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Alkaloids

Piperine

Also known as 1-Piperoylpiperidine, Piperin, Bioperine

CAS 94-62-2Formula C17H19NO3Molar mass 285.34 g/molEC 202-348-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 115 suppliers listed Drug substance
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Piperine chemical structure, C17H19NO3, CAS 94-62-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
94-62-2
Formula
C17H19NO3
Molar mass
285.34 g/mol
EC number
202-348-0
HS code
293979
Category
Alkaloids

What is Piperine?

Plain description, key identifiers and synonyms

Piperine is a N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. It has a role as a NF-kappaB inhibitor, a plant metabolite, a food component and a human blood serum metabolite. It is a tertiary carboxamide, a piperidine alkaloid, a member of benzodioxoles and a N-acylpiperidine. It is functionally related to an (E,E)-piperic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
CAS number
94-62-2 CAS number cross-checkedOther or deprecated CAS: 147030-08-8, 7780-20-3
EC number
202-348-0
Molecular formula
C17H19NO3
UNII
U71XL721QK
MDL number
MFCD00005839
INCI name
PIPERINE
InChIKey
MXXWOMGUGJBKIW-YPCIICBESA-N
InChI
InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
Canonical SMILES
O=C(C=CC=Cc1ccc2c(c1)OCO2)N1CCCCC1
Isomeric SMILES
C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3

Synonyms

  • 1-Piperoylpiperidine
  • Piperin
  • Bioperine
  • Piperoylpiperidine
  • (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
  • piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-
  • (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
  • N-[(E,E)-Piperoyl]piperidine
  • 1-Piperoyl-piperidine
  • Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-
  • Piperidine, 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-
  • Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)-
  • N-((E,E)-Piperoyl)piperidine
  • Piperine 1537
  • ((1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine
  • (1-(5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine
  • (E,E)-1-piperoylpiperidine
  • (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
  • AI 3-01439
  • Piperidine, 1-piperoyl-, (E,E)-
  • Piperine, >=97%
  • Piperidine, (E,E)-
  • 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine
  • N-(E,E)-piperoyl-piperidine
  • 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine
Show all 34 synonyms
  • 5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
  • Piperidine, 1-(5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)-
  • (2E,4E)-5-(1,3-Benzodioxol-5-yl)-1-(1-piperidinyl)-2,4-pentadien-1-one
  • (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidyl)penta-2,4-dien-1-one
  • 1-[(2E,4E)-5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine
  • Piperine (aliphatic)
  • 1-Piperoylpiperidine, (E,E)-
  • Piperidine, 1-piperoyl-
  • Bioperine, 1-Piperoylpiperidine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
285.34 g/molcalc.
Exact mass
285.1365 Dacalc.
LogP (octanol/water)
3calc.
Topological polar surface area
38.77 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(C=CC=Cc1ccc2c(c1)OCO2)N1CCCCC1

O=C(C=CC=Cc1ccc2c(c1)OCO2)N1CCCCC1

3 rings, 21 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Piperine suppliers

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All 115 suppliers
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Where suppliers are based

115 suppliers in 17 countries

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Piperine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name PIPERINE(skin conditioning - miscellaneous)

Pharmacological actions

  • Cytochrome P-450 Enzyme Inhibitors

Roles

  • NF-kappaB inhibitor
  • analgesic
  • animal metabolite
  • eukaryotic metabolite
  • food component
  • human blood serum metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • pharmaceutical
  • physiological role
  • plant metabolite

Functional uses

  • Flavouring and nutrient
  • Fragrance

Cosmetic functions

  • Skin conditioning - miscellaneous

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Piperine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Piperine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Piperine, based on the data on this page

What is Piperine?

Piperine is a N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. It has a role as a NF-kappaB inhibitor, a plant metabolite, a food component and a human blood serum metabolite.

What is the CAS number of Piperine?

The CAS registry number of Piperine is 94-62-2. Other or deprecated CAS numbers: 147030-08-8, 7780-20-3.

What is the molecular formula and weight of Piperine?

The molecular formula of Piperine is C17H19NO3 and its molar mass is 285.34 g/mol.

What is Piperine used for?

Known uses and roles of Piperine include skin conditioning agents in cosmetics and personal care, nf-kappab inhibitor, analgesic, animal metabolite, eukaryotic metabolite and 12 more.

Is Piperine hazardous?

Piperine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Piperine?

Piperine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Piperine?

CompoundList lists 115 suppliers of Piperine in China, United States, India, Germany and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Piperine in India?

8 suppliers in India list Piperine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Piperine?

Suppliers quote Piperine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Piperine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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