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Heterocyclic building blocks

Hantzsch ester

Also known as Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, Etidin, Diethone

CAS 1149-23-1Formula C13H19NO4Molar mass 253.30 g/molEC 214-561-6
GHS signal word: Warning. Pictograms: Harmful or irritant 15 suppliers listed
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Hantzsch ester chemical structure, C13H19NO4, CAS 1149-23-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1149-23-1
Formula
C13H19NO4
Molar mass
253.30 g/mol
EC number
214-561-6
HS code
293339
Category
Heterocyclic building blocks

What is Hantzsch ester?

Plain description, key identifiers and synonyms

Hantzsch ester is a chemical substance with the molecular formula C13H19NO4 and a molar mass of 253.30 g/mol. Its CAS registry number is 1149-23-1. The IUPAC name is diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS number
1149-23-1 CAS number cross-checked
EC number
214-561-6
Molecular formula
C13H19NO4
UNII
GWN6123BUG
MDL number
MFCD00005951
InChIKey
LJXTYJXBORAIHX-UHFFFAOYSA-N
InChI
InChI=1S/C13H19NO4/c1-5-17-12(15)10-7-11(13(16)18-6-2)9(4)14-8(10)3/h14H,5-7H2,1-4H3
SMILES (canonical and isomeric)
CCOC(=O)C1=C(NC(=C(C1)C(=O)OCC)C)C

Synonyms

  • Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Etidin
  • Diethone
  • Hantzsch's dihydropyridine
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-, diethyl ester
  • diludin
  • 2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine
  • 2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine
  • ethidin
  • DM-DEOC-DHP
  • Diludine
  • Ethidine
  • diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • RR 116
  • Diethyl 2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
  • 3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine
  • 1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester
  • 3,5-diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Diethyl 1,4-dihydro-2,6-dimethyl-3-5-pyridinedicarboxylate
  • Diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
  • 2,6-Dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
  • 3,5-Dicarbethoxy-2,6-dimethyl-1,4-dihydropyridine
  • 3,5-Bis(ethoxycarbonyl)-1,4-dihydro-2,6-dimethylpyridine
  • 3,5-Diethoxycarbonyl-1,4-dihydro-2,6-dimethylpyridine
  • ethyl 5-(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate
Show all 36 synonyms
  • 3, 1,4-dihydro-2,6-dimethyl-, diethyl ester
  • DivK1c_001935
  • Diethyl1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • 2,6-Dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
  • Diethyl 1,4-dihydro-3,5-pyridinecarboxylate
  • 1,4-dihydro-3,5-dicarbethoxy-2,6-dimethyl pyridine
  • Diethyl 26-dimethyl-14-dihydropyridine-35-dicarboxylate
  • 1,4-Dihydro-3,5-dicarbethoxy-2,6-dimethylpyridine
  • 2,6-Dimethyl-3,5-bis(ethoxycarbonyl)-1,4-dihydropyridine
  • 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine
  • diethyl 1,4-dihydro-2,6-dimethy-3,5 pyridinedicarboxylate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
253.30 g/molcalc.
Exact mass
253.1314 Dacalc.
LogP (octanol/water)
1.65calc.
Topological polar surface area
64.63 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
18calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.54calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CNC=CC1

C1=CNC=CC1

1 ring, 6 atoms, the 1,4-Dihydropyridine ring system.

206 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hantzsch ester suppliers

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Where suppliers are based

15 suppliers in 9 countries

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Hantzsch ester price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hantzsch ester is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hantzsch ester is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hantzsch ester, based on the data on this page

What is Hantzsch ester?

Hantzsch ester is a chemical substance with the molecular formula C13H19NO4 and a molar mass of 253.30 g/mol. Its CAS registry number is 1149-23-1. The IUPAC name is diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

What is the CAS number of Hantzsch ester?

The CAS registry number of Hantzsch ester is 1149-23-1.

What is the molecular formula and weight of Hantzsch ester?

The molecular formula of Hantzsch ester is C13H19NO4 and its molar mass is 253.30 g/mol.

What is Hantzsch ester used for?

Known uses and roles of Hantzsch ester include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Hantzsch ester hazardous?

Hantzsch ester carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hantzsch ester?

Hantzsch ester is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hantzsch ester?

CompoundList lists 15 suppliers of Hantzsch ester in China, United States, Canada, Germany and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Hantzsch ester in India?

1 supplier in India list Hantzsch ester on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Hantzsch ester?

Suppliers quote Hantzsch ester on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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