Iberdomide (CAS 1323403-33-3): price, suppliers and safety

What is Iberdomide?

Plain description, key identifiers and synonyms

Iberdomide is a modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with immunomodulating and pro-apoptotic activities. Upon administration, iberdomide specifically binds to the cereblon (CRBN) part of the ligase complex, thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3) which are transcriptional repressors in T-cells. This leads to a reduction of their protein levels, and the modulation of the immune system, including activation of T-lymphocytes. In addition, this leads to a downregulation of other proteins, including interferon regulatory factor 4 (IRF4), which plays a key role in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: (3S)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
CAS number: 1323403-33-3
Molecular formula: C₂₅H₂₇N₃O₅
UNII: 8V66F27X44
MDL number: MFCD31382133
InChIKey: IXZOHGPZAQLIBH-NRFANRHFSA-N
InChI: InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
Canonical SMILES: O=C1CCC(N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1
Isomeric SMILES: C1CC(=O)NC(=O)[C@H]1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5

Synonyms

cc-220
(S)-3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Iberdomida
CC 220
(3S)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
(3s)-3-[4-({4-[(Morpholin-4-Yl)methyl]phenyl}methoxy)-1-Oxo-1,3-Dihydro-2h-Isoindol-2-Yl]piperidine-2,6-Dione
(3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione
2,6-Piperidinedione, 3-(1,3-dihydro-4-((4-(4-morpholinylmethyl)phenyl)methoxy)-1-oxo-2H-isoindol-2-yl)-, (3S)-
iberdomidum
(S)-3-[4-[[4-(Morpholinomethyl)benzyl]oxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione
(3S)-3-(4-((4-((Morpholin-4-yl)methyl)phenyl)methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
(3S)-3-(4-((4-((morpholin-4-yl)methyl)phenyl)methoxy)-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
(3S)-3-(7-((4-(morpholin-4-ylmethyl)phenyl)methoxy)-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Iberdomide (CC220)
(S)-3-[4-(4-Morpholin-4-yl-methyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione
Zenbexus
Iberdomide?
Iberdomide (USAN/INN)
CC-220 (Compound 6)
Iberdomide(cc-220)
compound 6
CC-220, CC220, CC 220, Iberdomide
(S)-3-(4-((4-(Morpholinometnyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
(3S)-3-[4-[[4-(morpholinomethyl)phenyl]methoxy]-1-oxo-isoindolin-2-yl]piperidine-2,6-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	449.51 g/molcalc.
Exact mass	449.1951 Dacalc.
LogP (octanol/water)	1.86calc.
Topological polar surface area	88.18 Å²calc.
Hydrogen bond donors	1calc.
Hydrogen bond acceptors	6calc.
Rotatable bonds	6calc.
Heavy atoms	33calc.
Rings	5calc.
Aromatic rings	2calc.
Fraction sp3 carbons	0.4calc.
Formal charge	0calc.
Stereocentres	1calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

O=C1CCC(N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1

5 rings, 33 atoms, the 3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione ring system.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Iberdomide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers

Verified only5 of 5 offers

Sandoo Pharmaceuticals and Chemicals Co.,Ltd
China ManufacturerUnclaimed profile
IberdomideGrade, purity and minimum order on request
Price on request
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Selleck Chemicals
SpainUnclaimed profile
IberdomideGrade, purity and minimum order on request
Price on request
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Biosynce Pharmatech
China, ChengduUnclaimed profile
IberdomideGrade, purity and minimum order on request
Price on request
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BroadPharm
United States, San DiegoUnclaimed profile
IberdomideGrade, purity and minimum order on request
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Tenova Pharmaceuticals Inc
United States, San DiegoUnclaimed profile
IberdomideGrade, purity and minimum order on request
Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

5 suppliers in 3 countries

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Iberdomide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Roles

antineoplastic agent
pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Iberdomide is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024

$26.7B

+15.0% vs 2023, imports $26.3B

2019 to 2024

Top exporters

Ireland26.3%
China15.7%
Singapore10.3%

Top importers

Reported customs values in USD, not prices.Full trade data

The HS code shown for Iberdomide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Iberdomide hydrochloride chemical structure, C25H28ClN3O5, CAS 1560678-63-8

