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Central nervous system drugs

Flunitrazepam

Also known as Rohypnol, Narcozep, Roipnol

CAS 1622-62-4Formula C16H12FN3O3Molar mass 313.29 g/molEC 216-597-8
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard Prohibited, not for trade
Why it is not for trade
Flunitrazepam chemical structure, C16H12FN3O3, CAS 1622-62-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1622-62-4
Formula
C16H12FN3O3
Appearance
Pale yellow needles from methylene chloride-hexane
Melting point
166 to 167
HS code
293391
Category
Central nervous system drugs

What is Flunitrazepam?

Plain description, key identifiers and synonyms

Flunitrazepam is a 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia. It has a role as an anxiolytic drug, a sedative and a GABAA receptor agonist. It is a 1,4-benzodiazepinone, a C-nitro compound and a member of monofluorobenzenes.

Flunitrazepam is a benzodiazepine seditative.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one
CAS number
1622-62-4 CAS number cross-checked
EC number
216-597-8
Molecular formula
C16H12FN3O3
UNII
620X0222FQ
InChIKey
PPTYJKAXVCCBDU-UHFFFAOYSA-N
InChI
InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3
SMILES (canonical and isomeric)
CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3F

Synonyms

  • Rohypnol
  • Narcozep
  • Roipnol
  • Primun
  • flunipam
  • Flunitrazepamum
  • Fluridrazepam
  • Silece
  • Ro 5-4200
  • 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-
  • 5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
  • Hipnosedon
  • Hypnodorm
  • 1-Methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
  • 1,3-Dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
  • 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-5-(2-fluorophenyl)-1-methyl-7-nitro-
  • 5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Rohipnol
  • Flunitrazepam Teva
  • Flunitrazepam ratiopharm
  • Flunitrazepam neuraxpharm
  • Von Ct, Flunizep
  • Fluninoc
  • [3H]flunitrazepam
Show all 35 synonyms
  • 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one
  • flunidazepam
  • Primum
  • Flunitrazepam (1.0 mg/mL in Methanol)
  • Rohypnol (TN)
  • Flunitrazepam (1.0mg/ml in Acetonitrile)
  • Flunita
  • Fluscand
  • Valsera
  • Hypnor

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Pale yellow needles from methylene chloride-hexaneexp.
Melting point
166 to 167exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
313.29 g/molcalc.
Exact mass
313.0863 Dacalc.
LogP (octanol/water)
2.55calc.
Topological polar surface area
75.81 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
23calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN=C(c2ccccc2)c2ccccc2N1

O=C1CN=C(c2ccccc2)c2ccccc2N1

3 rings, 18 atoms, the RO-05-2921 ring system.

540 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H319Causes serious eye irritation.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (11)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Flunitrazepam suppliers

Trading restrictions apply to this substance

Psychotropic substance

Flunitrazepam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)

Our policy on controlled substances

Flunitrazepam price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Flunitrazepam is a Schedule IV controlled substance.

Schedule IV Controlled Substance: (A) The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III. (B) The drug or other substance has a currently accepted medical use in treatment in the United States. (C) Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.

Anti-Anxiety Agents, GABA Modulators.

Use classes: Nervous System, Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Anti-Anxiety Agents
  • GABA Modulators

Roles

  • GABA agent
  • GABA agonist
  • GABAA receptor agonist
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • sedative
  • tranquilizing drug

How it is made

2-Amino-5-chloro-2'-fluorobenzophenone + dimethyl sulphate + chloroacetyl chloride + ammonia (methylation/dechlorination/amide formation/condensation/nitration)

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Flunitrazepam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Flunitrazepam is traded under.

HS 2933.91Exact HS code

Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…

World exports in 2024
$118M
−26.3% vs 2023, imports $94.2M
2019 to 2024
Top exporters
  1. Italy37.7%
  2. United States22.7%
  3. India * partner reported9.8%
Top importers
  1. Germany13.8%
  2. Spain10.4%
  3. United States10.2%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Flunitrazepam is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Flunitrazepam, based on the data on this page

What is Flunitrazepam?

Flunitrazepam is a 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia. It has a role as an anxiolytic drug, a sedative and a GABAA receptor agonist.

What is the CAS number of Flunitrazepam?

The CAS registry number of Flunitrazepam is 1622-62-4.

What is the molecular formula and weight of Flunitrazepam?

The molecular formula of Flunitrazepam is C16H12FN3O3 and its molar mass is 313.29 g/mol.

What is Flunitrazepam used for?

Flunitrazepam is a Schedule IV controlled substance. Schedule IV Controlled Substance: (A) The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III. (B) The drug or other substance has a currently accepted medical use in treatment in the United States.

Is Flunitrazepam hazardous?

Flunitrazepam carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes serious eye irritation, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Flunitrazepam?

Flunitrazepam is usually classified under HS code 293391 (Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Flunitrazepam on CompoundList?

No. Flunitrazepam is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Flunitrazepam

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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