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Screening compounds

Norboldine

Also known as Laurolistine, 1,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline-2,9-diol, Laurolitsine

CAS 5890-18-6Formula C18H19NO4Molar mass 313.35 g/mol
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Norboldine chemical structure, C18H19NO4, CAS 5890-18-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
5890-18-6
Formula
C18H19NO4
Molar mass
313.35 g/mol
HS code
293399
Category
Screening compounds

What is Norboldine?

Plain description, key identifiers and synonyms

Laurolistine is an aporphine alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV-1 integrase. It has a role as a metabolite and a HIV-1 integrase inhibitor. It is an aporphine alkaloid, a member of phenols and an aromatic ether. It is functionally related to an aporphine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6aS)-1,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
CAS number
5890-18-6 CAS number cross-checkedOther or deprecated CAS: 568-39-8
Molecular formula
C18H19NO4
UNII
5MT88IS14F
InChIKey
KYVJVURXKAZJRK-LBPRGKRZSA-N
InChI
InChI=1S/C18H19NO4/c1-22-15-8-11-10(7-13(15)20)5-12-16-9(3-4-19-12)6-14(21)18(23-2)17(11)16/h6-8,12,19-21H,3-5H2,1-2H3/t12-/m0/s1
Canonical SMILES
COc1cc2c(cc1O)CC1NCCc3cc(O)c(OC)c-2c31
Isomeric SMILES
COC1=C(C=C2C[C@H]3C4=C(C2=C1)C(=C(C=C4CCN3)O)OC)O

Synonyms

  • Laurolistine
  • 1,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline-2,9-diol
  • Laurolitsine
  • (+)-Norboldine
  • (6aS)-1,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
  • Dimethoxy-1,10 dihydroxy-2,9 nor-aporphine
  • 1,10-Dimethoxy-6a-alpha-noraporphine-2,9-diol
  • 4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-
  • Norboldine hydrochloride
  • 4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-, (6as)-
  • 4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-, (6aS)-
  • [(+)-norboldine]
  • (+)-Laurolitsine
  • 6a-alpha-Noraporphine-2,9-diol, 1,10-dimethoxy-
  • Laurolitsine, (+)-
  • (S)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-4H-dibenzo[de,g]quinoline-2,9-diol
  • (S)-1,10-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
  • 4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-, (S)-
  • (9S)-4,16-dimethoxy-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2,4,6,13(17),14-hexaene-5,15-diol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
313.35 g/molcalc.
Exact mass
313.1314 Dacalc.
LogP (octanol/water)
2.52calc.
Topological polar surface area
70.95 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
23calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CC1NCCc3cccc-2c31

c1ccc2c(c1)CC1NCCc3cccc-2c31

4 rings, 17 atoms.

289 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Norboldine suppliers

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Norboldine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • HIV-1 integrase inhibitor
  • anti-HIV agent
  • anti-HIV-1 agent
  • antimicrobial agent
  • antiviral agent
  • enzyme inhibitor
  • metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Norboldine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Norboldine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Norboldine, based on the data on this page

What is Norboldine?

Laurolistine is an aporphine alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV-1 integrase. It has a role as a metabolite and a HIV-1 integrase inhibitor.

Guides for buyers

Practical guides that help when you source, ship or handle Norboldine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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