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Aliphatic and alicyclic building blocks

Fotemustine

Also known as Muphoran, Mustophorane, Fotemustina

CAS 92118-27-9Formula C9H19ClN3O5PMolar mass 315.69 g/molEC 630-468-7
GHS signal word: Warning. Pictograms: Serious health hazard 8 suppliers listed
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Fotemustine chemical structure, C9H19ClN3O5P, CAS 92118-27-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
92118-27-9
Formula
C9H19ClN3O5P
Appearance
Solid
Melting point
85 °C
HS code
293159
Category
Aliphatic and alicyclic building blocks
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Fotemustine?

Plain description, key identifiers and synonyms

Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate is a member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group. It is an organochlorine compound, an organic phosphonate and a member of N-nitrosoureas.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
CAS number
92118-27-9 CAS number cross-checkedOther or deprecated CAS: 191219-77-9, 191220-84-5
EC number
630-468-7
Molecular formula
C9H19ClN3O5P
UNII
GQ7JL9P5I2, QY93P3GN94, UPB2NN83AR
MDL number
MFCD00866278
InChIKey
YAKWPXVTIGTRJH-UHFFFAOYSA-N
InChI
InChI=1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14)
SMILES (canonical and isomeric)
CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC

Synonyms

  • Muphoran
  • Mustophorane
  • Fotemustina
  • Mustoforan
  • Fotemustinum
  • Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate
  • Phosphonic acid, (1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester
  • Diethyl(1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
  • 1-(N-(2-chloroethyl)-N-nitrosoureido)ethylphosphonic acid diethyl ester
  • (1-((((2-chloroethyl)nitrosamino)-carbonyl)amino)ethyl)phosphonic acid diethyl ester
  • Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
  • 1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
  • Fotemustine, (+)-
  • Fotemustine, (-)-
  • C9H19ClN3O5P
  • diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate
  • Phosphonic acid, (1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester, (+)-
  • Phosphonic acid, (1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester, (-)-
  • (+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
  • Muphoran (TN)
  • Fotemustine (INN/BAN)
  • Fotemustine, >=98% (HPLC)
  • diethyl (1-{[N-(2-chloroethyl)-N'-oxohydrazinecarbonyl]amino}ethyl)phosphonate
  • 1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitroso-urea
  • (+/-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
Show all 26 synonyms
  • Phosphonic acid, p-(1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Solidexp.
Melting point
85 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
315.69 g/molcalc.
Exact mass
315.0751 Dacalc.
LogP (octanol/water)
2.53calc.
Topological polar surface area
97.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
9calc.
Heavy atoms
19calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.89calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H351Suspected of causing cancer.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fotemustine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 8 suppliers
8 of 8 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

8 suppliers in 3 countries

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Fotemustine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Amino acid-linked nitrosourea alkylating agent.[The Merck Index, Fourteenth Edition (2006).

Drug Category: Antineoplastic agent.

Medicine: Antineoplastic.

Pharmacological actions

  • Antineoplastic Agents

Roles

  • aetiopathogenetic role
  • alkylating agent
  • antineoplastic agent
  • genotoxin
  • mutagen
  • pharmaceutical

Pharmacology

Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fotemustine is traded under.

HS 2931.59Indicative HS code

Halogenated organo-phosphorous derivatives, other

World exports in 2024
$46.1M
+14.5% vs 2023, imports $88.5M
2022 to 2024
Top exporters
  1. China32.9%
  2. United States32.0%
  3. Germany8.4%
Top importers
  1. Brazil32.3%
  2. United States19.2%
  3. South Korea6.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Fotemustine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fotemustine, based on the data on this page

What is Fotemustine?

Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate is a member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group.

What is the CAS number of Fotemustine?

The CAS registry number of Fotemustine is 92118-27-9. Other or deprecated CAS numbers: 191219-77-9, 191220-84-5.

What is the molecular formula and weight of Fotemustine?

The molecular formula of Fotemustine is C9H19ClN3O5P and its molar mass is 315.69 g/mol.

What is Fotemustine used for?

Amino acid-linked nitrosourea alkylating agent.[The Merck Index, Fourteenth Edition (2006). Drug Category: Antineoplastic agent. Medicine: Antineoplastic.

Is Fotemustine hazardous?

Fotemustine carries the GHS signal word "Warning". Main hazards: suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fotemustine?

Fotemustine is usually classified under HS code 293159 (Halogenated organo-phosphorous derivatives, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fotemustine?

CompoundList lists 8 suppliers of Fotemustine in China, United States and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Fotemustine?

Suppliers quote Fotemustine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fotemustine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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