Iberdomide hydrochloride1560678-63-8C₂₅H₂₈ClN₃O₅1 supplier

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione chemical structure, C25H27N3O5, CAS 1323402-36-3

3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione1323402-36-3C₂₅H₂₇N₃O₅

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

2,6-Piperidinedione, 3-[4-[[3-chloro-4-(4-morpholinylmethyl)phenyl]methoxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- chemical structure, C25H26ClN3O5, CAS 1323402-46-5

3-[4-({4-[(4-Methylpiperazin-1-yl)methyl]phenyl}methoxy)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione chemical structure, C26H30N4O4, CAS 1323405-59-9

3-(4-((3,4-Dichlorobenzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione chemical structure, C20H16Cl2N2O4, CAS 1061605-63-7

2-(2,6-Dioxo-3-piperidinyl)-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1H-isoindole-1,3(2H)-dione chemical structure, C25H25N3O6, CAS 1323404-18-7

3-(1-Oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)-piperidine-2,6-dione chemical structure, C26H29N3O5, CAS 1323402-44-3

2,6-Piperidinedione, 3-[4-[(3-chlorophenyl)methoxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- chemical structure, C20H17ClN2O4, CAS 1323404-58-5

(R)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile chemical structure, C32H30FN5O4, CAS 2389145-03-1

4-(4-{[4-({[2-(2,6-Dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]oxy}methyl)phenyl]methyl}piperazin-1-yl)-3-fluorobenzonitrile chemical structure, C32H30FN5O4, CAS 2260745-31-9

Mezigdomide chemical structure, C32H30FN5O4, CAS 2259648-80-9

Epaldeudomide chemical structure, C25H26FN3O5, CAS 1918159-31-5

66% similar

Epaldeudomide1918159-31-5C₂₅H₂₆FN₃O₅

Same formula isomers

Different compounds that share this molecular formula

All isomers

2-Methyl-5-oxo-N-(2-pyridinyl)-4-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C25H27N3O5, CAS 361195-47-3

2-Methyl-5-oxo-N-(2-pyridinyl)-4-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide361195-47-3C₂₅H₂₇N₃O₅

N-[1-(Furan-2-ylmethylamino)-3-methyl-1-oxobutan-2-yl]-2-[(4-methoxybenzoyl)amino]benzamide chemical structure, C25H27N3O5, CAS 345237-90-3

N-[1-(Furan-2-ylmethylamino)-3-methyl-1-oxobutan-2-yl]-2-[(4-methoxybenzoyl)amino]benzamide345237-90-3C₂₅H₂₇N₃O₅

N-(2-Methoxyphenethyl)-2-(1-(2-morpholino-2-oxoethyl)-1H-indol-3-yl)-2-oxoacetamide chemical structure, C25H27N3O5, CAS 872856-99-0

N-(2-Methoxyphenethyl)-2-(1-(2-morpholino-2-oxoethyl)-1H-indol-3-yl)-2-oxoacetamide872856-99-0C₂₅H₂₇N₃O₅

1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-5-(4-isopropoxyphenyl)-4-(5-methylfuran-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C25H27N3O5, CAS 845808-35-7

1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-5-(4-isopropoxyphenyl)-4-(5-methylfuran-2-carbonyl)-1H-pyrrol-2(5H)-one845808-35-7C₂₅H₂₇N₃O₅

N-(2-(Furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)benzo[d][1,3]dioxole-5-carboxamide chemical structure, C25H27N3O5, CAS 877647-79-5

N-(2-(Furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)benzo[d][1,3]dioxole-5-carboxamide877647-79-5C₂₅H₂₇N₃O₅

N-(4-Methoxyphenethyl)-2-(1-(2-morpholino-2-oxoethyl)-1H-indol-3-yl)-2-oxoacetamide chemical structure, C25H27N3O5, CAS 872857-01-7

N-(4-Methoxyphenethyl)-2-(1-(2-morpholino-2-oxoethyl)-1H-indol-3-yl)-2-oxoacetamide872857-01-7C₂₅H₂₇N₃O₅

