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Heterocyclic building blocks

Evofosfamide

Also known as TH 302, 2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine, Evofosfamida

CAS 918633-87-1Formula C9H16Br2N5O4PMolar mass 449.04 g/mol
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Evofosfamide chemical structure, C9H16Br2N5O4P, CAS 918633-87-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
918633-87-1
Formula
C9H16Br2N5O4P
Molar mass
449.04 g/mol
HS code
293329
Category
Heterocyclic building blocks

What is Evofosfamide?

Plain description, key identifiers and synonyms

Evofosfamide is a member of the class of imidazoles that is 1H-imidazole substituted by methyl, nitro, and ({bis[(2-bromoethyl)amino]phosphoryl}oxy)methyl groups at positions 1, 2 and 5, respectively. It is a hypoxia-activated prodrug that targets hypoxic regions of tumors. The drug was being evaluated for first-line treatment of advanced pancreatic adenocarcinoma and advanced soft tissue sarcoma, in combination with chemotherapy (phase 3 trial now discontinued since the drug did not meet primary endpoints). It has a role as an alkylating agent, an antineoplastic agent and a prodrug. It is a member of imidazoles, a C-nitro compound, an organobromine compound, a tertiary amino compound and a phosphorodiamidate ester.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine
CAS number
918633-87-1 CAS number cross-checked
Molecular formula
C9H16Br2N5O4P
UNII
8A9RZ3HN8W
MDL number
MFCD22420822
InChIKey
UGJWRPJDTDGERK-UHFFFAOYSA-N
InChI
InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19)
SMILES (canonical and isomeric)
CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr

Synonyms

  • TH 302
  • 2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine
  • Evofosfamida
  • Phosphorodiamidic acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
  • (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
  • (1-Methyl-2-nitro-1H-imidazole-5-yl)methyl N,N'-bis(2-bromoethyl) diamidophosphate
  • (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)diamidophosphate
  • (2-bromoethyl)({[(2-bromoethyl)amino][(1-methyl-2-nitro-1H-imidazol-5-yl)methoxy]phosphoryl})amine
  • TH302 cpd
  • evofosfamidum
  • (2-bromoethyl)((((2-bromoethyl)amino)((1-methyl-2-nitro-1H-imidazol-5-yl)methoxy)phosphoryl))amine
  • 2-bromo-N-((2-bromoethylamino)-((3-methyl-2-nitroimidazol-4-yl)methoxy)phosphoryl)ethanamine
  • HAP TH-302
  • Hypoxia-Activated Prodrug TH-302
  • n,n'-bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1h-imidazol-5-yl)methyl ester
  • TH-302, Evofosfamide, HAP-302
  • C9H16Br2N5O4P
  • compound 3b
  • Evofosfamide(TH 302)
  • Evofosfamide(TH-302)
  • Evofosfamide (TH-302)
  • Evofosfamide(TH-302)?
  • Evofosfamide (JAN/USAN/INN)
  • 2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitro-imidazol-4-yl)methoxy]phosphoryl]ethanamine
  • Phosphorodiamidic acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester.
Show all 27 synonyms
  • 1-Methyl-2-nitro-l h-imidazole-5-yl) N,N-bis(2-bromoethyl)diamidophosphate
  • 2-Bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitro-4-imidazolyl)methoxy]phosphoryl]ethanamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
449.04 g/molcalc.
Exact mass
446.9307 Dacalc.
LogP (octanol/water)
1.92calc.
Topological polar surface area
111.3 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
10calc.
Heavy atoms
21calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1c[nH]cn1

c1c[nH]cn1

1 ring, 5 atoms, the Imidazole ring system.

14,448 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Evofosfamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 2 countries

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Evofosfamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • aetiopathogenetic role
  • alkylating agent
  • antineoplastic agent
  • genotoxin
  • mutagen
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, such as those found in hypoxic tumors, the 2-nitroimidazole moiety of evofosfamide is reduced. This releases the DNA-alkylating Br-IPM moiety, which introduces intra- and inter-strand DNA crosslinks in nearby cells, the crosslinks inhibit both DNA replication and cell division, and may lead to apoptosis of cells in the tumor. The inactive form of the prodrug is stable under normoxic conditions, which may limit systemic toxicity.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Evofosfamide is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Evofosfamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Evofosfamide, based on the data on this page

What is Evofosfamide?

Evofosfamide is a member of the class of imidazoles that is 1H-imidazole substituted by methyl, nitro, and ({bis[(2-bromoethyl)amino]phosphoryl}oxy)methyl groups at positions 1, 2 and 5, respectively. It is a hypoxia-activated prodrug that targets hypoxic regions of tumors.

What is the CAS number of Evofosfamide?

The CAS registry number of Evofosfamide is 918633-87-1.

What is the molecular formula and weight of Evofosfamide?

The molecular formula of Evofosfamide is C9H16Br2N5O4P and its molar mass is 449.04 g/mol.

What is Evofosfamide used for?

Known uses and roles of Evofosfamide include building blocks in research and laboratory, aetiopathogenetic role, alkylating agent, antineoplastic agent, genotoxin and 4 more.

Is Evofosfamide hazardous?

No GHS hazard classification for Evofosfamide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Evofosfamide?

Evofosfamide is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Evofosfamide?

CompoundList lists 4 suppliers of Evofosfamide in China and Canada. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Evofosfamide?

Suppliers quote Evofosfamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Evofosfamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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