Dimethylformamide
Also known as N,N-Dimethylformamide, Dimethyl formamide, N-Formyldimethylamine
Key facts
What buyers check first
- Appearance
- Colorless to very slightly yellow liquid
- Melting point
- -60.3 °C
- Boiling point
- 152.8 °C
- Density
- Relative density (water = 1): 0.95
- Flash point
- 67 °C
- HS code
- 292419
- Category
- Polar aprotic solvents
- UN number
- UN 2265

What is Dimethylformamide?
Plain description, key identifiers and synonyms
N,N-dimethylformamide is a member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups. It has a role as a geroprotector, a polar aprotic solvent and a hepatotoxic agent. It is a volatile organic compound and a member of formamides. It is functionally related to a formamide.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- N,N-dimethylformamide
- CAS number
- 68-12-2 CAS number cross-checked
- EC number
- 200-679-5
- Molecular formula
- C3H7NO
- UNII
- 8696NH0Y2X
- MDL number
- MFCD00003284
- InChIKey
- ZMXDDKWLCZADIW-UHFFFAOYSA-N
- InChI
- InChI=1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
- SMILES (canonical and isomeric)
- CN(C)C=O
Synonyms
- N,N-Dimethylformamide
- Dimethyl formamide
- N-Formyldimethylamine
- Formamide, N,N-dimethyl-
- Dimethylformamid
- DMFA
- N,N-Dimethyl formamide
- Formyldimethylamine
- Dimetilformamide
- Dwumetyloformamid
- Dimetylformamidu
- DMF (amide)
- N,N Dimethylformamide
- Dimethylamid kyseliny mravenci
- N,N-Dimetilformamida
- Formic acid, amide, N,N-dimethyl-
- N,N-Dimethylmethanamide
- DMF
- Dimethylforamide
- dimethyl-Formamide
- n,n-dimethyl-Formamide
- N,N- Dimethylformamide
- N,N-Dimethylformaldehyde
- N,N-Dimethylformamid
- N,N-Dimethylformamide, HPLC Grade
Show all 32 synonymsShow fewer synonyms
- n,n,dimethylformamide
- DMF, Dimethylformamide, N,N-Dimethylformamide
- N,N-Dimethylformamide, for HPLC, >=99.9%
- N, N-dimethylformamide
- N,N-Dimethylformamide, ACS reagent, >=99.8%
- N, N-dimethyl formamide
- dimethlforamide
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Colorless to very slightly yellow liquidexp.Measured value |
|---|---|
| Odour | Fishy odorexp.Measured value |
| Melting point | -60.3 °Cexp.Measured value |
| Boiling point | 152.8 °Cexp.Measured value |
| Density | Relative density (water = 1): 0.95exp.Measured value |
| Flash point | 67 °Cexp.Measured value |
| Autoignition temperature | 440 °Cexp.Measured value |
| Solubility | Miscible with water and most common organic solventsexp.Measured value |
| Vapour pressure | 3.87 mm Hg at 25 °Cexp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 73.10 g/molcalc.Computed value |
|---|---|
| Exact mass | 73.0528 Dacalc.Computed value |
| LogP (octanol/water) | -0.3calc.Computed value |
| Topological polar surface area | 20.31 Ųcalc.Computed value |
| Hydrogen bond donors | 0calc.Computed value |
| Hydrogen bond acceptors | 1calc.Computed value |
| Rotatable bonds | 1calc.Computed value |
| Heavy atoms | 5calc.Computed value |
| Rings | 0calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 0.67calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H312Harmful in contact with skin.
- H319Causes serious eye irritation.
- H332Harmful if inhaled.
- H360DMay damage the unborn child.
Precautionary statements (15)
- P203Obtain, read and follow all safety instructions before use.
- P261Avoid breathing dust, fume, gas, mist, vapours or spray.
- P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
- P271Use only outdoors or in a well-ventilated area.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P302 + P352If on skin: Wash with plenty of water.
- P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
- P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P317Get medical help.
- P318If exposed or concerned, get medical advice.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P337 + P317If eye irritation persists: Get medical help.