2-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)amino]-2-oxoethyl 4-(4-acetylphenoxy)butanoate chemical structure, C25H27N3O5, CAS 956371-09-8

2-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)amino]-2-oxoethyl 4-(4-acetylphenoxy)butanoate956371-09-8C₂₅H₂₇N₃O₅

2-((6-((4-(4-Methoxyphenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)-N-phenylacetamide chemical structure, C25H27N3O5, CAS 898440-56-7

2-((6-((4-(4-Methoxyphenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)-N-phenylacetamide898440-56-7C₂₅H₂₇N₃O₅

2-((6-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)-N-phenylacetamide chemical structure, C25H27N3O5, CAS 898416-95-0

2-((6-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)-N-phenylacetamide898416-95-0C₂₅H₂₇N₃O₅

N-(2-Methoxyphenyl)-2-({4-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-4H-pyran-3-yl}oxy)acetamide chemical structure, C25H27N3O5, CAS 898456-17-2

N-(2-Methoxyphenyl)-2-({4-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-4H-pyran-3-yl}oxy)acetamide898456-17-2C₂₅H₂₇N₃O₅

N-(3-Methoxyphenyl)-2-((4-oxo-6-((4-phenylpiperazin-1-yl)methyl)-4H-pyran-3-yl)oxy)acetamide chemical structure, C25H27N3O5, CAS 898456-20-7

N-(3-Methoxyphenyl)-2-((4-oxo-6-((4-phenylpiperazin-1-yl)methyl)-4H-pyran-3-yl)oxy)acetamide898456-20-7C₂₅H₂₇N₃O₅

N-(4-Methoxyphenyl)-2-((4-oxo-6-((4-phenylpiperazin-1-yl)methyl)-4H-pyran-3-yl)oxy)acetamide chemical structure, C25H27N3O5, CAS 898440-89-6

N-(4-Methoxyphenyl)-2-((4-oxo-6-((4-phenylpiperazin-1-yl)methyl)-4H-pyran-3-yl)oxy)acetamide898440-89-6C₂₅H₂₇N₃O₅

Frequently asked questions

Quick answers about Iberdomide, based on the data on this page

What is Iberdomide?

Iberdomide is a modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with immunomodulating and pro-apoptotic activities.

What is the CAS number of Iberdomide?

The CAS registry number of Iberdomide is 1323403-33-3.

What is the molecular formula and weight of Iberdomide?

The molecular formula of Iberdomide is C25H27N3O5 and its molar mass is 449.51 g/mol.

What is Iberdomide used for?

Known uses and roles of Iberdomide include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Iberdomide hazardous?

No GHS hazard classification for Iberdomide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Iberdomide?

Iberdomide is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Iberdomide?

CompoundList lists 5 suppliers of Iberdomide in China, United States and Spain. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Iberdomide?

Suppliers quote Iberdomide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Iberdomide

Iberdomide

Key facts

What is Iberdomide?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Iberdomide suppliers

Where suppliers are based

Send one request to many suppliers

Iberdomide price

Uses and applications

Industries and functions

Roles

Regulatory status

HS code and trade data

Global trade

Frequently asked questions

What is Iberdomide?

What is the CAS number of Iberdomide?

What is the molecular formula and weight of Iberdomide?

What is Iberdomide used for?

Is Iberdomide hazardous?

What is the HS code of Iberdomide?

Where can I buy Iberdomide?

What is the price of Iberdomide?

Guides for buyers

Get quotes for Iberdomide

Key facts

What is Iberdomide?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Iberdomide suppliers

Where suppliers are based

Send one request to many suppliers

Iberdomide price

Uses and applications

Industries and functions

Roles

Regulatory status

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Frequently asked questions

What is Iberdomide?

What is the CAS number of Iberdomide?

What is the molecular formula and weight of Iberdomide?

What is Iberdomide used for?

Is Iberdomide hazardous?

What is the HS code of Iberdomide?

Where can I buy Iberdomide?

What is the price of Iberdomide?

Guides for buyers

Get quotes for Iberdomide