodeine bitartrate?

Suppliers quote Dihydrocodeine bitartrate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dihydrocodeine bitartrate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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