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Heterocyclic building blocks

Ethotoin

Also known as Peganone, 3-ethyl-5-phenylimidazolidine-2,4-dione, 3-Ethyl-5-phenylhydantoin

CAS 86-35-1Formula C11H12N2O2Molar mass 204.23 g/molEC 201-665-1
GHS signal word: Warning. Pictograms: Harmful or irritant 3 suppliers listed
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Ethotoin chemical structure, C11H12N2O2, CAS 86-35-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Stout prisms from water
Melting point
94 °C
Solubility
Sparingly soluble in cold water, more soluble in hot water. Freely soluble in alcohol, e…
HS code
293329
Category
Heterocyclic building blocks
Illustrative photo, closed blue fibre drums on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Ethotoin?

Plain description, key identifiers and synonyms

Ethotoin is an imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective. It has a role as an anticonvulsant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-ethyl-5-phenylimidazolidine-2,4-dione
CAS number
86-35-1 CAS number cross-checked
EC number
201-665-1
Molecular formula
C11H12N2O2
UNII
46QG38NC4U
MDL number
MFCD00072127
InChIKey
SZQIFWWUIBRPBZ-UHFFFAOYSA-N
InChI
InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15)
SMILES (canonical and isomeric)
CCN1C(=O)C(NC1=O)C2=CC=CC=C2

Synonyms

  • Peganone
  • 3-ethyl-5-phenylimidazolidine-2,4-dione
  • 3-Ethyl-5-phenylhydantoin
  • Accenon
  • Ethotoine
  • Etotoina
  • Ethotoinum
  • 3-Ethyl-5-phenylimidazolidin-2,4-dione
  • 1-Ethyl-2,5-dioxo-4-phenylimidazolidine
  • 3-Ethyl-5-phenyl-2,4-imidazolidinedione
  • Hydantoin, 3-ethyl-5-phenyl-
  • 2,4-Imidazolidinedione, 3-ethyl-5-phenyl-
  • (+-)-3-Ethyl-5-phenylhydantoin
  • 3-ethyl-5-phenyl-imidazolidine-2,4-dione
  • 1-ethyl-2-hydroxy-4-phenyl-4,5-dihydro-1H-imidazol-5-one
  • AC-695, Accenon
  • (+/-)-3-ethyl-5-phenylhydantoin
  • Pegoanone
  • Peganone (TN)
  • Accenon (TN)
  • Ethotoin (JAN/USP/INN)
  • Ethotoin (Standard)
  • (.+/-.)-Ethotoin
  • 5-24-08-00005 (Beilstein Handbook Reference)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Stout prisms from waterexp.
Melting point
94 °Cexp.
Solubility
Sparingly soluble in cold water, more soluble in hot water. Freely soluble in alcohol, ether, benzene, dilute aqueous solutions of alkali hydroxides.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
204.23 g/molcalc.
Exact mass
204.0899 Dacalc.
LogP (octanol/water)
1.3calc.
Topological polar surface area
49.41 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
15calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.27calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NC(=O)C(c2ccccc2)N1

O=C1NC(=O)C(c2ccccc2)N1

2 rings, 13 atoms, the Phenylhydantoin ring system.

426 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ethotoin suppliers

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All 3 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 3 countries

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Ethotoin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Anticonvulsant.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anticonvulsants
  • Voltage-Gated Sodium Channel Blockers

Roles

  • anticonvulsant
  • central nervous system depressant
  • central nervous system drug
  • pharmaceutical

Pharmacology

Ethotoin is an Anti-epileptic Agent. The physiologic effect of ethotoin is by means of Decreased Central Nervous System Disorganized Electrical Activity.

How it is made

Prepared by heating the potassium salt of 5-phenylhydantoin with ethyl bromide in alcohol at 100 °C in a sealed tube: Pinner, Ber 21, 2320 (1888).

Reaction of ethyl isocyanate and alpha-amino-alpha-phenylacetic acid followed by acid-catalyzed cyclodehydration.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ethotoin is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ethotoin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ethotoin, based on the data on this page

What is Ethotoin?

Ethotoin is an imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective. It has a role as an anticonvulsant.

What is the CAS number of Ethotoin?

The CAS registry number of Ethotoin is 86-35-1.

What is the molecular formula and weight of Ethotoin?

The molecular formula of Ethotoin is C11H12N2O2 and its molar mass is 204.23 g/mol.

What is Ethotoin used for?

Therapeutic category: Anticonvulsant. Use classes: Pharmaceuticals.

Is Ethotoin hazardous?

Ethotoin carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ethotoin?

Ethotoin is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ethotoin?

CompoundList lists 3 suppliers of Ethotoin in China, Ukraine and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ethotoin?

Suppliers quote Ethotoin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ethotoin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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