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Central nervous system drugs

Esketamine

Also known as l-Ketamine, (S)-Ketamine, (-)-Ketamine

CAS 33643-46-8Formula C13H16ClNOMolar mass 237.73 g/molEC 811-504-2
GHS signal word: Warning. Pictograms: Harmful or irritant Prohibited, not for trade Drug substance
Why it is not for trade
Esketamine chemical structure, C13H16ClNO, CAS 33643-46-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
33643-46-8
Formula
C13H16ClNO
Molar mass
237.73 g/mol
EC number
811-504-2
HS code
292239
Category
Central nervous system drugs

What is Esketamine?

Plain description, key identifiers and synonyms

Esketamine is the S- (more active) enantiomer of ketamine. It has a role as an analgesic, an intravenous anaesthetic and a NMDA receptor antagonist. It is an enantiomer of a (R)-ketamine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
CAS number
33643-46-8 CAS number cross-checked
EC number
811-504-2
Molecular formula
C13H16ClNO
UNII
50LFG02TXD
InChIKey
YQEZLKZALYSWHR-ZDUSSCGKSA-N
InChI
InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3/t13-/m0/s1
Canonical SMILES
CNC1(c2ccccc2Cl)CCCCC1=O
Isomeric SMILES
CN[C@@]1(CCCCC1=O)C2=CC=CC=C2Cl

Synonyms

  • l-Ketamine
  • (S)-Ketamine
  • (-)-Ketamine
  • S-Ketamine
  • (S)-(-)-Ketamine
  • Ketaved
  • Keta-s
  • Ketamine, s-
  • Ketamine, (s)-
  • S-(-)-Ketamine
  • esketamina
  • (S)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone
  • Kataved
  • (2S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone
  • cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (2S)-
  • (2S)-2-(2-chlorophenyl)-2-methylaminocyclohexan-1-one
  • esketaminum
  • Ketamine S-isomer
  • (2S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
  • (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
  • Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (S)-
  • S-Ketamin
  • (S)-(+)-Ketamine
  • Esketamine (USAN/INN)
  • (+)-Esketamine
Show all 27 synonyms
  • Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (2S)- (9CI)
  • Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (-)- (8CI)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
237.73 g/molcalc.
Exact mass
237.092 Dacalc.
LogP (octanol/water)
2.9calc.
Topological polar surface area
29.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCCC1c1ccccc1

O=C1CCCCC1c1ccccc1

2 rings, 13 atoms, the 2-Phenylcyclohexanone ring system.

222 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H332Harmful if inhaled.
Precautionary statements (9)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Esketamine suppliers

Trading restrictions apply to this substance

Psychotropic substance

Esketamine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: India NDPS Act notified psychotropic substance

Our policy on controlled substances

Esketamine price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antidepressive Agents

Roles

  • NMDA receptor antagonist
  • anaesthetic
  • analgesic
  • antagonist
  • antidepressant
  • central nervous system drug
  • excitatory amino acid antagonist
  • general anaesthetic
  • intravenous anaesthetic
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • renoprotective agent

Pharmacology

Esketamine is a cyclohexanone derivative and S-enantiomer of racemic ketamine, with analgesic, anesthetic and antidepressant activities. Although the mechanism of action is not fully understood, upon administration, esketamine targets, non-competitively binds to, and blocks N-methyl D-aspartate (NMDA) receptors. This reduces pain perception, induces sedation, and produce dissociative anesthesia.

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Esketamine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: India NDPS Act notified psychotropic substance

Our policy on controlled substances

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Esketamine is traded under.

HS 2922.39Indicative HS code

Amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than…

World exports in 2024
$187M
−0.3% vs 2023, imports $159M
2019 to 2024
Top exporters
  1. China35.3%
  2. India * partner reported27.7%
  3. Germany12.7%
Top importers
  1. Germany17.3%
  2. United States13.8%
  3. India * partner reported9.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Esketamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Esketamine, based on the data on this page

What is Esketamine?

Esketamine is the S- (more active) enantiomer of ketamine. It has a role as an analgesic, an intravenous anaesthetic and a NMDA receptor antagonist. It is an enantiomer of a (R)-ketamine.

What is the CAS number of Esketamine?

The CAS registry number of Esketamine is 33643-46-8.

What is the molecular formula and weight of Esketamine?

The molecular formula of Esketamine is C13H16ClNO and its molar mass is 237.73 g/mol.

What is Esketamine used for?

Known uses and roles of Esketamine include cns agents in pharmaceuticals, nmda receptor antagonist, anaesthetic, analgesic, antagonist and 10 more.

Is Esketamine hazardous?

Esketamine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Esketamine?

Esketamine is usually classified under HS code 292239 (Amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Esketamine on CompoundList?

No. Esketamine is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Esketamine

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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