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Analgesics and anti-inflammatories

Hydrocortisone acetate

Also known as Cortisol 21-acetate, Hydrocortisone 21-acetate, Cortell

CAS 50-03-3Formula C23H32O6Molar mass 404.50 g/molEC 200-004-4
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 132 suppliers listed Drug substance
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Hydrocortisone acetate chemical structure, C23H32O6, CAS 50-03-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
50-03-3
Formula
C23H32O6
Molar mass
404.50 g/mol
EC number
200-004-4
HS code
293721
Category
Analgesics and anti-inflammatories

What is Hydrocortisone acetate?

Plain description, key identifiers and synonyms

Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
CAS number
50-03-3 CAS number cross-checkedOther or deprecated CAS: 42016-02-4
EC number
200-004-4
Molecular formula
C23H32O6
UNII
3X7931PO74
MDL number
MFCD00037714
INCI name
HYDROCORTISONE ACETATE
InChIKey
ALEXXDVDDISNDU-JZYPGELDSA-N
InChI
InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
Canonical SMILES
CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C
Isomeric SMILES
CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)O

Synonyms

  • Cortisol 21-acetate
  • Hydrocortisone 21-acetate
  • Cortell
  • Cortef acetate
  • Cortisol acetate
  • Cortifoam
  • Lanacort
  • Carmol HC
  • Dricort
  • Micort-hc
  • Hemsol-HC
  • Orabase HCA
  • U-CORT
  • 21-O-acetylcortisol
  • Cortucid
  • Hepacort Plus
  • Barquinol HC
  • Fucidin H
  • Genticin HC
  • Gppe Foam Aero
  • Gppe Ear Susp
  • Gppe Eye Crm
  • Hc45 Hydrocort
  • Hydrocortisoni acetas
  • Chloromycetin Hydrocort
Show all 39 synonyms
  • 11beta,17,21-trihydroxypregn-4-ene-3,20-dione, 21-acetate
  • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-
  • 21-(Acetyloxy)-11,17-dihydroxypregn-4-ene-3,20-dione
  • Gerigentle
  • Astonea
  • Curaseb
  • Curetech
  • Lincoln
  • Nucort
  • Roosin
  • Glint
  • Cortisil Mdx
  • Medi-first
  • ZCort

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
404.50 g/molcalc.
Exact mass
404.2199 Dacalc.
LogP (octanol/water)
2.35calc.
Topological polar surface area
100.9 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
3calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.78calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CCC3C2CC1

O=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

1,419 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hydrocortisone acetate suppliers

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All 132 suppliers
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Where suppliers are based

132 suppliers in 20 countries

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Hydrocortisone acetate price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Cosmetic ingredient, INCI name HYDROCORTISONE ACETATE(skin conditioning)

Pharmacological actions

  • Anti-Inflammatory Agents

Roles

  • anti-inflammatory agent
  • antidepressant
  • central nervous system drug
  • dermatologic drug
  • pharmaceutical
  • psychotropic drug

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Hydrocortisone Acetate is the synthetic acetate ester form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor, then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hydrocortisone acetate is traded under.

HS 2937.21Indicative HS code

Cortisone, hydrocortisone, prednisone (dehydrocortisone) and prednisolone…

World exports in 2024
$252M
−5.8% vs 2023, imports $242M
2019 to 2024
Top exporters
  1. China62.1%
  2. Italy9.6%
  3. United States9.4%
Top importers
  1. India * partner reported17.2%
  2. United States10.1%
  3. Italy8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hydrocortisone acetate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hydrocortisone acetate, based on the data on this page

What is Hydrocortisone acetate?

Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.

What is the CAS number of Hydrocortisone acetate?

The CAS registry number of Hydrocortisone acetate is 50-03-3. Other or deprecated CAS numbers: 42016-02-4.

What is the molecular formula and weight of Hydrocortisone acetate?

The molecular formula of Hydrocortisone acetate is C23H32O6 and its molar mass is 404.50 g/mol.

What is Hydrocortisone acetate used for?

Use classes: Animal Drugs.

Is Hydrocortisone acetate hazardous?

Hydrocortisone acetate carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hydrocortisone acetate?

Hydrocortisone acetate is usually classified under HS code 293721 (Cortisone, hydrocortisone, prednisone (dehydrocortisone) and prednisolone…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hydrocortisone acetate?

CompoundList lists 132 suppliers of Hydrocortisone acetate in China, United States, India, Germany and 16 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Hydrocortisone acetate in India?

18 suppliers in India list Hydrocortisone acetate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Hydrocortisone acetate?

Suppliers quote Hydrocortisone acetate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hydrocortisone acetate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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