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Heterocyclic building blocks

Lisofylline

Also known as (R)-Lisofylline, ProTec, Lisophylline

CAS 100324-81-0Formula C13H20N4O3Molar mass 280.33 g/mol
1 supplier listed
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Lisofylline chemical structure, C13H20N4O3, CAS 100324-81-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
100324-81-0
Formula
C13H20N4O3
Molar mass
280.33 g/mol
HS code
293359
Category
Heterocyclic building blocks

What is Lisofylline?

Plain description, key identifiers and synonyms

(R)-lisofylline is a 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione that has (R)-configuration. A synthetic small molecule which was under development for the treatment of type 1 diabetes mellitus. It has a role as an immunomodulator and an anti-inflammatory agent. It is an enantiomer of a (S)-lisofylline.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione
CAS number
100324-81-0 CAS number cross-checked
Molecular formula
C13H20N4O3
UNII
L1F2Q2X956
MDL number
MFCD00867573
InChIKey
NSMXQKNUPPXBRG-SECBINFHSA-N
InChI
InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/t9-/m1/s1
Canonical SMILES
CC(O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O
Isomeric SMILES
C[C@H](CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C)O

Synonyms

  • (R)-Lisofylline
  • ProTec
  • Lisophylline
  • lisofilina
  • CT 1501R
  • 1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione
  • Lisofylline, (r)-
  • lisofyllinum
  • (R)-Lisophylline
  • 1-[(R)-5-hydroxyhexyl]theobromine
  • 1-((R)-5-Hydroxyhexyl)theobromine
  • 1-(5R-Hydroxyhexyl)-3,7-dimethylxanthine
  • 1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • 1-((5R)-5-hydroxyhexyl)-3,7-dimethylpurine-2,6-dione
  • Lisofenicol
  • 1-((5R)-5-hydroxyhexyl)-3,7-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • 3,7-Dimethyl-1-(5-hydroxyhexyl)xanthine
  • 1-(5'-Hydroxyhexyl)-3,7-dimethylxanthine
  • 1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-
  • (R)-1-(5-Hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione
  • 3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione
  • 1H-Purine-2,6-dione, 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-
  • 1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-purine-2,6-dione
  • 1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • (-)-lisofylline
Show all 33 synonyms
  • ProTec (TN)
  • Lisofylline (USAN/INN)
  • (R)-LSF
  • 1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-, (R)-
  • LSF
  • 1-(5-R-hydroxyhexyl)-3,7-dimethylxanthine
  • R-1-(5-Hydroxyhexyl)-3,7-dimethylxanthine
  • 1-(5'-R-Hydroxyhexyl)-3,7-dimethylxanthine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
280.33 g/molcalc.
Exact mass
280.1535 Dacalc.
LogP (octanol/water)
-0.02calc.
Topological polar surface area
82.05 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.62calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]c(=O)c2[nH]cnc2[nH]1

O=c1[nH]c(=O)c2[nH]cnc2[nH]1

2 rings, 11 atoms, the Xanthine ring system.

1,880 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Lisofylline suppliers

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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

1 supplier in 1 country

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Lisofylline price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Adjuvants, Immunologic
  • Anti-Inflammatory Agents, Non-Steroidal
  • Immunosuppressive Agents
  • Radiation-Sensitizing Agents

Roles

  • anti-inflammatory agent
  • hypoglycemic agent
  • immunomodulator
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lisofylline is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Lisofylline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lisofylline, based on the data on this page

What is Lisofylline?

(R)-lisofylline is a 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione that has (R)-configuration. A synthetic small molecule which was under development for the treatment of type 1 diabetes mellitus. It has a role as an immunomodulator and an anti-inflammatory agent.

What is the CAS number of Lisofylline?

The CAS registry number of Lisofylline is 100324-81-0.

What is the molecular formula and weight of Lisofylline?

The molecular formula of Lisofylline is C13H20N4O3 and its molar mass is 280.33 g/mol.

What is Lisofylline used for?

Known uses and roles of Lisofylline include building blocks in research and laboratory, screening compounds in research and laboratory, anti-inflammatory agent, hypoglycemic agent, immunomodulator and 5 more.

Is Lisofylline hazardous?

No GHS hazard classification for Lisofylline is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Lisofylline?

Lisofylline is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Lisofylline?

CompoundList lists 1 supplier of Lisofylline in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Lisofylline?

Suppliers quote Lisofylline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Lisofylline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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