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Screening compounds

Ebvaciclib

Also known as 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-7-one, Ebvaciclib (USAN), Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)-4-piperidinyl)amino)-

CAS 2185857-97-8Formula C20H27F2N5O4SMolar mass 471.53 g/mol
2 suppliers listed
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Ebvaciclib chemical structure, C20H27F2N5O4S, CAS 2185857-97-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2185857-97-8
Formula
C20H27F2N5O4S
Molar mass
471.53 g/mol
HS code
293590
Category
Screening compounds

What is Ebvaciclib?

Plain description, key identifiers and synonyms

Ebvaciclib is an orally bioavailable, cyclin dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Upon administration, ebvaciclib selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, an induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and proliferation and are frequently overexpressed in tumor cells.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-7-one
CAS number
2185857-97-8
Molecular formula
C20H27F2N5O4S
UNII
3B512HJD65
MDL number
MFCD31807623
InChIKey
QIEKHLDZKRQLLN-FOIQADDNSA-N
InChI
InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1
Canonical SMILES
CC1(O)CCCC1n1c(=O)c(C(F)F)cc2cnc(NC3CCN(S(C)(=O)=O)CC3)nc21
Isomeric SMILES
C[C@]1(CCC[C@H]1N2C3=NC(=NC=C3C=C(C2=O)C(F)F)NC4CCN(CC4)S(=O)(=O)C)O

Synonyms

  • 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-7-one
  • Ebvaciclib (USAN)
  • Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)-4-piperidinyl)amino)-
  • 6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-methylsulfonylpiperidin-4-yl)amino)pyrido(2,3-d)pyrimidin-7-one
  • CDK Inhibitor PF-06873600
  • PF 06873600
  • 6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl) amino)pyrido(2,3-d)pyrimidin-7(8H)-one
  • 6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
  • 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
  • 6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino}pyrido(2,3-d)pyrimidin-7(8H)-one
  • 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methanesulfonylpiperidin-4-yl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one
  • 6-(Difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)piperidin-4-yl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
  • US10233188, Example 10
  • WHO 11513
  • example 10
  • PF-06873600?
  • Ebvaciclib, PF-06873600, PF 06873600, PF06873600
  • Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-
  • 6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1- (methylsulfonyl)piperidin-4-yl) amino)pyrido(2,3-d)pyrimidin-7(8H)-one
  • 6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-(1-(methylsulfonyl)piperidin-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
  • 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]-2-[(1-methylsulfonyl-4-piperidyl)amino]pyrido[2,3-d]pyrimidin-7-one
  • 6-(Difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
471.53 g/molcalc.
Exact mass
471.1752 Dacalc.
LogP (octanol/water)
2.04calc.
Topological polar surface area
117.4 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
5calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.65calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccc2cnc(NC3CCNCC3)nc2n1C1CCCC1

O=c1ccc2cnc(NC3CCNCC3)nc2n1C1CCCC1

4 rings, 23 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Ebvaciclib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers
  • ubiochem.cn
    ChinaUnclaimed profile
    EbvaciclibGrade, purity and minimum order on request
    Price on request
    View
  • Axon Medchem
    United States, RestonUnclaimed profile
    EbvaciclibGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Ebvaciclib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ebvaciclib is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ebvaciclib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ebvaciclib, based on the data on this page

What is Ebvaciclib?

Ebvaciclib is an orally bioavailable, cyclin dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Upon administration, ebvaciclib selectively targets, binds to and inhibits the activity of CDKs.

What is the CAS number of Ebvaciclib?

The CAS registry number of Ebvaciclib is 2185857-97-8.

What is the molecular formula and weight of Ebvaciclib?

The molecular formula of Ebvaciclib is C20H27F2N5O4S and its molar mass is 471.53 g/mol.

What is Ebvaciclib used for?

Known uses and roles of Ebvaciclib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Ebvaciclib hazardous?

No GHS hazard classification for Ebvaciclib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Ebvaciclib?

Ebvaciclib is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ebvaciclib?

CompoundList lists 2 suppliers of Ebvaciclib in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ebvaciclib?

Suppliers quote Ebvaciclib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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