- P362 + P364Take off contaminated clothing. And wash it before reuse.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
- UN number
- UN 2265
- Transport hazard class
- 3
- Packing group
- III
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidDimethylformamide suppliers
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- India, MumbaiUnclaimed profileDimethylformamideGrade, purity and minimum order on requestPrice on request
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Uses and applications
What the substance is used for, by industry and function
The most important use of DMF as a solvent for polymers is in the preparation of polyacrylonitrile solutions for the manufacture of fibrous polyacrylonitrile ... In addition DMF is used as a solvent in the preparation of high quality surfaces based on polyurethanes, which are otherwise difficult to solubilize, and it is employed as a solvent for coating surfaces with polyamides.
Solvent for liquids and gases. ... Solvent for Orlon and similar polyacrylic fibers. ...
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(Used) wherever a solvent with a slow rate of evaporation is needed.
Pharmaceutical processing and acrylic fiber production, reaction and crystallizing solvent, solvent for depositing polyurethane coatings on leather and artificial leather fabrics, separation of aliphatic hydrocarbons, recovery of CO2 in flue gases, quencher and cleaner of hot-dip tinned parts, used in high voltage capacitors, industrial paint stripping applications, solvent, reagent, and catalyst in organic chemistry.
Dimethylformamide is primarily used as an industrial solvent. Dimethylformamide solutions are used to process polymer fibers, films, and surface coatings, to permit easy spinning of acrylic fibers, to produce wire enamels, and as a crystallization medium in the pharmaceutical industry.
Industrial uses: pH regulating agent, Fuel agents, Semiconductor and photovoltaic agent, Tanning agents not otherwise specified, Solvent, Intermediate, Catalyst.
Consumer uses: Cleaning agent, Solvent.
Use classes: Solvents.
Industries and functions
Roles
- aetiopathogenetic role
- aprotic solvent
- geroprotector
- hepatotoxic agent
- pharmaceutical
- polar aprotic solvent
- polar solvent
- protective agent
- solvent
Functional uses
- Binder
How it is made
The direct or one-step synthesis of DMF begins with either pure carbon monoxide or a gas stream containing carbon monoxide. This is reacted in a continuous process with N,N-dimethylamine, by using a solution of alkali alkoxide (usually sodium methoxide) in methanol as catalyst. Methyl formate is presumably formed as an intermediate. The reaction mixture passes over an external heat exchanger to remove the excess heat generated and to ensure thorough mixing of the components. The reaction is conducted between 0.5 and 11 MPa at 50 - 200 °C.
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The reaction mixture exits the reactor through a decompression chamber. In addition to N,N-dimethylformamide, the crude product contains methanol, a certain amount of unreacted N,N-dimethylamine, dissolved carbon monoxide, and residual catalyst. The addition of acid or water deactivates any catalyst present, resulting in the formation of sodium formate. Dissolved carbon monoxide, together with inert gases, escapes from the mixture during decompression, and the off-gases are removed by combustion. Preliminary distillation is followed by a second distillation in a separate column, here, dimethylformamide is separated from methanol which contains traces of N,N-dimethylamine. Further distillation results in a product of 99.9%purity.
The two-step process for the synthesis of N,N-dimethylformamide differs from direct synthesis because methyl formate is prepared separately and introduced in the form of ca. 96% pure (commercial-grade) material.
Regulatory status
Inventories, regulations and trade controls that list this substance
Europe
- EU harmonised classification (CLP Annex VI)Index no: 616-001-00-X
Health and food
- EU Cosmetics Regulation Annex II, prohibited in cosmeticsName: Dimethylformamide (N,N-Dimethylformamide), Ref no: 355, Annex ref: II/355
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Dimethylformamide is traded under.
Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other
- United States17.5%
- Germany8.8%
- India * partner reported6.7%
* Partner reported figures, a lower bound.
The HS code shown for Dimethylformamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Dimethylformamide, based on the data on this page
What is Dimethylformamide?
What is the CAS number of Dimethylformamide?
What is the molecular formula and weight of Dimethylformamide?
What is Dimethylformamide used for?
Is Dimethylformamide hazardous?
What is the HS code of Dimethylformamide?
Where can I buy Dimethylformamide?
Where can I buy Dimethylformamide in India?
What is the price of Dimethylformamide?
Guides for buyers
Practical guides that help when you source, ship or handle Dimethylformamide
- Guide, Trade and logisticsShipping dangerous goods: UN numbers, classes and packing groupsHow the UN dangerous goods system works for chemicals, from the nine classes and UN numbers to packing groups, UN packaging marks, labels, documents and segregation.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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