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Heterocyclic building blocks

Tykerb

Also known as Lapatinib tosylate, Lapatinib-d7 Ditosylate, Lapatinib (tosylate)

CAS 1187538-35-7Formula C36H34ClFN4O7S2Molar mass 753.27 g/mol
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Tykerb chemical structure, C36H34ClFN4O7S2, CAS 1187538-35-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1187538-35-7
Formula
C36H34ClFN4O7S2
Molar mass
753.27 g/mol
HS code
293499
Category
Heterocyclic building blocks

What is Tykerb?

Plain description, key identifiers and synonyms

Tykerb is a chemical substance with the molecular formula C36H34ClFN4O7S2 and a molar mass of 753.27 g/mol. Its CAS registry number is 1187538-35-7. The IUPAC name is N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine, 4-methylbenzenesulfonic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine, 4-methylbenzenesulfonic acid
CAS number
1187538-35-7Other or deprecated CAS: 388082-77-7
Molecular formula
C36H34ClFN4O7S2
InChIKey
OZDXXJABMOYNGY-UHFFFAOYSA-N
InChI
InChI=1S/C29H26ClFN4O4S.C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2-5H,1H3,(H,8,9,10)
SMILES (canonical and isomeric)
CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Synonyms

  • Lapatinib tosylate
  • Lapatinib-d7 Ditosylate
  • Lapatinib (tosylate)
  • N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine, 4-methylbenzenesulfonic acid
  • GW 282974X
  • N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine, 4-methylbenzenesulfonic acid
  • 4-methylbenzene-1-sulfonic acid, N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
753.27 g/molcalc.
Exact mass
752.1541 Dacalc.
LogP (octanol/water)
7.38calc.
Topological polar surface area
160.7 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
12calc.
Heavy atoms
51calc.
Rings
6calc.
Aromatic rings
6calc.
Fraction sp3 carbons
0.17calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(COc2ccc(Nc3ncnc4ccc(-c5ccco5)cc34)cc2)cc1

c1ccc(COc2ccc(Nc3ncnc4ccc(-c5ccco5)cc34)cc2)cc1

5 rings, 30 atoms.

39 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Tykerb suppliers

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  • EvitaChem
    China, BeijingUnclaimed profile
    TykerbGrade, purity and minimum order on request
    Price on request
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Where suppliers are based

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Tykerb price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tykerb is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Tykerb is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tykerb, based on the data on this page

What is Tykerb?

Tykerb is a chemical substance with the molecular formula C36H34ClFN4O7S2 and a molar mass of 753.27 g/mol. Its CAS registry number is 1187538-35-7. The IUPAC name is N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine, 4-methylbenzenesulfonic acid.

What is the CAS number of Tykerb?

The CAS registry number of Tykerb is 1187538-35-7. Other or deprecated CAS numbers: 388082-77-7.

What is the molecular formula and weight of Tykerb?

The molecular formula of Tykerb is C36H34ClFN4O7S2 and its molar mass is 753.27 g/mol.

What is Tykerb used for?

Known uses and roles of Tykerb include building blocks in research and laboratory.

Is Tykerb hazardous?

No GHS hazard classification for Tykerb is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Tykerb?

Tykerb is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tykerb?

CompoundList lists 1 supplier of Tykerb in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tykerb?

Suppliers quote Tykerb on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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