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Dimethylformamide chemical structure, C3H7NO, CAS 68-12-2
2D chemical structure

Key facts

What buyers check first

Appearance
Colorless to very slightly yellow liquid
Melting point
-60.3 °C
Boiling point
152.8 °C
Density
Relative density (water = 1): 0.95
Flash point
67 °C
HS code
292419
Category
Polar aprotic solvents
UN number
UN 2265
Illustrative photo, clear colourless liquid in a glass reagent bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Dimethylformamide?

Plain description, key identifiers and synonyms

N,N-dimethylformamide is a member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups. It has a role as a geroprotector, a polar aprotic solvent and a hepatotoxic agent. It is a volatile organic compound and a member of formamides. It is functionally related to a formamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,N-dimethylformamide
CAS number
68-12-2 CAS number cross-checked
EC number
200-679-5
Molecular formula
C3H7NO
UNII
8696NH0Y2X
MDL number
MFCD00003284
InChIKey
ZMXDDKWLCZADIW-UHFFFAOYSA-N
InChI
InChI=1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
SMILES (canonical and isomeric)
CN(C)C=O

Synonyms

  • N,N-Dimethylformamide
  • Dimethyl formamide
  • N-Formyldimethylamine
  • Formamide, N,N-dimethyl-
  • Dimethylformamid
  • DMFA
  • N,N-Dimethyl formamide
  • Formyldimethylamine
  • Dimetilformamide
  • Dwumetyloformamid
  • Dimetylformamidu
  • DMF (amide)
  • N,N Dimethylformamide
  • Dimethylamid kyseliny mravenci
  • N,N-Dimetilformamida
  • Formic acid, amide, N,N-dimethyl-
  • N,N-Dimethylmethanamide
  • DMF
  • Dimethylforamide
  • dimethyl-Formamide
  • n,n-dimethyl-Formamide
  • N,N- Dimethylformamide
  • N,N-Dimethylformaldehyde
  • N,N-Dimethylformamid
  • N,N-Dimethylformamide, HPLC Grade
Show all 32 synonyms
  • n,n,dimethylformamide
  • DMF, Dimethylformamide, N,N-Dimethylformamide
  • N,N-Dimethylformamide, for HPLC, >=99.9%
  • N, N-dimethylformamide
  • N,N-Dimethylformamide, ACS reagent, >=99.8%
  • N, N-dimethyl formamide
  • dimethlforamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless to very slightly yellow liquidexp.
Odour
Fishy odorexp.
Melting point
-60.3 °Cexp.
Boiling point
152.8 °Cexp.
Density
Relative density (water = 1): 0.95exp.
Flash point
67 °Cexp.
Autoignition temperature
440 °Cexp.
Solubility
Miscible with water and most common organic solventsexp.
Vapour pressure
3.87 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
73.10 g/molcalc.
Exact mass
73.0528 Dacalc.
LogP (octanol/water)
-0.3calc.
Topological polar surface area
20.31 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
1calc.
Heavy atoms
5calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
220NFPA 704 rating

Hazard statements

  • H312Harmful in contact with skin.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H360DMay damage the unborn child.
Precautionary statements (15)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2265
Transport hazard class
3
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dimethylformamide suppliers

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Dimethylformamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

The most important use of DMF as a solvent for polymers is in the preparation of polyacrylonitrile solutions for the manufacture of fibrous polyacrylonitrile ... In addition DMF is used as a solvent in the preparation of high quality surfaces based on polyurethanes, which are otherwise difficult to solubilize, and it is employed as a solvent for coating surfaces with polyamides.

Solvent for liquids and gases. ... Solvent for Orlon and similar polyacrylic fibers. ...

Read more

(Used) wherever a solvent with a slow rate of evaporation is needed.

Pharmaceutical processing and acrylic fiber production, reaction and crystallizing solvent, solvent for depositing polyurethane coatings on leather and artificial leather fabrics, separation of aliphatic hydrocarbons, recovery of CO2 in flue gases, quencher and cleaner of hot-dip tinned parts, used in high voltage capacitors, industrial paint stripping applications, solvent, reagent, and catalyst in organic chemistry.

Dimethylformamide is primarily used as an industrial solvent. Dimethylformamide solutions are used to process polymer fibers, films, and surface coatings, to permit easy spinning of acrylic fibers, to produce wire enamels, and as a crystallization medium in the pharmaceutical industry.

Industrial uses: pH regulating agent, Fuel agents, Semiconductor and photovoltaic agent, Tanning agents not otherwise specified, Solvent, Intermediate, Catalyst.

Consumer uses: Cleaning agent, Solvent.

Use classes: Solvents.

Roles

  • aetiopathogenetic role
  • aprotic solvent
  • geroprotector
  • hepatotoxic agent
  • pharmaceutical
  • polar aprotic solvent
  • polar solvent
  • protective agent
  • solvent

Functional uses

  • Binder

How it is made

The direct or one-step synthesis of DMF begins with either pure carbon monoxide or a gas stream containing carbon monoxide. This is reacted in a continuous process with N,N-dimethylamine, by using a solution of alkali alkoxide (usually sodium methoxide) in methanol as catalyst. Methyl formate is presumably formed as an intermediate. The reaction mixture passes over an external heat exchanger to remove the excess heat generated and to ensure thorough mixing of the components. The reaction is conducted between 0.5 and 11 MPa at 50 - 200 °C.

Read more

The reaction mixture exits the reactor through a decompression chamber. In addition to N,N-dimethylformamide, the crude product contains methanol, a certain amount of unreacted N,N-dimethylamine, dissolved carbon monoxide, and residual catalyst. The addition of acid or water deactivates any catalyst present, resulting in the formation of sodium formate. Dissolved carbon monoxide, together with inert gases, escapes from the mixture during decompression, and the off-gases are removed by combustion. Preliminary distillation is followed by a second distillation in a separate column, here, dimethylformamide is separated from methanol which contains traces of N,N-dimethylamine. Further distillation results in a product of 99.9%purity.

The two-step process for the synthesis of N,N-dimethylformamide differs from direct synthesis because methyl formate is prepared separately and introduced in the form of ca. 96% pure (commercial-grade) material.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 616-001-00-X

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Dimethylformamide (N,N-Dimethylformamide), Ref no: 355, Annex ref: II/355

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dimethylformamide is traded under.

HS 2924.19Indicative HS code

Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$2.38B
−1.7% vs 2023, imports $2.22B
2019 to 2024
Top exporters
  1. China34.7%
  2. Germany12.5%
  3. India * partner reported6.8%
Top importers
  1. United States17.5%
  2. Germany8.8%
  3. India * partner reported6.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dimethylformamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dimethylformamide, based on the data on this page

What is Dimethylformamide?

N,N-dimethylformamide is a member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups. It has a role as a geroprotector, a polar aprotic solvent and a hepatotoxic agent. It is a volatile organic compound and a member of formamides.

What is the CAS number of Dimethylformamide?

The CAS registry number of Dimethylformamide is 68-12-2.

What is the molecular formula and weight of Dimethylformamide?

The molecular formula of Dimethylformamide is C3H7NO and its molar mass is 73.10 g/mol.

What is Dimethylformamide used for?

The most important use of DMF as a solvent for polymers is in the preparation of polyacrylonitrile solutions for the manufacture of fibrous polyacrylonitrile ...

Is Dimethylformamide hazardous?

Dimethylformamide carries the GHS signal word "Danger". Main hazards: harmful in contact with skin, causes serious eye irritation, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dimethylformamide?

Dimethylformamide is usually classified under HS code 292419 (Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dimethylformamide?

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What is the price of Dimethylformamide?

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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