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Central nervous system drugs

Fenfluramine

Also known as Obedrex, Rotondin, Pesos

CAS 458-24-2Formula C12H16F3NMolar mass 231.26 g/molEC 207-276-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 16 suppliers listed Drug substance
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Fenfluramine chemical structure, C12H16F3N, CAS 458-24-2
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Solid
Melting point
166 °C
Boiling point
108 to 112
HS code
292149
Category
Central nervous system drugs
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Fenfluramine?

Plain description, key identifiers and synonyms

Fenfluramine is a secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension. It has a role as a serotonergic agonist, an appetite depressant and a serotonin uptake inhibitor. It is a secondary amino compound and a member of (trifluoromethyl)benzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
CAS number
458-24-2 CAS number cross-checked
EC number
207-276-3
Molecular formula
C12H16F3N
UNII
2DS058H2CF
InChIKey
DBGIVFWFUFKIQN-UHFFFAOYSA-N
InChI
InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3
SMILES (canonical and isomeric)
CCNC(C)CC1=CC(=CC=C1)C(F)(F)F

Synonyms

  • Obedrex
  • Rotondin
  • Pesos
  • DL-Fenfluramine
  • Ponderax PA
  • Fenfluramina
  • Acino
  • Fenfluraminum
  • (+-)-Fenfluramine
  • Fenfluramin
  • Phenfluramine
  • Brabafen
  • Ponderax
  • N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
  • 2-Ethylamino-1-(3-trifluoromethylphenyl)propane
  • 1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane
  • N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine
  • 3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
  • N-Ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanamine
  • N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine
  • Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-
  • Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-
  • 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane
  • N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine
  • ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine
Show all 32 synonyms
  • ethyl((1-(3-(trifluoromethyl)phenyl)propan-2-yl))amine
  • Fenfluramine, R
  • Hydrochloride, Fenfluramine
  • Fenfluramine Hydrochloride, R
  • Fenfluramine (INN)
  • Fintepla
  • DEA No. 1670

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Solidexp.
Melting point
166 °Cexp.
Boiling point
108 to 112exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
231.26 g/molcalc.
Exact mass
231.1235 Dacalc.
LogP (octanol/water)
3.25calc.
Topological polar surface area
12.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
4calc.
Heavy atoms
16calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fenfluramine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 16 suppliers
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Where suppliers are based

16 suppliers in 8 countries

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Fenfluramine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Appetite suppressant for the short-term (a few weeks) management of obesity. (Former use).

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Selective Serotonin Reuptake Inhibitors
  • Serotonin Agents

Roles

  • anti-obesity agent
  • anticonvulsant
  • antispasmodic drug
  • appetite depressant
  • appetite regulator
  • central nervous system depressant
  • central nervous system drug
  • muscle relaxant
  • neuromuscular agent
  • neurotransmitter agent
  • pharmaceutical
  • serotonergic agonist
  • serotonergic drug
  • serotonin uptake inhibitor

Functional uses

  • Pharmaceutical

Pharmacology

Fenfluramine is an amphetamine derivative and a sympathomimetic stimulant with appetite-suppressant property. Fenfluramine, which was part of the Fen-Phen anti-obesity medication, stimulates the release of serotonin from vesicular storage, and modulates serotonin transporter function. Since serotonin regulates mood and appetite, among other functions, increased serotonin level results in a feeling of fullness and loss of appetite.

How it is made

Preperation of optical isomers: US 3198834 (1965 to Sci. Union et Cie Soc. Franc. Recherche Med.)

Preperation: L.G Beregi et al., FR M1658, eidem US 3198833 (1965 to Sci. Union et Cie Soc. Franc. Recherche Med.)

Fenfluramine is prepared by reductive alkylation of norfenfluramine with acetaldehyde [18]. The nor compound is obtained by catalytic hydrogenation of the oxime made from 3-trifluoromethylphenyl acetone.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fenfluramine is traded under.

HS 2921.49Indicative HS code

Aromatic monoamines and their derivatives, salts thereof, other

World exports in 2024
$1.14B
+5.6% vs 2023, imports $1.06B
2019 to 2024
Top exporters
  1. Germany23.3%
  2. China19.4%
  3. Singapore14.6%
Top importers
  1. Belgium15.9%
  2. South Korea15.0%
  3. Germany12.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Fenfluramine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fenfluramine, based on the data on this page

What is Fenfluramine?

Fenfluramine is a secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group.

What is the CAS number of Fenfluramine?

The CAS registry number of Fenfluramine is 458-24-2.

What is the molecular formula and weight of Fenfluramine?

The molecular formula of Fenfluramine is C12H16F3N and its molar mass is 231.26 g/mol.

What is Fenfluramine used for?

Appetite suppressant for the short-term (a few weeks) management of obesity. (Former use). Use classes: Pharmaceuticals.

Is Fenfluramine hazardous?

Fenfluramine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fenfluramine?

Fenfluramine is usually classified under HS code 292149 (Aromatic monoamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fenfluramine?

CompoundList lists 16 suppliers of Fenfluramine in United States, China, Germany, United Kingdom and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Fenfluramine?

Suppliers quote Fenfluramine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fenfluramine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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