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Screening compounds

Mezigdomide

Also known as 4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile, compound 4, compound 4 (PMID: 32130004)

CAS 2259648-80-9Formula C32H30FN5O4Molar mass 567.62 g/mol
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Mezigdomide chemical structure, C32H30FN5O4, CAS 2259648-80-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2259648-80-9
Formula
C32H30FN5O4
Molar mass
567.62 g/mol
HS code
293359
Category
Screening compounds

What is Mezigdomide?

Plain description, key identifiers and synonyms

Mezigdomide is a modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. Upon administration, mezigdomide specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, some of which are transcriptional repressors in T-cells. This leads to modulation of the immune system, including activation of T-lymphocytes, and downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the CRL4-CRBN E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile
CAS number
2259648-80-9
Molecular formula
C32H30FN5O4
UNII
LA88IH4O02
MDL number
MFCD32263041
InChIKey
YTINZZFBHWSAGL-NDEPHWFRSA-N
InChI
InChI=1S/C32H30FN5O4/c33-26-16-23(17-34)8-9-27(26)37-14-12-36(13-15-37)18-21-4-6-22(7-5-21)20-42-29-3-1-2-24-25(29)19-38(32(24)41)28-10-11-30(39)35-31(28)40/h1-9,16,28H,10-15,18-20H2,(H,35,39,40)/t28-/m0/s1
Canonical SMILES
N#Cc1ccc(N2CCN(Cc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)c(F)c1
Isomeric SMILES
C1CC(=O)NC(=O)[C@H]1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCN(CC5)C6=C(C=C(C=C6)C#N)F

Synonyms

  • 4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile
  • compound 4
  • compound 4 (PMID: 32130004)
  • 4-[4-({4-[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}oxy)methyl]phenyl}methyl)piperazin-1-yl]-3-fluorobenzonitrile
  • Benzonitrile, 4-(4-((4-(((2-((3S)-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl)oxy)methyl)phenyl)methyl)-1-piperazinyl)-3-fluoro-
  • 4-(4-((4-(((2-((3S)-2,6-Dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl)oxy)methyl)phenyl)methyl)piperazin-1-yl)-3-fluorobenzonitrile
  • 4-(4-((4-((2-((3S)-2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl)oxymethyl)phenyl)methyl)piperazin-1-yl)-3-fluorobenzonitrile
  • CELMoD CC-92480
  • Cereblon Modulator CC-92480
  • BMS 986348
  • CC 92480
  • Cereblon E3 Ligase Modulation Drug CC-92480
  • Cereblon E3 Ubiquitin Ligase Modulating Agent CC-92480
  • (S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile
  • WHO 11455
  • (83S)-12-fluoro-71,82,86-trioxo-71,73-dihydro-6-oxa-7(4,2)-isoindola-2(1,4)-piperazina-8(3)-piperidina-1(1),4(1,4)-dibenzenaoctaphane-14-carbonitrile
  • Benzonitrile, 4-(4-((4-(((2-((3S)-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1Hisoindol-4-yl)oxy)methyl)phenyl)methyl)-1-piperazinyl)-3-fluoro-
  • Mezigdomide (cc-92480)
  • QFC
  • Mezigdomide (JAN/USAN)
  • CPD. 3(CC-92480)
  • (S)-4-[4-[4-[[[2-(2,6-Dioxo-3-piperidyl)-1-oxo-4-isoindolinyl]oxy]methyl]benzyl]-1-piperazinyl]-3-fluorobenzonitrile
  • 4-(4-((4-(((2-((3S)-2,6-Dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4- yl)oxy)methyl)phenyl)methyl)piperazin-1-yl)-3-fluorobenzonitrile
  • 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy] methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-Benzonitrile
  • 4-[4-[[4-[[2-[(3S)-2,6-dioxo-3-piperidyl]-1-oxo-isoindolin-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluoro-benzonitrile

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
567.62 g/molcalc.
Exact mass
567.2282 Dacalc.
LogP (octanol/water)
3.36calc.
Topological polar surface area
106 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
7calc.
Heavy atoms
42calc.
Rings
6calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.31calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccccc6)CC5)cc4)cccc3C2=O)C(=O)N1

O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccccc6)CC5)cc4)cccc3C2=O)C(=O)N1

6 rings, 39 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Mezigdomide suppliers

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Mezigdomide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical
  • protective agent
  • renoprotective agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mezigdomide is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Mezigdomide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mezigdomide, based on the data on this page

What is Mezigdomide?

Mezigdomide is a modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities.

What is the CAS number of Mezigdomide?

The CAS registry number of Mezigdomide is 2259648-80-9.

What is the molecular formula and weight of Mezigdomide?

The molecular formula of Mezigdomide is C32H30FN5O4 and its molar mass is 567.62 g/mol.

What is Mezigdomide used for?

Known uses and roles of Mezigdomide include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, pharmaceutical, protective agent and 1 more.

Is Mezigdomide hazardous?

No GHS hazard classification for Mezigdomide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mezigdomide?

Mezigdomide is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mezigdomide?

CompoundList lists 1 supplier of Mezigdomide in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Mezigdomide?

Suppliers quote Mezigdomide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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