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Aliphatic and alicyclic building blocks

Laromustine

Also known as Cloretazine, Onrigin, Laromustin

CAS 173424-77-6Formula C6H14ClN3O5S2Molar mass 307.78 g/mol
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Laromustine chemical structure, C6H14ClN3O5S2, CAS 173424-77-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
173424-77-6
Formula
C6H14ClN3O5S2
Molar mass
307.78 g/mol
HS code
293590
Category
Aliphatic and alicyclic building blocks

What is Laromustine?

Plain description, key identifiers and synonyms

Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream, 90CE chloroethylates alkylates the O6 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits O6-alkyl-guanine transferase, an enzyme involved with DNA repair.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[2-chloroethyl(methylsulfonyl)amino]-3-methyl-1-methylsulfonylurea
CAS number
173424-77-6 CAS number cross-checked
Molecular formula
C6H14ClN3O5S2
UNII
14J2G0U3NQ
InChIKey
PVCULFYROUOVGJ-UHFFFAOYSA-N
InChI
InChI=1S/C6H14ClN3O5S2/c1-8-6(11)10(17(3,14)15)9(5-4-7)16(2,12)13/h4-5H2,1-3H3,(H,8,11)
SMILES (canonical and isomeric)
CNC(=O)N(N(CCCl)S(=O)(=O)C)S(=O)(=O)C

Synonyms

  • Cloretazine
  • Onrigin
  • Laromustin
  • laromustina
  • laromustinum
  • 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine
  • 3-(N-(2-chloroethyl)methanesulfonamido)-3-methanesulfonyl-1-methylurea
  • VNP 40101M
  • 1-[2-chloroethyl(methylsulfonyl)amino]-3-methyl-1-methylsulfonylurea
  • 2-(2-chloroethyl)-N-methyl-1,2-bis(methylsulfonyl)hydrazinecarboxamide
  • Laromustine (USAN)
  • 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-((2-methylamino)carbonyl)hydrazine
  • Methanesulfonic acid, 1-(2-chloroethyl)-2-((methylamino)carbonyl)-2-(methylsulfonyl)hydrazide
  • 2'-(2-Chloroethyl)-N-methyl-1',2'-bis(methylsulfonyl)carbamohydrazide
  • 2-(2-Chloroethyl)-1,2-di(methanesulfonyl)-N-methylhydrazine-1-carboxamide
  • 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-((methylamino)carbonyl)hydrazine
  • 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino) carbonyl]hydrazine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
307.78 g/molcalc.
Exact mass
307.0063 Dacalc.
LogP (octanol/water)
-1calc.
Topological polar surface area
103.9 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
17calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.83calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Laromustine suppliers

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Laromustine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Laromustine is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Laromustine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Laromustine, based on the data on this page

What is Laromustine?

Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream, 90CE chloroethylates alkylates the O6 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA syn…

What is the CAS number of Laromustine?

The CAS registry number of Laromustine is 173424-77-6.

What is the molecular formula and weight of Laromustine?

The molecular formula of Laromustine is C6H14ClN3O5S2 and its molar mass is 307.78 g/mol.

What is Laromustine used for?

Known uses and roles of Laromustine include blowing agents in plastics and polymers, building blocks in research and laboratory, antineoplastic agent and pharmaceutical.

Is Laromustine hazardous?

No GHS hazard classification for Laromustine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Laromustine?

Laromustine is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Laromustine?

Post a free request on CompoundList and suppliers of Laromustine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Laromustine?

Suppliers quote Laromustine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Laromustine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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