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Oncology and immunology drugs

Lapatinib

Also known as GW 572016, GSK 572016, n-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine

CAS 231277-92-2Formula C29H26ClFN4O4SMolar mass 581.07 g/molEC 878-720-7
GHS signal word: Warning. Pictograms: Harmful or irritant 118 suppliers listed Drug substance
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Lapatinib chemical structure, C29H26ClFN4O4S, CAS 231277-92-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
231277-92-2
Formula
C29H26ClFN4O4S
Molar mass
581.07 g/mol
Solubility
Yellow solid. Solubility at 25 eg C (mg/mL): 0.007 in water, 0.001 in 0.1 N HCl /Lapatin…
HS code
293499
Category
Oncology and immunology drugs

What is Lapatinib?

Plain description, key identifiers and synonyms

Lapatinib is a member of furans, an organochlorine compound, an organofluorine compound and a member of quinazolines. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is functionally related to a monofluorobenzene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
CAS number
231277-92-2 CAS number cross-checkedOther or deprecated CAS: 1092929-10-6, 1210608-87-9, 388082-78-8, 913989-15-8
EC number
878-720-7
Molecular formula
C29H26ClFN4O4S
UNII
0VUA21238F
MDL number
MFCD09264194
InChIKey
BCFGMOOMADDAQU-UHFFFAOYSA-N
InChI
InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
SMILES (canonical and isomeric)
CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Synonyms

  • GW 572016
  • GSK 572016
  • n-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine
  • N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine
  • N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
  • 4-Quinazolinamine, N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-
  • 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-
  • lapatinibum
  • N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-methanesulfonylethyl)amino)methyl)furan-2-yl)quinazolin-4-amine
  • GW 2016
  • N-(3-chloro-4-(((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine
  • Tykerb
  • Lapatinib free base
  • Lapatinib (free base)
  • Lapatanib
  • Lapatinib base
  • N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
  • 1xkk
  • N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine
  • 231277-92-2 (free base)
  • Lapatinib (INN)
  • FMM
  • N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
  • Kinome_3685
  • n-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
Show all 36 synonyms
  • Lapatinib (GW572016)
  • GW 282974X
  • C29H26ClFN4O4S
  • N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine
  • N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
  • Lapatinib?
  • Tykerb,
  • N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
  • N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
  • Lapatinib ditosylate?
  • Lapatinib (Standard)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
Yellow solid. Solubility at 25 eg C (mg/mL): 0.007 in water, 0.001 in 0.1 N HCl /Lapatinib ditoluenesulfonate monohydrate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
581.07 g/molcalc.
Exact mass
580.1347 Dacalc.
LogP (octanol/water)
6.14calc.
Topological polar surface area
106.4 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
11calc.
Heavy atoms
40calc.
Rings
5calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.17calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(COc2ccc(Nc3ncnc4ccc(-c5ccco5)cc34)cc2)cc1

c1ccc(COc2ccc(Nc3ncnc4ccc(-c5ccco5)cc34)cc2)cc1

5 rings, 30 atoms.

39 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H319Causes serious eye irritation.
  • H362May cause harm to breast-fed children.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (12)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P337 + P317If eye irritation persists: Get medical help.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Lapatinib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 118 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

118 suppliers in 18 countries

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Lapatinib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Antineoplastic Agents, Protein Kinase Inhibitors.

Industries and functions

Pharmacological actions

  • Antineoplastic Agents
  • Tyrosine Kinase Inhibitors

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Lapatinib is a Kinase Inhibitor. The mechanism of action of lapatinib is as a Protein Kinase Inhibitor.

How it is made

The synthesis route for (lapatinib) ... involves a Suzuki coupling of 5-formyl-2-furanboronic acid with the iodo-substituted quinazoline derivative.

Preparation: M. C. Carter et al., World Intellectual Property Organization patent 9935146 (1999 to Glaxo), eidem, United States of America patent 6727256 (2004 to SmithKline Beecham).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lapatinib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Lapatinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lapatinib, based on the data on this page

What is Lapatinib?

Lapatinib is a member of furans, an organochlorine compound, an organofluorine compound and a member of quinazolines. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is functionally related to a monofluorobenzene.

What is the CAS number of Lapatinib?

The CAS registry number of Lapatinib is 231277-92-2. Other or deprecated CAS numbers: 1092929-10-6, 1210608-87-9, 388082-78-8.

What is the molecular formula and weight of Lapatinib?

The molecular formula of Lapatinib is C29H26ClFN4O4S and its molar mass is 581.07 g/mol.

What is Lapatinib used for?

Antineoplastic Agents, Protein Kinase Inhibitors.

Is Lapatinib hazardous?

Lapatinib carries the GHS signal word "Warning". Main hazards: causes serious eye irritation, may cause harm to breast-fed children, may cause long lasting harmful effects to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Lapatinib?

Lapatinib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Lapatinib?

CompoundList lists 118 suppliers of Lapatinib in China, United States, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Lapatinib in India?

7 suppliers in India list Lapatinib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Lapatinib?

Suppliers quote Lapatinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Lapatinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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